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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
go.drugbank.com/bio_entities/BE0000525TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371).
Synonyms: Complex I-B16.6Tetrahydrocannabivarin
go.drugbank.com/drugs/DB11755InvestigationalTetrahydrocannabivarin (THCV) is a propyl analogue of tetrahydrocannabinol (Δ9-THC), one of the primary pharmacological components of [Medical Cannabis]. … THCV is one of four cannabinoids with identified potential as anticonvulsant agents, which also includes Δ9-tetrahydrocannabinolic acid, [Cannabidiol] (CBD), and [Cannabidivarin] (CBDV) [A33334].
Baculoviral IAP repeat-containing protein 3
go.drugbank.com/bio_entities/BE0010674TargetHumansProtects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.
Synonyms: TNFR2-TRAF-signaling complex protein 1Pitavastatin
go.drugbank.com/drugs/DB08860ApprovedInvestigationalThe clear evidence of the benefit of statin use coupled with very minimal side effects or long term effects has resulted in this class becoming one of the most widely prescribed medications in North America
Barnidipine
go.drugbank.com/drugs/DB09227InvestigationalIt is available in modified-release oral tablets under the brand name Vasexten to be taken once daily in the morning. … Compared to several other calcium antagonists which are racemates, the barnidipine compound consisting of a single enantiomer may offer a high degree of pharmacological selectivity [A31567].
RuvB-like 2
go.drugbank.com/bio_entities/BE0009019TargetHumansMay play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026) … Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910
Synonyms: INO80 complex subunit JAvobenzone
go.drugbank.com/drugs/DB09495ApprovedInvestigationalAvobenzone is dibenzoyl methane derivative. It is oil soluble ingredient. Avobenzone has the ability to absorb ultraviolet light over wider range of wavelengths. It is included in many commercially available sunscreens which are used as ...
Mixtures: Sweet Pea Sheer Shield SPF45, Signature Body Sweet Pea SPF 15Insulin lispro
go.drugbank.com/drugs/DB00046ApprovedInvestigationalBolus insulin is often combined with once daily, long-acting "basal insulin" such as [DB01307], [DB09564], or [DB00047] to provide low concentrations of background insulin that can keep blood sugar stable … These biochemical changes result in a reduced tendency for self-association resulting in dissolution to a dimer and then to a monomer that is absorbed more rapidly after subcutaneous injection compared
Insulin glulisine
go.drugbank.com/drugs/DB01309ApprovedBolus insulin is often combined with once daily, long-acting "basal insulin" such as [DB01307], [DB09564], and [DB00047] to provide low concentrations of background insulin that can keep blood sugar stable … [L12519] These structural modifications decrease hexamer formation, stabilize insulin glulisine monomers and increase the rate of absorption and onset of action compared to human insulin.
Simeprevir
go.drugbank.com/drugs/DB06290ApprovedWithdrawnAdministered once daily with food, 150mg simeprevir capsule is used in combination with [DB08934] in patients with HCV genotype 1 without cirrhosis for 12 week duration. … Since the viral protease NS3/4A complex is essential for cleaving the HCV encoded polyprotein into individual viral proteins facilitating replication [A19632], the drug blocks the viral replication process