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Displaying results 1731 - 1740 of 1777 in total
  1. Target

    ATPase GET3

    go.drugbank.com/bio_entities/BE0000750
    TargetHumans

    This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion.

    Synonyms: Transmembrane domain recognition complex 40 kDa ATPase subunit
  2. Drug

    Carbon monoxide

    go.drugbank.com/drugs/DB11588
    ApprovedInvestigational

    A test of the diffusing capacity of the lungs for carbon monoxide (DLCO), is one of the most clinically valuable tests of lung function testing.

  3. Drug

    Rituximab

    go.drugbank.com/drugs/DB00073
    ApprovedInvestigational

    Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine ...

  4. Target

    Cyclin-dependent kinase 7

    go.drugbank.com/bio_entities/BE0001913
    TargetHumans

    Catalytic subunit of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalyzing the activating threonine phosphorylation of CDKs (PubMed:41100585). … Initiates transcription by RNA polymerase II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting dissociation from

    Synonyms: TFIIH basal transcription factor complex kinase subunit
  5. Drug

    Durvalumab

    go.drugbank.com/drugs/DB11714
    ApprovedInvestigational

    Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture, durval...

  6. Target

    Heat shock 70 kDa protein 13

    go.drugbank.com/bio_entities/BE0008957
    TargetHumans

    Has peptide-independent ATPase activity

    Synonyms: Microsomal stress-70 protein ATPase core
  7. Target

    Runt-related transcription factor 1

    go.drugbank.com/bio_entities/BE0010423
    TargetHumans

    Forms the heterodimeric complex core-binding factor (CBF) with CBFB. … RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their

    Synonyms: Core-binding factor subunit alpha-2, SL3/AKV core-binding factor alpha B subunit
  8. Target

    Protein S100-A8

    go.drugbank.com/bio_entities/BE0008955
    TargetHumans

    Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme … The iNOS-S100A8/A9 transnitrosylase complex directs selective inflammatory stimulus-dependent S-nitrosylation of GAPDH and probably multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL

    Synonyms: Leukocyte L1 complex light chain
  9. Drug

    Varicella zoster vaccine (recombinant)

    go.drugbank.com/drugs/DB13924
    ApprovedInvestigational

    One of the most common complications associated with shingles is the development of Post-Herpetic Neuralgia (PHN), a persistant severe nerve pain that develops as a result of chronic pain from shingles

  10. Drug

    Queuine

    go.drugbank.com/drugs/DB14732
    ExperimentalNutraceutical

    Queuine is a derivative of 7-Deazaguanine. Bacteria possess the exclusive ability to synthesize queuine, which is then salvaged and passed on to plants and animals. Quantities of queuine have been found in tomatoes, wheat, coconut water,...