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Entacapone
go.drugbank.com/drugs/DB00494ApprovedInvestigationalEntacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. … When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa concentrations are reached as compared to the administration
Mixtures: LEVOCAENT-NX 100/25/200, LEVOCAENT-NX 100/25/200Synonyms: (E)-alpha-Cyano-N,N-diethyl-3,4-dihydroxy-5-nitrocinnamamide, N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl) acrylamideMaprotiline
go.drugbank.com/drugs/DB00934ApprovedIt differs from TCAs in that it does not appear to block serotonin reuptake. … Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity.
Categories: Non-Selective Monoamine Reuptake Inhibitors, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeAlogliptin
go.drugbank.com/drugs/DB06203ApprovedInvestigationalIt undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25, 2013.
Butamben
go.drugbank.com/drugs/DB11148ApprovedWithdrawn[A27147] Its structure corresponds to the standard molecule of a hydrophilic and hydrophobic domain separated by an intermediate ester found in most of the local anesthetics. … Butamben is a local anesthetic in the form of n-butyl-p-aminobenzoate.
Tannic acid
go.drugbank.com/drugs/DB09372ApprovedInvestigationalTannic acid is found in the nutgalls formed by insects on twigs of certain oak trees (Quercus infectoria and other Quercus species). It is removed and used as medicine. … Tannic acid is also taken by mouth and applied directly for bleeding, chronic diarrhea, dysentery, bloody urine, painful joints, persistent coughs, and cancer.
Mixtures: NEO-EMOCICATROLElotuzumab
go.drugbank.com/drugs/DB06317ApprovedInvestigationalElotuzumab is produced in NS0 cells by recombinant DNA technology. Elotuzumab has a theoretical mass of 148.1 kDa for the intact antibody. Elotuzumab was approved on November 30, 2015 by the U.S. … Elotuzumab is marketed under the brand Empliciti™ by Bristol-Myers Squibb.
Fosdenopterin
go.drugbank.com/drugs/DB16628ApprovedBy improving the three-year survival rate from 55% to 84%,[L32288] and considering the lack of alternative therapies available, fosdenopterin appears poised to become a standard of therapy in the management … [A230088] Fosdenopterin was approved by the FDA on Februrary 26, 2021, for the reduction of mortality in patients with MoCD type A,[L32163] becoming the first and only therapy approved for the treatment
Azatadine
go.drugbank.com/drugs/DB00719ApprovedWithdrawnAntihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells.
Mixtures: CO-TYLENOLDaclizumab
go.drugbank.com/drugs/DB00111ApprovedInvestigationalWithdrawnRegardless of the withdrawal of Zenapax, Biogen and Abbvie's Zinbryta (daclizumab), as indicated for the treatment of adult patients with relapsing forms of multiple sclerosis, was approved for use by … and confirmed that this decision was not related to any safety concerns associated with the use of Zenapax (daclizumab) [L1744].
Iophendylate
go.drugbank.com/drugs/DB01187ApprovedIt next appeared on the world scene for high volume (12-15cc), routine use, in diagnosing disc herniations. A number of clinicians have published on the dangers of oil myelography. … Iophendylate, which was never shown to be safe, was initially introduced for use in small amounts (1-2cc) for locating spinal tumors.
Categories: Non-Watersoluble X-Ray Contrast Media