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Methylphenobarbital
go.drugbank.com/drugs/DB00849ApprovedA barbiturate that is metabolized to phenobarbital. It has been used for similar purposes, especially in epilepsy, but there is no evidence mephobarbital offers any advantage over phenobarbital.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersSynonyms: 5-ethyl-1-methyl-5-phenylbarbituric acid, 5-Ethyl-1-methyl-5-phenyl-pyrimidine-2,4,6-trioneOxogluric acid
go.drugbank.com/drugs/DB08845InvestigationalNutraceuticalSeveral experimental studies have also shown that administration of oxogluric acid helped attenuate the decreased synthesis of muscle protein that is often seen post-surgery. … In the United States a phase I clinical trial is investigating whether oxogluric acid precursors found in nutritional supplements can benefit patients with the metabolic disorder propionic acidemia.
Synonyms: 2-Ketoglutaric acid, 2-oxoglutaric acidGenistein
go.drugbank.com/drugs/DB01645InvestigationalIt has been determined to be the active ingredient in <I>Felmingia vestita</I>, which is a plant traditionally used against worms. … Further, genistein is a phytoestrogen which has selective estrogen receptor modulator properties.
Mixtures: CALCIDAY G 1200 MG/800 IU/50 MG EFERVESAN TABLET, 45 ADET, CALCÄ°DAY G 1000 MG/880 IU/50 MG EFERVESAN TABLET, 40 ADETCategories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesEdrophonium
go.drugbank.com/drugs/DB01010ApprovedA rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
Synonyms: 3-hydroxy-N,N-dimethyl-N-ethylanilinium, N-ethyl-3-hydroxy-N,N-dimethylaniliniumCategories: Compounds used in a research, industrial, or household settingFursultiamine
go.drugbank.com/drugs/DB08966ApprovedIt has also been suggested for several non-deficiency disorders but has not yet proven useful. Fursultiamine is a vitamin B1 derivative.
International brands: Alinamin FMixtures: ALINAMIN-F ODORLESS TABLETDasabuvir
go.drugbank.com/drugs/DB09183ApprovedWhen combined together, Dasabuvir [DB09296], [DB09297], and [DB00503] as the combination product Viekira Pak have been shown to achieve a SVR of 100% for genotype 1b and 89% or 95% for genotype 1a after … Dasabuvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV).
Synonyms: Sodium 3-(3-tert-butyl-4-methoxy-5-{6Â [(methylsulfonyl)amino]naphthalene-2-yl}phenyl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ide hydrate (1:1:1), N-{6-[3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl]naphthalen-2-yl}methanesulfonamideCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSuprofen
go.drugbank.com/drugs/DB00870ApprovedWithdrawnIt inhibits prostaglandin synthesis and has been proposed as an anti-arthritic. It is no longer approved for use in the United States.
Categories: Non COX-2 selective NSAIDS, Cytochrome P-450 SubstratesSynonyms: 2-(4-(2-Thenoyl)phenyl)propionsäure, (±)-2-(p-(2-thenoyl)phenyl)propionic acidRofecoxib
go.drugbank.com/drugs/DB00533ApprovedWithdrawnThe proteins that rofecoxib target include elastin and prostaglandin G/H synthase 2. … Cytochrome P450 1A2, Cytochrome P450 3A4, Cytochrome P450 2C9, Cytochrome P450 2C8, and Prostaglandin G/H synthase 1 are known to metabolize rofecoxib.
Categories: COX-2 Inhibitors, Cytochrome P-450 SubstratesSynonyms: 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanoneFluorouracil
go.drugbank.com/drugs/DB00544ApprovedInvestigationalA pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Mixtures: Actikerall 5 mg/g + 100 mg/g Lösung zur Anwendung auf der Haut, VERRUTOL %0,5 + %10 DERİ ÇÖZELTİSİ (15 G)Categories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic IndexAmiloride
go.drugbank.com/drugs/DB00594ApprovedInvestigationalA pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. … This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct.
Mixtures: PLENACOR D, MODURETIC® TABLETASCategories: Decreased Renal K+ Excretion, Heterocyclic Compounds, 1-Ring