Protionamide

DB12667ApprovedInvestigationalWithdrawnSmall molecule

Protionamide is an antitubercular thioamide-derivative used in the treatment of multi-drug resistant (MDR) tuberculosis and leprosy. Prothionamide has been used in trials studying the treatment of MDR-TB and HIV Infections.

Formula / weight: C₉H₁₂N₂S · 180.27 g/mol (avg)
Also known as: Prothionamide
Code names: RP-9778 · TH-1321

Resolves to

Compound

UNII76YOO33643CAS14222-60-7ChEMBLCHEMBL1378024ChEBI32066PubChem666418KEGGD01195

Clinical / RWD

RxNorm8871ATCJ04AD01ATCJ04AM10ATCJ04AM11

Structure

InChIKeyVRDIULHPQTYCLN-UHFFFAOYSA-NSMILESCCCC1=CC(=CC=N1)C(N)=S

Targets

P9WGR1inhA

What you can answer from here — as of March 06, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

58Drug interactionsStructured to mechanism, not free text

9Clinical trialsPhase, status and sponsor resolved per trial

2Structured indicationsCondition, population, route and combination as fields, not prose

9ContraindicationsEach with its own population and attribute set

3Marketed productsAcross 1 country and 2 labellers

3ATC codesIncluding every combination product, plus 8 drug categories

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with Protionamide, and which of those have an active Phase 3 trial?

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