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Ravulizumab
go.drugbank.com/drugs/DB11580ApprovedInvestigationalRavulizumab is a potent and selective complement 5 (C5) inhibitor. It is a humanized monoclonal IgG2/4 kappa antibody produced in Chinese hamster ovary (CHO) cells. … [A244465] It was later approved by the European Commission on July 2, 2019, for the same indications.[L39710] Ravulizumab is also used to treat myasthenia gravis.
Products: Ultomiris 100mg/mL Concentrate For Solution For InfusionGivinostat
go.drugbank.com/drugs/DB12645ApprovedInvestigationalIt has been investigated as a treatment for a variety of inflammatory diseases, like Crohn's disease and juvenile idiopathic arthritis, cancers like leukemia and lymphoma, as well as several muscular dystrophies … Givinostat is a small molecule histone deacetylase (HDAC) inhibitor.
Pramipexole
go.drugbank.com/drugs/DB00413ApprovedInvestigationalIn addition to the above FDA approval for Parkinson's Disease, pramipexole was also approved by the FDA in 2006 for the treatment of Restless Legs Syndrome (RLS) [A176873]. … Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD).
Products: PRAMIPEXOL AL 2.1MG RET, PRAMIPEXOLO SANDOZ A/SEflornithine
go.drugbank.com/drugs/DB06243ApprovedInvestigationalWithdrawnEflornithine is an irreversible ornithine decarboxylase inhibitor originally developed as a treatment for human African trypanosomiasis. … [A4112, A262834] Additionally, ornithine decarboxylase is activated by c-myc or interacts with ras, both very well-known oncogenes, thus increasing the interest in targeting ornithine carboxylase as a
Creatine
go.drugbank.com/drugs/DB00148ApprovedInvestigationalNutraceuticalAn amino acid derivative that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as creatinine in the urine.
Aztreonam
go.drugbank.com/drugs/DB00355ApprovedInvestigationalIt may cause a superinfection with gram-positive organisms. … A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseProducts: AZACTAM FOR INJECTION 1 g/vial, AZBIOS® 1G POLVO PARA RECONSTITUIR A SOLUCION INYECTABLEImlifidase
go.drugbank.com/drugs/DB15258ApprovedInvestigational[A225836] High levels of anti-HLA antibodies also contribute to poor graft survival. … Chronic kidney disease (CKD) is a progressive and irreversible disease that represents a significant burden for both the individual and healthcare system at large.
Pemoline
go.drugbank.com/drugs/DB01230ApprovedIllicitWithdrawnIn 2005, the Food and Drug Administration (FDA) withdrew approval for pemoline. In March 2005, Abbott Laboratories (Cylert marketer) had discontinued the production of Cylert arguing economic reasons.
Categories: Psychostimulants, Agents Used for ADHD and NootropicsEstradiol benzoate
go.drugbank.com/drugs/DB13953ApprovedVet approvedWithdrawnEstradiol Benzoate is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously within the human body. … As a pro-drug of estradiol, estradiol benzoate therefore has the same downstream effects within the body through binding to the Estrogen Receptor (ER) including ERα and ERβ subtypes, which are located
Categories: Hormonal Contraceptives for Systemic UseLenvatinib
go.drugbank.com/drugs/DB09078ApprovedInvestigationalHowever, for patients with RAI-refractory thyroid cancer, treatment options are limited and the prognosis is poor, leading to a push for the development of more targeted therapies such as lenvatinib. … In particular, VEGF has been identified as a crucial regulator of both physiologic and pathologic angiogenesis and increased expression of VEGF is associated with a poor prognosis in many types of cancers