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Paliperidone
go.drugbank.com/drugs/DB01267ApprovedInvestigationalPaliperidone was approved by the FDA for treatment of schizophrenia on December 20, 2006. … Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: INVEGA 3 MG RETARDTABLETTE, INVEGA 3 MG EXTENDED RELEASE TABLETSChorionic Gonadotropin (Human)
go.drugbank.com/drugs/DB09126ApprovedInvestigationalVet approvedEndogenously produced HCG interacts with the LHCG receptor of the ovary and promotes the maintenance of the corpus luteum during the beginning of pregnancy. … of human thyroid-stimulating hormone (TSH), while the beta sub units of these hormones differ in amino acid sequence.
Categories: Sex Hormones and Modulators of the Genital SystemSetmelanotide
go.drugbank.com/drugs/DB11700ApprovedInvestigational[A224449] Patients taking setmelanotide experienced an average weight loss of 0.6 kg/week. … [A224449] Imcivree was granted EMA orphan designation on November 19, 2018 [L24559] and FDA approval on November 25, 2020.[L24429] On May 4, 2023, it was approved by Health Canada.[L46327]
Toripalimab
go.drugbank.com/drugs/DB15043ApprovedInvestigationalThe proliferation of some cancers can be attributed, at least in part, to the suppression of host tumor surveillance. … of T-cell proliferation and cytokine production, and thus its overexpression can inhibit T-cell-mediated immune surveillance of tumors.
Pemigatinib
go.drugbank.com/drugs/DB15102ApprovedInvestigationalWith increasing research on the pathogenesis of cholangiocarcinoma and potential therapeutic targets for anticancer drug treatment, recent studies show that up to 45% of patients with intrahepatic cholangiocarcinoma … This malignancy accounts for 15% to 20% of primary hepatobiliary malignancies, which account for 13% of overall cancer-related global mortality.
Abiraterone
go.drugbank.com/drugs/DB05812ApprovedInvestigational[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April,[A260880] July,[L47745] and September 2011,[A260880] respectively. … Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis
Categories: Metabolic Side Effects of Drugs and SubstancesSynonyms: 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol, (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-olHolcus lanatus pollen
go.drugbank.com/drugs/DB10395ApprovedHolcus lanatus pollen is the pollen of the Holcus lanatus plant. Holcus lanatus pollen is mainly used in allergenic testing.
Mixtures: Mixture of Standardized and Non-Standardized Coastal Grasses, Mixture of Twenty-Two Standardized and Non-Standardized GrassesArrhenatherum elatius pollen
go.drugbank.com/drugs/DB10879ApprovedArrhenatherum elatius pollen is the pollen of the Arrhenatherum elatius plant. Arrhenatherum elatius pollen is mainly used in allergenic testing.
Mixtures: Mixture of Standardized and Non-Standardized Coastal Grasses, Mixture of Twenty-Two Standardized and Non-Standardized GrassesTolbutamide
go.drugbank.com/drugs/DB01124ApprovedMedications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. … It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin
Categories: combinations of sulfonamidesProducts: TOLMIDE TABLET 500 mg, TOBUMIDE TABLET 500 mgFerrous asparto glycinate
go.drugbank.com/drugs/DB11169ApprovedIt is available as a dietary supplement used in the treatment of iron deficiency and iron deficiency anemia.
Mixtures: Paire OB Plus DHA, OB Complete DHA