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Fosdenopterin
go.drugbank.com/drugs/DB16628Approved(cPMP) - is interrupted. … [A230088] MoCD is incurable and median survival in untreated patients is approximately 36 months[A230088] - treatment, then, is focused on improving survival and maintaining neurological function.
Categories: MATE 1 Substrates, MATE 2 InhibitorsSynonyms: C(PMP)Vibegron
go.drugbank.com/drugs/DB14895ApprovedInvestigationalVibegron is a potent, selective beta-3 adrenergic receptor (β3) agonist that relaxes the detrusor smooth muscle of the bladder, thereby increasing bladder capacity. … [L28310] Vibegron is the second beta-3 adrenergic agonist approved for the treatment of overactive bladder following [mirabegron], which was approved in 2012.
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesNylidrin
go.drugbank.com/drugs/DB06152ApprovedWithdrawnNylidrin is a peripheral vasodilator. … Nylidrin is utilized to treat several disorders that may benefit from increased blood flow (for example, certain mental disorders, blood vessel disease due to diabetes, frostbite, night leg cramps, and
Categories: 2-Amino-1-Phenylethanol Derivatives, Cytochrome P-450 SubstratesZuranolone
go.drugbank.com/drugs/DB15490ApprovedInvestigationalZuranolone is a neuroactive steroid that acts as a positive allosteric modulator of the GABA<sub>A</sub> receptors. … [A260791] Zuranolone was approved by the FDA on August 4th, 2023, and it is currently the only approved treatment for women with postpartum depression.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingOlsalazine
go.drugbank.com/drugs/DB01250ApprovedOlsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). … [A257063] Olsalazine is used in the treatment of ulcerative colitis.[L45023,L45151]
Categories: Non COX-2 selective NSAIDSEnfuvirtide
go.drugbank.com/drugs/DB00109ApprovedInvestigationalEnfuvirtide is a 36 amino acid biomimetic peptide that is structurally similar to the HIV proteins that are responsible for the fusion of the virus to cell membranes and subsequent intracellular uptake … The first agent in the novel class of antiretroviral drugs called HIV fusion inhibitors, enfuvirtide works by inhibiting HIV-1 fusion with CD4 cells.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 SubstratesProducts: FUZEON POLVO SOLUCION INYECTABLE 90 MG/MISulfamerazine
go.drugbank.com/drugs/DB01581ApprovedVet approvedWithdrawnA sulfanilamide that is used as an antibacterial agent.
Synonyms: N(1)-(4-Methyl-2-pyrimidinyl)sulfanilamide, 4-Amino-N-(4-methyl-2-pyrimidinyl)-benzenesulfonamideAtazanavir
go.drugbank.com/drugs/DB01072ApprovedInvestigationalAtazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. … Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV).
Mixtures: ANCEF ® R, ANCEF ® RCategories: P-glycoprotein inducers, P-glycoprotein inhibitorsCloxacillin
go.drugbank.com/drugs/DB01147ApprovedInvestigationalVet approvedA semi-synthetic penicillin antibiotic which is a chlorinated derivative of [oxacillin].
Categories: Heterocyclic Compounds, 2-RingSynonyms: (2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, (3-(o-chlorophenyl)-5-methyl-4-isoxazolyl)penicillinEsmolol
go.drugbank.com/drugs/DB00187ApprovedInvestigationalWithdrawnEsmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker. … It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses.
Categories: Cytochrome P-450 Substrates, Adrenergic beta-1 Receptor AntagonistsSynonyms: Methyl 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoate, 3-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-propionic acid methyl ester