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Histrelin
go.drugbank.com/drugs/DB06788ApprovedInvestigationalWithdrawnThis drug is a synthetic analog of naturally occurring GnRH with a higher potency. … As the product Supprelin LA, histrelin is indicated for the treatment of CPP in children (approved by the FDA in May 2007).[L41700]
Synonyms: [(im-Bzl)-D-His6,Pro9-NEt]-gonadotropin releasing hormone, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamideRuxolitinib
go.drugbank.com/drugs/DB08877ApprovedInvestigationalIt is a potent and selective inhibitor of JAK1 and JAK2,[A229698] which are tyrosine kinases involved in cytokine signalling and hematopoiesis. … Ruxolitinib, formerly known as INCB018424 or INC424, is an anticancer drug and a Janus kinase (JAK) inhibitor.
Categories: Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: JAKAVI 5 MG (TABLETS), JAKAVI® 10MG TABLETASDonislecel
go.drugbank.com/drugs/DB17961Approved[L47166,L47196] The approval of donislecel was based on the safety and effectiveness evaluated in 2 clinical trials with 30 type 1 diabetic patients. … [L47196] Donislecel was approved by the FDA on June 28, 2023, and is available under the brand name LANTIDRA from CellTrans Inc.[L47196]
Categories: Drugs Used in DiabetesAmcinonide Action Pathway
smpdb.ca/view/SMP0126169Drug actionAmcinonide is a topical corticosteroid used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Amcinonide is a selective glucocorticoid receptor (GC) agonist. By binding to the glucoco...
Enzymes: Prostaglandin E synthaseBudesonide Action Pathway
smpdb.ca/view/SMP0126182Drug actionBudesonide is a corticosteroid used to treat Crohn's disease, asthma, COPD, hay fever, allergies, and ulcerative colitis. Budesonide was granted FDA approval on 14 February 1994. This drug is available as an extended-release capsule, as ...
Enzymes: Prostaglandin E synthaseClocortolone Action Pathway
smpdb.ca/view/SMP0126193Drug actionClocortolone, brand name Cloderm, is a corticosteroid used as a topical cream to treat inflammatory and pruritic dermatoses of the scalp. Clocortolone is a moderate potency topical corticosteroid that should not be used with occlusive dr...
Enzymes: Prostaglandin E synthaseDesonide Action Pathway
smpdb.ca/view/SMP0126223Drug actionDesonide is a nonfluorinated synthetic corticosteroid used for the treatment of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. It is administered as a cream, ointment, lotion, gel, or as foam. The drug ...
Enzymes: Prostaglandin E synthaseDexamethasone Action Pathway
smpdb.ca/view/SMP0126226Drug actionThis drug is similar in structure to other corticosteroids like hydrocortisone and prednisolone. … Dexamethasone, also known as MK-125, is a fluorinated glucocorticoid available in various modes of administration (tablet, intravenous injections, eye drops, and intramuscular injections) that is used
Enzymes: Prostaglandin E synthaseFluocinonide Action Pathway
smpdb.ca/view/SMP0126234Drug actionFluocinonide is a topical corticosteroid used for a number of inflammatory skin conditions (corticosteroid-responsive dermatoses). Fluocinonide binds to the cytosolic glucocorticoid receptor. As this molecule is a glucocorticoid, its mec...
Enzymes: Prostaglandin E synthaseFlurandrenolide Action Pathway
smpdb.ca/view/SMP0126235Drug actionFlurandrenolide is a topical corticosteroid used to treat various skin conditions (corticosteroid-responsive dermatoses). This drug is usually employed as a cream, an ointment or as a polyethylene tape with an adhesive. Flurandrenolide i...
Enzymes: Prostaglandin E synthase