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Lasmiditan
go.drugbank.com/drugs/DB11732ApprovedInvestigational[A187322,A187319] Selectivity for 5-HT<sub>1F</sub>, a lack of vasoconstrictive activity, and the ability to terminate migraines through neuronal inhibition has resulted in the creation of a new class … [L9338,L9356] It was also approved by the European Commission on August 17, 2022.[L43997] Traditionally, the triptan class of anti-migraine medications (e.g.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, MATE 1 InhibitorsProducts: 1 RayvowRaltegravir
go.drugbank.com/drugs/DB06817ApprovedInvestigationalRaltegravir is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. … Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive such approval.
Categories: Heterocyclic Compounds, 1-Ring, Antivirals used in combination for the treatment of HIV infectionsProducts: ISENTRESS® 600MG TABLETAS, ISENTRESS-G TABLET 400MGBordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated)
go.drugbank.com/drugs/DB10991ApprovedInvestigationalBordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) is a vaccine that is used in the prophylaxis of Pertussis (whooping cough), which is caused by a small Gram-negative coccobacillus … that infects the mucosal layers of the human respiratory tract.
Mixtures: INFANRIX (TM) - IPV, PENTAXİM 0,5 ML IM ENJEKSİYONLUK SÜSPANSİYON İÇİN TOZ İÇEREN FLAKON VE SÜSPANSİYON İÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 ADETZiprasidone
go.drugbank.com/drugs/DB00246ApprovedInvestigational[A180748] Although ziprasidone is classified as an atypical antipsychotic, it appears to have a lower incidence of metabolic adverse effects compared to other medications in the same class.[A190525] … generally thought to be as efficacious as first generation antipsychotics but differ in their adverse effect profiles.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesProducts: GEODON® CAPSULAS 80 MG, ICIN KURU TOZ ICEREN FLAKON 20MG/ML FLAKON, 1 ADETRivaroxaban
go.drugbank.com/drugs/DB06228ApprovedInvestigationalHowever there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be taken with food. … Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary.
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: RIBEX® 15 MG, RIBEX® 10 MGPhenoxypropazine
go.drugbank.com/drugs/DB09251ApprovedWithdrawnPhenoxypropazine is a non-selective and irreversible monoamine oxidase enzyme inhibitor (MAOI), belonging to the _hydrazine_ chemical class. … It was marketed as an antidepressant in 1961 but was later withdrawn in 1966 because of its hepatotoxic potential.
Synonyms: (1-METHYL-2-PHENOXYETHYL)HYDRAZINE, HYDRAZINE, (1-METHYL-2-PHENOXYETHYL)-Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeRice bran
go.drugbank.com/drugs/DB14361ApprovedRice bran is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Mixtures: Ari S-LinerAmoxapine
go.drugbank.com/drugs/DB00543ApprovedAmoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. … The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic IndexSynonyms: 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepineSecretin human
go.drugbank.com/drugs/DB09532ApprovedInvestigationalPurified synthetic human secretin, also referred to as RG1068, is available as an intravenous injection under the market name ChiRhoStim ® in the U.S.. … The hormone is produced from the enterochromaffin cells in the duodenum in response to the duodenal content with the pH less than 4.5 [L1875].
Butalbital
go.drugbank.com/drugs/DB00241ApprovedIllicitDue to these risks, the use of butalbital-containing combination products is typically limited for use only in cases where other medications are deemed ineffective and such usage is advised to be carefully … Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group.
Mixtures: Vanatol S, Fiorinal-C 1/4Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 Inducers