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Odesivimab
go.drugbank.com/drugs/DB15900ApprovedInvestigational[A221825, A221830] A recent large-scale study elucidated that both neutralizing and Fc-mediated functions of antibodies were important for therapeutic benefit in animal models of EBOV infection. … (i.e. through Fc-mediated immune effector function) antibody effects to play a role in combatting EBOV infection.
Categories: Treatments for Ebola Virus DiseaseProthrombin
go.drugbank.com/drugs/DB11311ApprovedInvestigationalProthrombin Complex Concentrate (Human), is indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with
Mixtures: BERIPLEX P/N 500 POWDER FOR SOLUTION FOR INJECTION, OCTAPLEX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IUDesipramine
go.drugbank.com/drugs/DB01151ApprovedThey contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. … See toxicity section below for a complete listing of side effects.
Categories: Antidepressive Agents Indicated for Depression, Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic IndexSynonyms: N-(3-methylaminopropyl)iminobibenzylTrimethadione
go.drugbank.com/drugs/DB00347ApprovedWithdrawnAn anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
Talquetamab
go.drugbank.com/drugs/DB16678ApprovedInvestigational[L47765] Talquetamab binds to GPRC5D, a cell surface receptor expressed predominantly on multiple myeloma cells, and CD3 on T cells. … [A260890] The Committee for Medicinal Products for Human Use (CHMP) of the EMA recommended conditional marketing authorization for talquetamab for the treatment of relapsed or refractory multiple myeloma
Synonyms: SAPIENS GPRC5D (G PROTEIN-COUPLED RECEPTOR CLASS C GROUP 5 MEMBER D)), AND ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON, LEU-4)), HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODY; BISPECIFIC GAMMA4 HEAVY CHAIN HUMANIZED ANLomefloxacin
go.drugbank.com/drugs/DB00978ApprovedAdditionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. … Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs).
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseCobicistat
go.drugbank.com/drugs/DB09065ApprovedInvestigationalMore specifically, cobicistat is indicated to increase systemic exposure of atazanavir or darunavir (once daily dosing regimen) in combination with other antiretroviral agents in the treatment of HIV-1 … Increasing systemic exposure of anti-retrovirals (ARVs) without increasing dosage allows for better treatment outcomes and a decreased side effect profile.
Categories: Antivirals used in combination for the treatment of HIV infections, Antiinfectives for Systemic UseIsoprenaline
go.drugbank.com/drugs/DB01064ApprovedInvestigationalIsoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion … [A233724,A233729] The US patent from 1943 states that this compound had a wider therapeutic index and a stronger action than [adrenaline].
Categories: Compounds used in a research, industrial, or household setting, Adrenergics for Systemic UseSynonyms: N-Isopropylnoradrenaline, N-IsopropylnorepinephrineTirbanibulin
go.drugbank.com/drugs/DB06137ApprovedInvestigationalTirbanibulin (KX-O1 or KX2–391) is a dual inhibitor of Src Kinase and tubulin. … [A225726] On December 14, 2020, tirbanibulin was approved by the FDA for the topical treatment of actinic keratosis on the face or scalp. It is marketed under the brand name Klisyri.