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Displaying results 161 - 170 of 134502 in total
  1. Pathway

    Hydrochlorothiazide Action Pathway

    smpdb.ca/view/SMP0000100
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … Solute carrier family 12 member 3 is also used for sodium reabsorption that count for 5% of total amount.

    Drugs: Cysteine · Hydrochlorothiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT
  2. Pathway

    Indapamide Action Pathway

    smpdb.ca/view/SMP0000110
    Drug action

    Sodium-chloride symporter (also known as solute carrier family 12 member 3) can translocate chloride and sodium from lumen to epithelial cell. … Indapamide (also named as Noranat or Veroxil) is a thiazide-like diuretic drug that can be used to treat hypertension and decompensated heart failure.

    Drugs: Cysteine · Indapamide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT
  3. Pathway

    Amiloride Action Pathway

    smpdb.ca/view/SMP0000133
    Drug action

    Amiloride is a diuretic that inhibits the sodium channels in the late distal convoluted tubule and collecting tube of the nephron where 1-2% of sodium reabsorption occurs. … Therefore, amiloride's inhibition of sodium reabsorption fails to produce an electrochemical gradient and therefore, inhibits potassium excretion.

    Drugs: Cysteine · Amiloride · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT
  4. Pathway

    Glucose Transporter Defect (SGLT2)

    smpdb.ca/view/SMP0000184
    Disease

    SGLT2 is a sodium/glucose co-transporter that exists almost exclusively in kidney tissue. … There are some drugs that inhibit SGLT2 and are used to decrease blood sugar in patients with type 2 diabetes mellitus.

    Drugs: Cysteine · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT
  5. Pathway

    Hartnup Disorder

    smpdb.ca/view/SMP0000189
    Disease

    Hartunup Disorder (HND, Hartnup Disease) is an autosomal recessive disease caused by a mutation in the SLC6A19 which codes for sodium-dependent neutral amino acid transporter B(0). … Symptoms include pellagra, psychosis, ataxia, and mental retardation. Treatment includes nicotinamide.

    Drugs: Cysteine · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT
  6. Pathway

    Lysinuric Protein Intolerance

    smpdb.ca/view/SMP0000197
    Disease

    A defect in this enzyme results in accumulation of ammmonia and reticulocytes in blood; glutamine in plasma, carnitine and ferritin in serum, and arginine, lysine and ornithine in urine. … Symptoms include bone marrow abnormality, growth retardation, hyperammoniemia, mental retardation, pancreatitis, and seizures.

    Drugs: Cysteine · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT
  7. Pathway

    Methyclothiazide Action Pathway

    smpdb.ca/view/SMP0000081
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … Solute carrier family 12 member 3 is also used for sodium reabsorption that count for 5% of total amount.

    Drugs: Cysteine · Methyclothiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT
  8. Pathway

    Hydroflumethiazide Action Pathway

    smpdb.ca/view/SMP0000108
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … Solute carrier family 12 member 3 is also used for sodium reabsorption that count for 5% of total amount.

    Drugs: Cysteine · Hydroflumethiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT
  9. Pathway

    Furosemide Action Pathway

    smpdb.ca/view/SMP0000115
    Drug action

    Furosemide can bind and inhibit sodium-potassium-chloride cotransporter (NKCC2/SLC22A1) to prevent the water reabsorption in nephron. … Inhibition of sodium-potassium-chloride cotransporter can prevent transportation of sodium from lumen to basolateral interstitium, which lead to more hypertonic in lumen and less hypertonic in basolateral

    Drugs: Cysteine · Furosemide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT
  10. Pathway

    Trichlormethiazide Action Pathway

    smpdb.ca/view/SMP0000121
    Drug action

    Trichlormethiazide also acts to inhibit sodium uptake and increase potassium excretion which also serves to increase fluid loss. … Trichloromethiazide acts by inhibiting chloride and potentially sodium reabsorption in the ascending loop of Henle, specifically at solute carrier family 12 member 3.

    Drugs: Cysteine · Trichlormethiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT