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Displaying results 1771 - 1780 of 10000 in total
  1. Drug

    Epoprostenol

    go.drugbank.com/drugs/DB01240
    ApprovedInvestigational

    It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.

    Synonyms: (5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate, (5Z,9α,11α,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acidProducts: VELETRI® 1.5 MG, VELETRI®0.5 MG
  2. Drug

    Ribociclib

    go.drugbank.com/drugs/DB11730
    ApprovedInvestigational

    Ribociclib was approved by the FDA in March 2017 under the brand name Kisqali. … Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6).

    Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesProducts: KISQALI (200 MG), KISQALI 200 MG TABLETAS RECUBIERTAS
  3. Drug

    Polyvinyl alcohol

    go.drugbank.com/drugs/DB11060
    Approved

    It has varying roles in commercial and industrial applications such as papermaking, textiles, and printing. … Polyvinyl alcohol is found in ophthalmic solutions as a lubricant to prevent irritation or to relieve dryness of the eyes [L2826].

    Mixtures: SICCAPROTECT 10 ML GOZ DAMLASI, Premier Value Eye Drops MtCategories: Compounds used in a research, industrial, or household setting
  4. Drug

    Isradipine

    go.drugbank.com/drugs/DB00270
    Approved

    It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells … It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsProducts: DYNACIRC SRO 5 MG, DYNACIRC COMPRIMIDOS 2.5 MG
  5. Drug

    Brompheniramine

    go.drugbank.com/drugs/DB00835
    Approved

    Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.

    Mixtures: M-end Wc, M-end PECategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 Substrates
  6. Drug

    Mifepristone

    go.drugbank.com/drugs/DB00834
    ApprovedInvestigational

    Currently under investigation for use in psychotic depression (phase 3 trials). … As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersProducts: MIFEPRISTONA 200 MG, MIFEPRISTONE 200 MG
  7. Drug

    Lanatoside C

    go.drugbank.com/drugs/DB13467
    Investigational

    Products: CETO-SANOL DAMLA, 10 ML, CETO-SANOL DAMLA, 50 ML
  8. Drug

    Selpercatinib

    go.drugbank.com/drugs/DB15685
    ApprovedInvestigational

    [A202049, A202055, A202052, L13604] Although selpercatinib is currently still under investigation in clinical trial NCT04211337, it was granted accelerated FDA approval on May 8, 2020, for specific … Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in RET-driven cancers, their lack of specificity is generally associated

    Categories: Rearranged during Transfection (RET) Inhibitors, Cytochrome P-450 SubstratesSynonyms: 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
  9. Drug

    Almotriptan

    go.drugbank.com/drugs/DB00918
    Approved

    It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and stopping the release of certain natural substances that cause pain, nausea, and other symptoms … Almotriptan is in a class of medications called selective serotonin receptor agonists.

    Categories: Heterocyclic Compounds, 2-Ring, Serotonin 5-HT1 Receptor AgonistsSynonyms: 1-(((3-(2-(Dimethylamino)ethyl)indol-5-yl)methyl)sulfonyl)pyrrolidine
  10. Drug

    Verteporfin

    go.drugbank.com/drugs/DB00460
    ApprovedInvestigational

    Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative comprising a 50:50 mixture of two isomers: [CL-315555] and [CL-315585]. … It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration.

    Categories: Heterocyclic Compounds with 4 or More RingsProducts: VISUDYNE FOR INJECTION 15 mg/vial, VISUDYNE 15 MG INFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN TOZ