Search
Ranolazine
go.drugbank.com/drugs/DB00243ApprovedInvestigational[L3580] With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.[L5440] … Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities.
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsProducts: RANEXICOR ® 1000, CIVENISTU® 1000Isoconazole
go.drugbank.com/drugs/DB08943ApprovedIsoconazole is an azole antifungal drug that has similar effectiveness to clotrimazole in the treatment of foot and vaginal infections.
Mixtures: TİNAGEN 1 MG+10 MG/1 G DERİ KREMİ, 15 G, TRODERM 10 MG/G+1 MG/G KREM ,15 GCategories: Heterocyclic Compounds, 1-RingProchlorperazine
go.drugbank.com/drugs/DB00433ApprovedInvestigationalVet approvedProchlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management … Although newer antiemetic agents such as 5-HT3 antagonists are more heavily promoted, prochlorperazine is still widely used in nausea and vomiting.[L6640]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine, 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazineHistrelin
go.drugbank.com/drugs/DB06788ApprovedInvestigationalWithdrawnAs the product Supprelin LA, histrelin is indicated for the treatment of CPP in children (approved by the FDA in May 2007).[L41700] … This drug is a synthetic analog of naturally occurring GnRH with a higher potency.
Synonyms: 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-Nτ-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamideInternational brands: Supprelin LAChlorprothixene
go.drugbank.com/drugs/DB01239ApprovedInvestigationalWithdrawnChlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class. … Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.
Categories: P-glycoprotein inhibitors, Heterocyclic Compounds, 3-RingProducts: CHLORPROTHIXEN-NEURAX 100, Truxal 15 mg - FilmtablettenLisdexamfetamine
go.drugbank.com/drugs/DB01255ApprovedInvestigationalLisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine,[A40246] covalently attached to the naturally occurring amino acid L-lysine. … [A2230] Lisdexamfetamine is the first chemically formulated prodrug stimulant [A40246] and was first approved by the FDA in April 2008.[A2230] It was also approved by Health Canada in February 2009.
Products: VYVANSE® 20 MG CAPSULAS, VYVANSE CAPSULES 20 mgTucatinib
go.drugbank.com/drugs/DB11652ApprovedInvestigationalIt was developed by Seattle Genetics and approved by the FDA on April 17, 2020. … Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer.
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsProducts: TUKYSA 150 mg film-coated tablets, TUKYSA (TUCATINIB) FILM-COATED TABLETS 150 mgBromelains
go.drugbank.com/drugs/DB13281ApprovedInvestigationalIt is considered as a safe food supplement. … Bromelain is a protease enzyme derived from the stems of pineapples that is composed of a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase
Mixtures: BIOGROW® VITE, PLASIL®ENZIMATICOProducts: Bromelain Pineapple Enzyme 50 Mg Nu Life, Bromelain 500 (300gdu/capsule)Brimonidine
go.drugbank.com/drugs/DB00484ApprovedInvestigational[A178951] It is considered to be a third generation alpha-2 aadrenergic receptor agonist, since it displays preferential binding at alpha-2 adrenoceptors over alpha-1 receptors. … [A179002] Brimonidine displays a higher selectivity toward the alpha-2 adrenergic receptors than [clonidine] or [apraclonidine], which are also alpha-2 adrenergic agonists.
Mixtures: SIMBRINZA EYE DROPS, SUSPENSION 10 MG/ML + 2 MG/ML, SİMBRİNZA 10 MG/ML + 2 MG/ML GÖZ DAMLASI, SÜSPANSİYON, 5 MLCategories: Heterocyclic Compounds, 2-Ring, Adrenergic alpha-2 Receptor AgonistsThalidomide
go.drugbank.com/drugs/DB01041ApprovedInvestigationalWithdrawnA piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. … It has been reintroduced and used for a number of inflammatory disorders and cancers.
Synonyms: 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline, α-N-phthalylglutaramideInternational brands: Pro-ban M, K-17