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Prasterone
go.drugbank.com/drugs/DB01708ApprovedInvestigationalNutraceuticalPrasterone, also known as dehydroepiandrosterone (DHEA) is a major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testost...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsStaurosporine
go.drugbank.com/drugs/DB02010ExperimentalAn indolocarbazole that is a potent protein kinase C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)
Categories: P-glycoprotein inhibitorsXanthine
go.drugbank.com/drugs/DB02134InvestigationalA purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xa...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesEnasidenib
go.drugbank.com/drugs/DB13874ApprovedInvestigationalEnasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with specific mutations in the isocitrate dehydrogenase 2 (IDH2) gene, which is a recurrent mutation...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesTestosterone cypionate
go.drugbank.com/drugs/DB13943ApprovedInvestigationalTestosterone cypionate is a synthetic derivative of testosterone in the form of an oil-soluble 17 (beta)-cyclopentylpropionate ester. Its benefit compared to other testosterone derivatives is the slow rate of release after injection and ...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesTestosterone enanthate
go.drugbank.com/drugs/DB13944ApprovedInvestigationalTestosterone enanthate is an esterified variant of testosterone that comes as an injectable compound with a slow-release rate. This slow release is achieved by the presence of the enanthate ester functional group attached to the testoste...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesEstradiol cypionate
go.drugbank.com/drugs/DB13954ApprovedVet approvedEstradiol Cypionate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSarracenia Purpurea
go.drugbank.com/drugs/DB13965ApprovedWithdrawnSarracenia purpurea, commonly known as the purple pitcher plant, northern pitcher plant, turtle socks, or side-saddle flower, is a perennial carnivorous plant in the family Sarraceniaceae. Sarracenia purpurea attract and trap insects wit...
Products: P-BlocHycanthone
go.drugbank.com/drugs/DB14061ExperimentalPotentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE. Hycanthone was approved by the FDA in 1975 but is no longer used.
Categories: P-glycoprotein inhibitorsCobalt chloride
go.drugbank.com/drugs/DB14206ApprovedCategories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme Inhibitors