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Phenformin
go.drugbank.com/drugs/DB00914ApprovedWithdrawnAlthough it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. … A biguanide hypoglycemic agent with actions and uses similar to those of metformin.
Categories: Drugs Used in DiabetesPolycarbophil
go.drugbank.com/drugs/DB09311ApprovedWithdrawnIt is insoluble in water, dilute acids, and dilute alkali. … Polycarbophil calcium is a synthetic polymer manufactured from the cross-linking of polyacrylic acid with divinyl glycol and a calcium counter-ion.
Categories: Compounds used in a research, industrial, or household settingIndigotindisulfonic acid
go.drugbank.com/drugs/DB11577ApprovedInvestigationalIndigotindisulfonic acid is a blue-colored dye with a variety of uses. … [A32490,A32491,A32492] In 2022, the FDA approved the intravenous use of indigotindisulfonate sodium to aid in visualizing ureter integrity in cystoscopic assessments.[L42600]
Categories: Compounds used in a research, industrial, or household settingGlecaprevir
go.drugbank.com/drugs/DB13879ApprovedInvestigationalIn cell cultures, the emergence of amino acid substitutions at NS3 resistance-associated positions A156 or D/Q168 in HCV genotype 1a, 2a or 3a replicons led to reduced susceptibility to glecaprevir [FDA … In combination with [DB13878], glecaprevir is a useful therapy for patients who experienced therapeutic failure from other NS3/4A protease inhibitors.
Categories: NS3/4A Protease Inhibitors, HCV NS3/4A Protease InhibitorsPegulicianine
go.drugbank.com/drugs/DB18731ApprovedInvestigational[L50537] The _in vivo_ enzymatic cleavage of pegulicianine results in two optically active fragments that emit a fluorescent signal that can be detected using a fluorescence imaging device. … Pegulicianine is an optical imaging agent indicated for fluorescence imaging in patients with breast cancer.
Categories: Compounds used in a research, industrial, or household settingBifenthrin
go.drugbank.com/drugs/DB15056ExperimentalBifenthrin is under investigation in clinical trial NCT01560247 (Percutaneous Recanalization in Ischemic Stroke Management in Europe Observational Registry).
Lithium carbonate
go.drugbank.com/drugs/DB14509ApprovedInvestigationalLithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. … Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843].
Mixtures: BIOGROW MINCategories: Drugs that are Mainly Renally Excreted with a Narrow Therapeutic IndexCalcium Phosphate
go.drugbank.com/drugs/DB11348ApprovedInvestigationalCalcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] [L851].
Mixtures: PNV Prenatal Vitamin Plus Vitamin ACategories: Compounds used in a research, industrial, or household settingLevacetylmethadol
go.drugbank.com/drugs/DB01227ApprovedWithdrawnLevacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. … Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well.[L44052,T862]
Categories: Drugs Used in Opioid Dependence, Drugs Used in Addictive DisordersAntithrombin Alfa
go.drugbank.com/drugs/DB11166ApprovedAntithrombin Alfa is a recombinant antithrombin , an anticoagulant, that is used for the prevention of thromboembolic events in patients that have hereditary deficiency of antithrombin in high risk situations
Categories: Factor Xa Inhibitors