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Sparsentan
go.drugbank.com/drugs/DB12548ApprovedInvestigationalSparsentan is a dual antagonist of the endothelin type A receptor (ET<sub>A</sub>R) and the angiotensin II (Ang II) type 1 receptor (AT<sub>1</sub>R) with a similar affinity for both (9.3 nM for ET<sub … [A257330] In February 2023, the use of sparsentan to reduce proteinuria in adults with primary immunoglobulin A nephropathy (IgAN) at risk of rapid disease progression was approved by the FDA under
Categories: Angiotensin II Type 1 Receptor Blockers, Angiotensin II receptor antagonistsDyspnea
go.drugbank.com/conditions/DBCOND0024477Drugs: ReproterolSynonyms: Difficulty in breathing, DIB - Difficulty in breathingSimethicone
go.drugbank.com/drugs/DB09512ApprovedInvestigational[A228308] It has a favourable safety profile as it is not systemically absorbed.[A228308] Simethicone has been in use since the 1940s[A228303] but was granted FDA approval in 1952.[A228308] … Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination.
Mixtures: M A L D I M, E-Z-GAS II GRANULESCategories: Compounds used in a research, industrial, or household settingSacubitril
go.drugbank.com/drugs/DB09292ApprovedInvestigationalSacubitril is a prodrug neprilysin inhibitor used in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection … II.
Categories: Heterocyclic Compounds, 1-RingInborn Errors of Bile Acid Synthesis
go.drugbank.com/conditions/DBCOND0046673Drugs: Cholic AcidSynonyms: Inborn error in primary bile acid synthesisLambert Eaton Myasthenic Syndrome (LEMS)
go.drugbank.com/conditions/DBCOND0053084Drugs: AmifampridineSynonyms: Lambert-Eaton syndrome in neoplastic diseaseGlial cell line-derived neurotrophic factor
go.drugbank.com/bio_entities/BE0002486TargetHumansInvolved in the development of the neural crest (PubMed:15242795)
Polypeptides: Glial cell line-derived neurotrophic factorFunction: chemoattractant activity involved in axon guidanceChronic Myelomonocytic Leukemia
go.drugbank.com/conditions/DBCOND0028572Synonyms: Chronic myelomonocytic leukemia in transformation [obs], Chronic myelomonocytic leukaemia in transformation [obs]Asthenia
go.drugbank.com/conditions/DBCOND0004745Synonyms: Lacking in energy, Lacking in energy (finding)Etofenamate
go.drugbank.com/drugs/DB08984InvestigationalEtofenamate is used to treat muscle and joint paint. It is a non-steroidal anti-inflammatory drug (NSAID).
Mixtures: THERMO RHEUMON 100 MG/G + 10 MG/G KREM, 50 G, THERMOFLEX %10 + %1 KREM, 50 GCategories: Non COX-2 selective NSAIDS