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Colistimethate
go.drugbank.com/drugs/DB01111ApprovedInvestigationalVet approvedColistimethate is an antibiotic that has been shown to have bactericidal activity against aerobic gram-negative microorganisms.
Products: Coly-Mycin M, OLIXATO® 1 MIU POLVO LIOFILIZADO PARA INYECCIONTuroctocog alfa
go.drugbank.com/drugs/DB09109ApprovedTuroctocog alfa is a recombinant factor VIII (rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the N-terminus and 11 amino acids from the C-terminus of the naturally … occurring B-domain.
Products: NOVOEIGHT®500UI POLVO Y SOLVENTE PARA SOLUCIÓN INYECTABLE, NOVOEIGHT®1000 UI POLVO Y SOLVENTE PARA SOLUCIÓN INYECTABLEBerberine
go.drugbank.com/drugs/DB04115ApprovedInvestigationalWithdrawnAn alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. … It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal.
Categories: MATE 1 Substrates, P-glycoprotein substratesCiticoline
go.drugbank.com/drugs/DB12153ApprovedInvestigationalWithdrawnCiticoline is a donor of choline in biosynthesis of choline-containing phosphoglycerides. … It has been investigated for the treatment, supportive care, and diagnosis of Mania, Stroke, Hypomania, Cocaine Abuse, and Bipolar Disorder, among others.
Synonyms: Cytidine 5'-diphosphocholine, Cytidine-5'-diphosphocholineCategories: Heterocyclic Compounds, 1-RingPitavastatin
go.drugbank.com/drugs/DB08860ApprovedInvestigational[A181087,A181553] Use of statins to target and reduce LDL levels has been shown in a number of landmark studies to significantly reduce the risk of development of CVD and all-cause mortality. … [A181087, A181406] Evidence has shown that even for low-risk individuals (with <10% risk of a major vascular event occurring within 5 years) statins cause a 20%-22% relative reduction in major cardiovascular
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: พิทาซà¸à¸£à¹Œ 2, PITALIP(R)Sinecatechins
go.drugbank.com/drugs/DB01266ApprovedInvestigationalNutraceuticalIt is a partially purified fraction of the water extract of green tea leaves from Camellia sinensis, and is a mixture of catechins and other green tea components. … Sinecatechins is a botanical drug product for topical use.
Synonyms: Polyphenon ECategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingMonobenzone
go.drugbank.com/drugs/DB00600ApprovedWithdrawnMonobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. … It exerts a depigmenting effect on skin of mammals by increasing the excretion of melanin from the melanocytes. It may also cause destruction of melanocytes and permanent depigmentation.
Synonyms: 4-(Benzyloxy)phenol, 4-BenzyloxyphenolPhenformin
go.drugbank.com/drugs/DB00914ApprovedWithdrawnA biguanide hypoglycemic agent with actions and uses similar to those of metformin.
Synonyms: β-PhenethybiguanideCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesDihydroergocornine
go.drugbank.com/drugs/DB11273Approved[A32965] Dihydroergocornine presents a formula of 9,10 alpha-dihydro-12'-hydroxy-2',5'alpha-bis(1-methylethyl)-ergotaman-3',6',18-trione.
Categories: Ergot-derivative Dopamine Receptor Agonists, Cytochrome P-450 SubstratesPravastatin
go.drugbank.com/drugs/DB00175ApprovedInvestigational[L6142] Pravastatin is made through a fermentation process in which [mevastatin] is first obtained. … It was the first statin administered as the active form and not as a prodrug.[T274] This drug was developed by Sankyo Co.
Mixtures: PRAVAFEN® CAPSULASCategories: P-glycoprotein substrates