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Hydroflumethiazide
go.drugbank.com/drugs/DB00774ApprovedWithdrawnA thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822)
Categories: combinations of sulfonamidesVericiguat
go.drugbank.com/drugs/DB15456ApprovedInvestigationaldeficiencies in its production (primarily due to insufficient NO bioavailability) in the pathogenesis of various cardiovascular diseases. … [A227458,A227488] Cyclic GMP acts as a second messenger, activating a number of downstream signaling cascades that elicit a broad variety of effects, and these diverse cellular effects have implicated
Urea C-14
go.drugbank.com/drugs/DB09513ApprovedInvestigationalIt is currently used for the Urea Breath Test (UBT) and is available as a rapid diagnostic test (marketed as PyTest) for the detection of Helicobacter pylori infections. … As the urease enzyme is not present in mammalian cells, the presence of urease (and the products of urea cleavage) in the stomach is evidence that H. pylori bacteria are present.
Amlexanox
go.drugbank.com/drugs/DB01025ApprovedWithdrawnAmlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. … Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of the general population.
International brands: OraDisc ANorgestimate
go.drugbank.com/drugs/DB00957ApprovedInvestigational[A191068] It was developed by Ortho Pharmaceutical Corporation as part of an effort to develop new hormonal contraceptives with reduced adverse effects. … [L11845,L11848] Norgestimate was granted FDA approval on 29 December 1989.[L11842]
Categories: Sex Hormones and Modulators of the Genital SystemSynonyms: d-13β-Ethyl-17α-ethynyl-17β-acetoxygon-4-en-3-one oximeSofosbuvir
go.drugbank.com/drugs/DB08934ApprovedInvestigationalthe intent to cure, or achieve a sustained virologic response (SVR), after 12 weeks of daily therapy. … This is an important advantage relative to HCV drugs that target other viral enzymes such as the protease, for which rapid development of resistance has proven to be an important cause of therapeutic failure
Categories: Antivirals for treatment of HCV infectionsXenon Xe-129
go.drugbank.com/drugs/DB17386ApprovedInvestigationalLung MRIs are challenging due to the low proton density of this tissue, as well as the presence of artifacts due to respiration and cardiovascular pulsation movement and air–tissue interfaces. … They undergo a process that increases nuclear polarization up to five orders of magnitude, leading to a higher MRI signal.
Synonyms: Xenon, isotope of mass 129m(8.88 d), Xenon, isotope of mass 129Categories: Diagnostic Uses of ChemicalsLasmiditan
go.drugbank.com/drugs/DB11732ApprovedInvestigational[sumatriptan]) have seen preferential use in the acute treatment of migraines due to their relatively favourable efficacy and safety. … [A187322,A187319] Selectivity for 5-HT<sub>1F</sub>, a lack of vasoconstrictive activity, and the ability to terminate migraines through neuronal inhibition has resulted in the creation of a new class
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeTaurine
go.drugbank.com/drugs/DB01956ApprovedInvestigationalNutraceutical[A31396] This conditional amino acid can be either be manufactured by the body or obtained in the diet mainly by the consumption of fish and meat. … Taurine, whose chemical name is 2-aminoethanesulfonic acid, is one of the most abundant amino acids in several organs. It plays important role in essential biological processes.
Mixtures: AA-Ven, Protect Cardio AFEmapalumab
go.drugbank.com/drugs/DB14724ApprovedInvestigational[L4840] As well, emapalumab was given the status of PRIME by the EMA.[L4845] … Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma.