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Displaying results 171 - 180 of 134683 in total
  1. Pathway

    Verapamil Action Pathway

    smpdb.ca/view/SMP0000375
    Drug action

    Sodium channels then close and rapidly activated potassium channels such as the voltage-gated transient outward delayed rectifying potassium channel (I-Kto) and the voltage-gated ultra rapid delayed rectifying … Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium

    Drugs: ATP · Verapamil · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  2. Pathway

    Nifedipine Action Pathway

    smpdb.ca/view/SMP0000379
    Drug action

    Activated mysoin light chain kinase (MLCK) is required for muscle contraction since it can catalyze the phosphorylation of the regulatory light chain subunit of myosin. … Without calcium ions in muscle cell, calmodulin couldn't form the calcium-bound calmodulin, which is required for binding and activating MLCK.

    Drugs: ATP · Nifedipine · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  3. Pathway

    Nimodipine Action Pathway

    smpdb.ca/view/SMP0000380
    Drug action

    This may be due to its high lipophilicity and ability to penetrate the blood brain barrier. … Activated mysoin light chain kinase (MLCK) is required for muscle contraction since it can catalyze the phosphorylation of the regulatory light chain subunit of myosin.

    Drugs: ATP · Nimodipine · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  4. Pathway

    Nisoldipine Action Pathway

    smpdb.ca/view/SMP0000381
    Drug action

    Activated mysoin light chain kinase (MLCK) is required for muscle contraction since it can catalyze the phosphorylation of the regulatory light chain subunit of myosin. … Without calcium ions in muscle cell, calmodulin couldn't form the calcium-bound calmodulin, which is required for binding and activating MLCK.

    Drugs: ATP · Nisoldipine · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  5. Pathway

    Carteolol Action Pathway

    smpdb.ca/view/SMP0000658
    Drug action

    Adrenaline (also known as epinephrine) can activate β1 adrenergic receptor so that the heart rate and output will be increased. … Carteolol (also known as Cartrol or Ocupress) is a selective β1 adrenergic receptor antagonist (beta blocker), which can be used for treatment of high blood pressure (hypertension) and irregular heartbeats

    Drugs: ATP · Carteolol · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  6. Pathway

    Timolol Action Pathway

    smpdb.ca/view/SMP0000659
    Drug action

    Around the cell there are many transports happening through many different transporters, leading in and out of the cell Some of the transports into the cell include sodium and calcium, while transports … The calcium and calmodulin then activate myosin light chain kinase, which is located in the smooth vascular muscle.

    Drugs: ATP · Timolol · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  7. Pathway

    Dobutamine Action Pathway

    smpdb.ca/view/SMP0000662
    Drug action

    Dobutamine is a type of medication that can be used for treating heart failure and cardiogenic shock. … Dobutamine can bind to beta-1 adrenergic receptor on the heart cell which lead to mild chronotropic, arrhythmogenic, hypertensive and vasodilative effects.

    Drugs: ATP · Dobutamine · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  8. Pathway

    Levobunolol Action Pathway

    smpdb.ca/view/SMP0000666
    Drug action

    decreased blood pressure, heart rate and cardiac output. … Levobunolol bind to beta1-adrenergic and beta2-adrenergic receptors in heart and vascular smooth muscle to block the binding of other adrenergic neurotransmitters such as norepinephrine, which lead to

    Drugs: ATP · Levobunolol · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  9. Pathway

    Metipranolol Action Pathway

    smpdb.ca/view/SMP0000667
    Drug action

    Metipranolol binds to beta1-adrenergic and beta2-adrenergic receptors in heart and vascular smooth muscle. … Metipranolol demonstrates low intrinsic sympathomimetic activity, and weak local anesthetic (membrane-stabilizing) and myocardial depressant activity.

    Drugs: ATP · Metipranolol · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  10. Pathway

    Practolol Action Pathway

    smpdb.ca/view/SMP0000669
    Drug action

    , heart rate and cardiac output. … In juxtaglomerular apparatus, practolol can prevent the production of aldosterone and angiotensin II by inhibiting renin production, which lead to prevention of water retention and vasoconstriction.

    Drugs: ATP · Practolol · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4