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Sodium phosphate, dibasic
go.drugbank.com/drugs/DB14502ApprovedInvestigationalMixtures: Tis-U-Sol, Tis-U-solDronedarone
go.drugbank.com/drugs/DB04855ApprovedInvestigationalA safety concern for the risk of drug-induced hepatocellular injury has been issued following marketing of dronedarone.[L8800] … Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management.
Categories: Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexTolazamide
go.drugbank.com/drugs/DB00839ApprovedA sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide.
Categories: combinations of sulfonamidesThrombin alfa
go.drugbank.com/drugs/DB11572ApprovedNevertheless, because the incidence of hemostasis within a timely manner is relatively comparable between the use of thrombin alfa and the placebo treatment in patient subjects, thrombin alfa is not currently … The cell culture process used in the manufacture of Thrombin Alfa employs no additives of human or animal origin.
Gepirone
go.drugbank.com/drugs/DB12184ApprovedAlthough earlier clinical trials showed promising results for gepirone, its formulation as an immediate-release tablet necessitates frequent administration due to the short half-lives. … side effects as that of the placebo.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeMechlorethamine
go.drugbank.com/drugs/DB00888ApprovedInvestigationalEach tube of Valchlor contains 0.016% of mechlorethamine which is equivalent to 0.02% mechlorethamine HCl. … A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas.
Categories: Compounds used in a research, industrial, or household setting, Weapons of Mass DestructionIslatravir
go.drugbank.com/drugs/DB15653ApprovedInvestigationaladults who are virologically suppressed on a stable antiretroviral regimen. … [L56141] This formulation represents a significant advance in long-acting oral therapy due to islatravir's exceptionally long intracellular half-life, which allows for extremely low dosing.
Glucarpidase
go.drugbank.com/drugs/DB08898ApprovedInvestigationalThis can lead to delayed renal clearance of methotrexate and elevated drug plasma levels, increasing the risk of methotrexate toxicity. … [A7476,A7477] After the discovery of certain bacteria with the capacity to inactivate folate analogs such as methotrexate, carboxypeptidase G was identified and Carboxypeptidase G1 was first isolated
Quaternium-15
go.drugbank.com/drugs/DB14198ApprovedIt is an anti-microbial agent by virtue of being a formaldehyde releaser, however this can also cause contact dermatitis, a symptom of an allergic reaction, especially in those with sensitive skin. … Quaternium-15 is a quaternary ammonium salt used as a surfactant and preservative in many products including cosmetics.
Elvitegravir
go.drugbank.com/drugs/DB09101ApprovedInvestigationalAlthough available as a single dose tablet, elvitegravir must be used in combination with an HIV protease inhibitor coadministered with ritonavir and another antiretroviral drug. … Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults.
Categories: Antivirals used in combination for the treatment of HIV infections