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Displaying results 1821 - 1830 of 10000 in total
  1. Drug

    Conjugated estrogens

    go.drugbank.com/drugs/DB00286
    ApprovedInvestigational

    It also presents a large number of unidentified molecules with weak estrogenic activity as well as non-human molecules when it is obtained from pregnant mares urine. … [T475] The conjugated estrogen mixture was approved for marketing in US in 1942 based on the efficacy against certain conditions.

    Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: Premarin Inj 25mg/5ml, TROMODIL-V
  2. Indication

    Otoferlin Gene-mediated Hearing Loss

    go.drugbank.com/conditions/DBCOND0170571
    Drugs: Lunsotogene parvec
    Synonyms: Congenital Hearing Loss Secondary to Biallelic Mutations in the Otoferlin Gene (OTOF)
  3. Target

    Nucleoside diphosphokinase

    go.drugbank.com/bio_entities/BE0009626
    EnzymeHumans

    May also function as a Mg(2+)-dependent 3'-5' DNA exonuclease, excising nucleotides from 3' single-stranded DNA or DNA with 3' single strand overhangs, suggesting a role in DNA nucleolytic processing ( … Also functions as a histidine protein kinase by transferring the phosphoryl group from the phosphohistidine intermediate to a histidine residue in target proteins (PubMed:17157250, PubMed:20946858).

    Polypeptides: Nucleoside diphosphate kinase ASynonyms: NDPK A, NDP kinase A
  4. Indication

    Polyneuropathies

    go.drugbank.com/conditions/DBCOND0030109
    Drugs: Vutrisiran
    Synonyms: Other neurologic disorders in Lyme disease
  5. Indication

    Elevation of serum triglyceride levels

    go.drugbank.com/conditions/DBCOND0097366
    Drugs: Atorvastatin · Lovastatin · Pitavastatin · Pravastatin
    Synonyms: Increases in triglycerides, Increase in blood triglycerides
  6. Target

    Atrial natriuretic peptide receptor 1

    go.drugbank.com/bio_entities/BE0000556
    TargetHumans

    Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed:39543315). … Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499).

    Synonyms: ANP-A, ANPR-A
  7. Target

    Interferon-inducible protein AIM2

    go.drugbank.com/bio_entities/BE0011287
    TargetHumans

    Also acts as a regulator of neurodevelopment via its role in the DNA damage response: acts by promoting neural cell death in response to DNA damage in the developing brain, thereby purging genetically … Also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (By similarity).

    Synonyms: Absent in melanoma 2
  8. Drug

    Velmupressin

    go.drugbank.com/drugs/DB18783
    Investigational

    Synonyms: L-prolinamide, 4-chloro-n-(4-mercapto-1-oxobutyl)-l-phenylalanyl-3-(2-thienyl)-l-alanyl-l-valyl-l-asparaginyl-l-cysteinyl-n-(4-((aminoiminomethyl)amino)butyl)-, cyclic (1->5)-thioether
  9. Drug

    Tetracycline

    go.drugbank.com/drugs/DB00759
    ApprovedInvestigationalVet approvedWithdrawn

    The FDA withdrew its approval for the use of all liquid oral drug products formulated for pediatric use containing tetracycline in a concentration greater than 25 mg/ml. … Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsSynonyms: (4S,4aS,5aS,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
  10. Drug

    2-[3-(5-Mercapto-[1,3,4]thiadiazol-2yl)-ureido]-N-methyl-3-pentafluorophenyl-propionamide

    go.drugbank.com/drugs/DB07988
    Experimental

    Categories: Heterocyclic Compounds, 1-Ring