Search
Apremilast
go.drugbank.com/drugs/DB05676ApprovedInvestigational[L7501] In July 2019, apremilast was granted a new FDA approval for the treatment of oral ulcers associated with Behcet's disease, an autoimmune condition that causes recurrent skin, blood vessel, and … Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases.
Mixtures: Mar-apremilast, Mar-apremilastCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesMidazolam
go.drugbank.com/drugs/DB00683ApprovedIllicitInvestigationalintramuscular (IM), and intravenous (IV) routes and has been used in various biomedical applications, including dentistry, cardiac surgery, and endoscopic procedures as pre-anesthetic medication, and as an … [L45098] In May 2019, the nasal spray of midazolam was approved for the acute treatment of distinctive intermittent, stereotypic seizure episodes in patients 12 years of age and older.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: Epistatus 5 mg Lösung zur Anwendung in der Mundhöhle, Epistatus 10 mg Lösung zur Anwendung in der MundhöhlePirfenidone
go.drugbank.com/drugs/DB04951ApprovedInvestigational[A251370] It is an antifibrotic agent with anti-inflammatory and antioxidant properties [A251370] that is used to treat idiopathic pulmonary fibrosis (IPF),[L26801] which is a chronic, progressive form … Pirfenidone is a synthetic pyridone drug.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: Mar-pirfenidone, PIRFENIDONE DR. REDDY?SSemzuvolimab
go.drugbank.com/drugs/DB18920InvestigationalSemzuvolimab is under investigation in clinical trial NCT03149211 (To Investigate the Efficacy and Safety of UB-421 Monotherapy in HIV-1 Infected Adults).
Synonyms: DB4C7 mAb, Mab db4c7Galantamine
go.drugbank.com/drugs/DB00674ApprovedInvestigationalIt also acts as an allosteric modulator of the nicotinic receptor, giving its dual mechanism of action clinical significance. … Under this hypothesized mechanism of action, the therapeutic effects of galantamine may decrease as the disease progression advances and fewer cholinergic neurons remain functionally intact.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: Mar-galantamine ER, REMINYL ®ER CAPSULAS DE 8 MGOxtriphylline
go.drugbank.com/drugs/DB01303ApprovedIts main physiological reponse is to dilate the bronchioles. As such, oxytriphylline is indicated mainly for asthma, bronchospasm, and COPD (i.e. all the same indications as the other theophyllines). … Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingSynonyms: Teofilinato de colina, Theophyllinate de cholineIron
go.drugbank.com/drugs/DB01592ApprovedInvestigationalDepletion of iron stores may result in iron-deficiency anemia. Iron is used to build up the blood in anemia. … A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems.
Mixtures: Re Kar C Plus, Supplement De FerSynonyms: ferTerbinafine
go.drugbank.com/drugs/DB00857ApprovedInvestigationalVet approved[A1279] Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell wall … Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues.
Mixtures: M-FURO MANT % 0.1 + % 1 KREM, 20G, Fluconazole 4% / Ibuprofen 2% / Itraconazole 1% / Terbinafine HCl 4%Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersSodium bicarbonate
go.drugbank.com/drugs/DB01390ApprovedInvestigationalSodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Mixtures: GASTROFULL ®MAX, GASTROFULL ®MAXProducts: SAL DE FRUTAS LUA®, BICARBONATO DE SODIO 1 MOLARChAd-triCoV/Mac
go.drugbank.com/drugs/DB24997InvestigationalChAd-triCoV/Mac is a biologic drug. ChAd-triCoV/Mac is under investigation in clinical trial NCT06381739 (A Trial of a Next Generation COVID-19 Vaccine Delivered by Inhaled Aerosol).
Synonyms: ChAd-triCoV/Mac