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Polycarbophil

It is insoluble in water, dilute acids, and dilute alkali. … Polycarbophil calcium is a synthetic polymer manufactured from the cross-linking of polyacrylic acid with divinyl glycol and a calcium counter-ion.

Phenformin

Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. … A biguanide hypoglycemic agent with actions and uses similar to those of metformin.

Pegulicianine

[L50537] The _in vivo_ enzymatic cleavage of pegulicianine results in two optically active fragments that emit a fluorescent signal that can be detected using a fluorescence imaging device. … Pegulicianine is an optical imaging agent indicated for fluorescence imaging in patients with breast cancer.

Levoleucovorin

This results in a deficiency of coenzymes and a resultant buildup of toxic substances that are responsible for numerous adverse side effects of methotrexate therapy. … As methotrexate functions as a DHFR inhibitor to prevent DNA synthesis in rapidly dividing cells, it also prevents the formation of DHF and THF.

Lithium carbonate

Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. … Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843].

Indigotindisulfonic acid

Indigotindisulfonic acid is a blue-colored dye with a variety of uses. … [A32490,A32491,A32492] In 2022, the FDA approved the intravenous use of indigotindisulfonate sodium to aid in visualizing ureter integrity in cystoscopic assessments.[L42600]

Dostarlimab

A prospective phase II study in patients with mismatch repair-deficient locally advanced rectal cancer resulted in all twelve patients exhibiting a complete clinical response.[A248905] … [L33340] This indication was granted full FDA approval on February 10, 2023.[L45161] Dostarlimab-gxly was granted second accelerated approval for the treatment of solid tumours in the same month.

Borneol

Polyethylene glycol 300

PEG 300 is found in eye drops as a lubricant to temporarily relieve redness, burning and irritation of the eyes. … It is a clear viscous liquid at room temperature with non-volatile, stable properties [A33116].

Levacetylmethadol

Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. … Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well.[L44052,T862]