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Displaying results 1811 - 1820 of 10000 in total
  1. Drug

    Mycophenolate mofetil

    go.drugbank.com/drugs/DB00688
    ApprovedInvestigational

    It demonstrates an increased bioavailability, a higher efficacy, and reduced gastrointestinal effects when compared to MPA.[A180826] … Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH).

    Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: 2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
  2. Indication

    Proteinuria

    go.drugbank.com/conditions/DBCOND0018907
    Drugs: Atacicept · Atrasentan · Budesonide · Diltiazem · Hydrocortisone · Hydrocortisone succinate +3 more
    Synonyms: Increased protein in urine, Abnormal presence of protein in urine
  3. Target

    Serine/threonine-protein kinase Nek1

    go.drugbank.com/bio_entities/BE0009496
    TargetHumans

    Involved in cilium assembly (PubMed:21211617) … In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity).

    Synonyms: Never in mitosis A-related kinase 1
  4. Drug

    Sildenafil

    go.drugbank.com/drugs/DB00203
    ApprovedInvestigational

    Regardless, sildenafil, among a variety of other similar or related PDE5 inhibitors, has become a common and effective treatment for erectile dysfunction and since its formal approval for medical use in … Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment for angina - or chest pain associated with inadequate blood flow to the heart -

    Mixtures: DAPOKSEL 30 MG/50 MG FILM TABLET ,3 FILM TABLET, DAPOKSEL 30 MG/50 MG FILM TABLET ,6 FILM TABLETCategories: Drugs Used in Erectile Dysfunction, P-glycoprotein inhibitors
  5. Drug

    Mecobalamin

    go.drugbank.com/drugs/DB03614
    ApprovedInvestigational

    Mixtures: EnLyte Extra-LN, Protect Cardio AFCategories: Vitamin B Complex, Heterocyclic Compounds, 1-Ring
  6. Drug

    Amantadine

    go.drugbank.com/drugs/DB00915
    ApprovedInvestigational

    An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. … The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.

    Mixtures: BREGAMIN AV, BREGAMIN AVCategories: Influenza A M2 Protein Inhibitor
  7. Drug

    Letrozole

    go.drugbank.com/drugs/DB01006
    ApprovedInvestigational

    Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990. … [A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine.

    Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: SOLESTRASA-IN, Ag-letrozole
  8. Indication

    Hypocitraturic calcium oxalate nephrolithiasis

    go.drugbank.com/conditions/DBCOND0023599
    Drugs: Potassium citrate
    Synonyms: Other abnormal findings in urine
  9. Drug

    Losartan

    go.drugbank.com/drugs/DB00678
    ApprovedInvestigational

    [L7423] Losartan is available as losartan potassium oral tablets as well as a combination tablet of losartan potassium and hydrochlorothiazide. … Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension.

    Mixtures: Ag-losartan Hctz, Ag-losartan HctzCategories: Angiotensin II Type 1 Receptor Blockers, Angiotensin II Type 2 Receptor Blockers
  10. Drug

    Duloxetine

    go.drugbank.com/drugs/DB00476
    ApprovedInvestigational

    Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. … [A178741] Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder.

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: (3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine, (S)-duloxetine