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Alteplase
go.drugbank.com/drugs/DB00009ApprovedInvestigationalAlteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent.[L43125] It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. … [A252330,L43125] Alteplase is a purified glycoprotein of 527 amino acids expressed in Chinese hamster ovary (CHO) cells.
Synonyms: t-PA, rt-PAMixtures: Activase RT-PA, Lysatec RT - PaTerlipressin
go.drugbank.com/drugs/DB02638ApprovedInvestigationalTerlipressin is a synthetic analogue of vasopressin, which is an endogenous neurohormone that acts as a vasoconstrictor.[A2601] It is a prodrug of [lypressin], or lysine vasopressin. … [L43217] As a potent vasopressor, terlipressin has been investigated in various shock states and conditions with diminished vasomotor tone.
Products: HAEMOPRESSIN® 1 MG, GLYPRESSIN ® 1 MGXylitol
go.drugbank.com/drugs/DB11195ApprovedInvestigationalThe recommended dose of xylitol for dental caries prevention is 6–10 g/day, and most adults can tolerate 40 g/day without adverse events [A22081]. … It is widely used as a sugar substitute and in "sugar-free" food products.
Synonyms: D-XylitolMixtures: Fluor-a-day, Fluor-a-dayFamciclovir
go.drugbank.com/drugs/DB00426ApprovedInvestigationalFamciclovir is a prodrug of penciclovir with higher oral bioavailability. … Famciclovir, marketed as Famvir by Novartis, is a guanine analogue used to treat herpes virus infections. It is most commonly used to treat herpes zoster (shingles).
Synonyms: 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine, 2-(2-(2-amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetateCategories: Heterocyclic Compounds, 2-RingTranylcypromine
go.drugbank.com/drugs/DB00752ApprovedInvestigationalA propylamine formed from the cyclization of the side chain of amphetamine. … Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine with the chiral centers both located on the cylopropane ring.
Synonyms: (1R*,2S*)-2-phenylcyclopropan-1-amine, (±)-trans-2-phenylcyclopropylamineCategories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Cytochrome P-450 CYP1A2 InhibitorsProtionamide
go.drugbank.com/drugs/DB12667ApprovedInvestigationalWithdrawnProthionamide has been used in trials studying the treatment of MDR-TB and HIV Infections.
Categories: Heterocyclic Compounds, 1-RingProducts: TIONAMID 250 MG DRAJE, 500 ADET, TIONAMID 250 MG DRAJE, 50 ADETDexchlorpheniramine maleate
go.drugbank.com/drugs/DB09555ApprovedDexchlorpheniramine is the S-enantiomer of chlorpheniramine which is a 1st generation anti-histamine. … Dexchlorpheniramine has more pharmacological activity than the R and so is more potent than the racemic mixture.
Mixtures: HUFADEXTA-M, INTUNAL-FCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsRamucirumab
go.drugbank.com/drugs/DB05578ApprovedInvestigationalRamucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. … By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stimulated receptor phosphorylation and downstream ligand-induced proliferation,
Categories: Vascular Endothelial Growth Factor Receptor 2 AntagonistProducts: CYRAMZA 500 MG/50 ML İNFÜZYONLUK ÇÖZELTİ KONSANTRESİ İÇEREN FLAKON, 1 ADET, CYRAMZA 100MG/10 ML INFÜZYONLUK ÇÖZELTI KONSANTRESI IÇEREN FLAKON, 1 ADETFebuxostat
go.drugbank.com/drugs/DB04854ApprovedInvestigationalFebuxostat is a non-purine xanthine oxidase (XO) inhibitor. … [A39743] In early 2008, febuxostat was granted marketing authorization by the European Commission for the treatment of chronic hyperuricemia and gout.
Synonyms: 2-(3-cyano-4-isobutoxyphenyl)-4-methyl- 1,3-thiazole-5-carboxylic acidCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesCinnarizine
go.drugbank.com/drugs/DB00568ApprovedInvestigationalCinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockage), which happen mostly in brain. … Cinnarizine is a specific calcium channel blocker that primarily works on the central vestibular system to interfere with the signal transmission between vestibular apparatus of the inner ear and the vomiting
Synonyms: 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine, 1-Benzhydryl-4-cinnamylpiperazinMixtures: Arlevert 20 mg/40 mg Tabletten