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Displaying results 1811 - 1820 of 10000 in total
  1. Drug

    Zilganersen

    go.drugbank.com/drugs/DB18161
    ApprovedInvestigational

    [L64096] It is administered by intrathecal injection, and requires dilution with an accompanying artificial cerebrospinal fluid diluent before administration. … [L64096] Alexander disease is caused by variants in the *GFAP* gene that lead to overproduction and toxic accumulation of GFAP in astrocytes, and dysfunction in astrocytes can over time damage neurons

  2. Drug

    Desipramine

    go.drugbank.com/drugs/DB01151
    Approved

    The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. … They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation.

    Categories: Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index, Combined Inhibitors of Serotonin/Norepinephrine ReuptakeProducts: DESIPRAM 25 MG TABLET, 100 ADET
  3. Drug

    Propiolactone

    go.drugbank.com/drugs/DB09348
    ApprovedWithdrawn

    [A32144] It is currently FDA approved for its use as an indirect additive used in food contact substances. Propiolactone was first commercially available in the United States in 1958.[A32144] … Propiolactone is a lactone compound with a four-membered ring. It is a colorless liquid with a pungent slightly sweet odor.

    Categories: Compounds used in a research, industrial, or household setting
  4. Drug

    Somatrogon

    go.drugbank.com/drugs/DB14960
    ApprovedInvestigational

    [L39362] In October 2021, Health Canada approved somatrogon under the market name NGENLA as the long-term treatment of pediatric patients who have growth failure due to an inadequate secretion of endogenous … [L47153,L47158] Somatrogon is available as a once-weekly subcutaneous injection.[L39080,L47153]

    Synonyms: HUMAN GROWTH HORMONE-CARBOXY-TERMINAL PEPTIDE (CTP) OF THE BETA CHAIN OF HUMAN CHORIONIC GONADOTROPIN FUSION PROTEIN, FUSION PROTEIN OF HUMAN CHORIOGONADOTROPIN SUBUNIT .BETA.Products: NGENLA 24 MG/1,2 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR KALEM, 1 ADET, NGENLA 60 MG/1,2 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR KALEM, 1 ADET
  5. Drug

    Amlexanox

    go.drugbank.com/drugs/DB01025
    ApprovedWithdrawn

    Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. … Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers.

    International brands: OraDisc A
  6. Drug

    Ciclesonide

    go.drugbank.com/drugs/DB01410
    ApprovedInvestigational

    Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco.

    Mixtures: DUESONIT 18/200 MCG INHALASYON ICIN TOZ ICEREN KAPSUL, 60 ADET, DUESONIT 18/200 MCG INHALASYON ICIN TOZ ICEREN KAPSUL, 120 ADETProducts: SONICAD 200 MCG İNHALASYON İÇİN TOZ İÇEREN KAPSÜL, 120 ADET, SONICAD 200 MCG İNHALASYON İÇİN TOZ İÇEREN KAPSÜL, 60 ADET
  7. Drug

    Ethylmorphine

    go.drugbank.com/drugs/DB01466
    IllicitInvestigational

    A narcotic analgesic and antitussive. It is metabolized in the liver by ethylmorphine-N-demethylase and used as an indicator of liver function. … In the US it is a schedule II drug (single-entity) and schedule III drug (in combination products).

    Mixtures: ARKODIN TABLET, 15 ADET, LUDICODINE TABLET, 15 ADETCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
  8. Drug

    Sulfoxone

    go.drugbank.com/drugs/DB01145
    Approved

    Sulfoxone is a water-soluble sulfone used as an antileprosy drug. It has been used with limited success in the treatment of dermatitis herpetiformis.

    Categories: Drugs for Treatment of Lepra
  9. Target

    Glutamate receptor ionotropic, kainate 4

    go.drugbank.com/bio_entities/BE0000827
    TargetHumans

    Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel. Cannot form functional channels on its own (PubMed:8263508). Shows channel activity only in heteromeric assembly with GRIK1, GRIK2 and GRIK3 sub...

    Synonyms: KA1, Glutamate receptor KA-1
  10. Target

    Glutamate receptor ionotropic, kainate 5

    go.drugbank.com/bio_entities/BE0000828
    TargetHumans

    Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Cannot form functional channels on its own and produces channel activity only in...

    Synonyms: KA2, Glutamate receptor KA-2