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Desloratadine H1-Antihistamine Action
smpdb.ca/view/SMP0060201Drug actionReducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression
Enzymes: Protein kinase C beta type, Guanine nucleotide-binding protein G(q) subunit alphaCetirizine H1-Antihistamine Action
smpdb.ca/view/SMP0059058Drug actionReducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression
Enzymes: Protein kinase C beta type, Guanine nucleotide-binding protein G(q) subunit alphaFexofenadine H1-Antihistamine Action
smpdb.ca/view/SMP0060218Drug actionReducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression
Enzymes: Protein kinase C beta type, Guanine nucleotide-binding protein G(q) subunit alphaLoratadine H1-Antihistamine Action
smpdb.ca/view/SMP0060195Drug actionReducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression
Enzymes: Protein kinase C beta type, Guanine nucleotide-binding protein G(q) subunit alphaQuetiapine H1-Antihistamine Action
smpdb.ca/view/SMP0062884Drug actionReducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression
Enzymes: Protein kinase C beta type, Guanine nucleotide-binding protein G(q) subunit alphaAcute Intermittent Porphyria
smpdb.ca/view/SMP0000344DiseaseThe HMBS gene codes for the protein hydroxymethylbilane synthase (porphobilinogen deaminase) which catalyzes the synthesis of porphobilinogen into hydroxymethylbilane.
Enzymes: Cytochrome c oxidase assembly protein COX15 homolog, Feline leukemia virus subgroup C receptor-related protein 2Chlorphenamine H1-Antihistamine Action
smpdb.ca/view/SMP0056661Drug actionReducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression
Enzymes: Protein kinase C beta type, Guanine nucleotide-binding protein G(q) subunit alphaAcute Intermittent Porphyria
smpdb.ca/view/SMP0125644DiseaseThe HMBS gene codes for the protein hydroxymethylbilane synthase (porphobilinogen deaminase) which catalyzes the synthesis of porphobilinogen into hydroxymethylbilane.
Enzymes: Cytochrome c oxidase assembly protein COX15 homolog, Feline leukemia virus subgroup C receptor-related protein 2Orphenadrine Drug Action
smpdb.ca/view/SMP0058808Drug actionReducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression
Enzymes: Protein kinase C beta type, Guanine nucleotide-binding protein G(q) subunit alphaNoncanonical Wnt/Ca2+ signaling
smpdb.ca/view/SMP0468891SignalingDAG and calcium activate protein kinase C (PKC), which in turn activates cell-division cycle 43 (Cdc42). … This causes the G-protein to activate phospholipase C (PLC), which then cleaves phosphatidylinositol-4,5-bisphosphate (PIP₂) into diacylglycerol (DAG) and inositol-1,4,5-trisphosphate (IP₃).
Enzymes: Protein kinase C beta type, Protein kinase C alpha type