Search

Displaying results 161 - 170 of 597 in total
  1. Pathway

    Nimodipine Action Pathway

    smpdb.ca/view/SMP0000380
    Drug action

    This may be due to its high lipophilicity and ability to penetrate the blood brain barrier. … Without calcium ions in muscle cell, calmodulin couldn't form the calcium-bound calmodulin, which is required for binding and activating MLCK.

    Drugs: ATP · Nimodipine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  2. Pathway

    Nisoldipine Action Pathway

    smpdb.ca/view/SMP0000381
    Drug action

    Without calcium ions in muscle cell, calmodulin couldn't form the calcium-bound calmodulin, which is required for binding and activating MLCK. … Nisoldipine (also known as Sular or Nisocor) is a dihydropyridine calcium channel blocker that may be used for treatment of hypertension, chronic stable angina and Prinzmetal's variant angina.

    Drugs: ATP · Nisoldipine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  3. Pathway

    Carteolol Action Pathway

    smpdb.ca/view/SMP0000658
    Drug action

    Adrenaline (also known as epinephrine) can activate β1 adrenergic receptor so that the heart rate and output will be increased. … Carteolol (also known as Cartrol or Ocupress) is a selective β1 adrenergic receptor antagonist (beta blocker), which can be used for treatment of high blood pressure (hypertension) and irregular heartbeats

    Drugs: ATP · Carteolol · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  4. Pathway

    Dobutamine Action Pathway

    smpdb.ca/view/SMP0000662
    Drug action

    Dobutamine is a type of medication that can be used for treating heart failure and cardiogenic shock. … Dobutamine can bind to beta-1 adrenergic receptor on the heart cell which lead to mild chronotropic, arrhythmogenic, hypertensive and vasodilative effects.

    Drugs: ATP · Dobutamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  5. Pathway

    Levobunolol Action Pathway

    smpdb.ca/view/SMP0000666
    Drug action

    decreased blood pressure, heart rate and cardiac output. … Levobunolol bind to beta1-adrenergic and beta2-adrenergic receptors in heart and vascular smooth muscle to block the binding of other adrenergic neurotransmitters such as norepinephrine, which lead to

    Drugs: ATP · Levobunolol · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  6. Pathway

    Metipranolol Action Pathway

    smpdb.ca/view/SMP0000667
    Drug action

    Metipranolol binds to beta1-adrenergic and beta2-adrenergic receptors in heart and vascular smooth muscle. … Metipranolol demonstrates low intrinsic sympathomimetic activity, and weak local anesthetic (membrane-stabilizing) and myocardial depressant activity.

    Drugs: ATP · Metipranolol · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  7. Pathway

    Practolol Action Pathway

    smpdb.ca/view/SMP0000669
    Drug action

    , heart rate and cardiac output. … In juxtaglomerular apparatus, practolol can prevent the production of aldosterone and angiotensin II by inhibiting renin production, which lead to prevention of water retention and vasoconstriction.

    Drugs: ATP · Practolol · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  8. Pathway

    Atenolol Action Pathway

    smpdb.ca/view/SMP0000298
    Drug action

    Binding of atenolol inhibits the G protein signalling cascade and reduces heart rate, blood pressure, cardiac output and reflex orthostatic hypotension. … Atenolol is a selective beta-1-adrenoceptor antagonist targeting the heart and vascular smooth muscle to inhibit sympathetic activity.

    Drugs: ATP · Atenolol · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  9. Pathway

    Bisoprolol Action Pathway

    smpdb.ca/view/SMP0000300
    Drug action

    Blocking of beta1-adrenergic receptors in heart and vascular smooth muscle can lead to reduced heart rate, cardiac output, and decreased blood pressure. … Bisoprolol (also known as Zebeta) is a selective beta blocker that can block beta1-adrenergic receptors and beta2-adrenergic receptors.

    Drugs: ATP · Bisoprolol · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  10. Pathway

    Metoprolol Action Pathway

    smpdb.ca/view/SMP0000302
    Drug action

    , heart rate and cardiac output. … Metoprolol bind to beta1-adrenergic receptors in heart and vascular smooth muscle to block the binding of other adrenergic neurotransmitters such as norepinephrine, which lead to decreased blood pressure

    Drugs: ATP · Metoprolol · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1