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Glyburide
go.drugbank.com/drugs/DB01016ApprovedInvestigationalGlyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II. It is typically given to patients who cannot be managed with the standard first line therapy, metformin. Glyburide stimulates insulin se...
Synonyms: 1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea, 1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylureaCategories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesMycophenolic acid
go.drugbank.com/drugs/DB01024ApprovedInvestigationalMycophenolic acid is a potent immunosuppressant agent that inhibits de novo purine biosynthesis. It was derived from Penicillium stoloniferum, and has also shown antibacterial, antifungal and antiviral properties. . Mycophenolic acid is ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesTolterodine
go.drugbank.com/drugs/DB01036ApprovedInvestigationalTolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors.
Synonyms: (+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl)-p-cresolCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesFenofibrate
go.drugbank.com/drugs/DB01039ApprovedInvestigationalFenofibrate is a fibric acid derivative like clofibrate and gemfibrozil. Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia. Fenofibrate was granted FDA approval on 31 December 1993.
Synonyms: Isopropyl (4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl)propionateCategories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesThalidomide
go.drugbank.com/drugs/DB01041ApprovedInvestigationalWithdrawnA piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thal...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersGatifloxacin
go.drugbank.com/drugs/DB01044ApprovedInvestigationalWithdrawnGatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under...
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP1A2 InhibitorsRifampin
go.drugbank.com/drugs/DB01045ApprovedInvestigationalRifampin, also known as rifampicin, is a broad-spectrum antimicrobial that was first discovered in 1965 and clinically used in 1968. Rifampin is used to treat tuberculosis and works by inhibiting the microbial DNA-dependent RNA polymeras...
Categories: P-glycoprotein inducers, Cytochrome P-450 CYP1A2 InducersPromethazine
go.drugbank.com/drugs/DB01069ApprovedInvestigationalPromethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of phenothiazine that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indicatio...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesTegaserod
go.drugbank.com/drugs/DB01079ApprovedWithdrawnNovartis' brand name Zelnorm (tegaserod) had originally received approval from the US FDA in 2002 for the treatment of irritable bowel syndrome with constipation (IBS-C). It was, however, voluntarily withdrawn from widespread use in the ...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesVigabatrin
go.drugbank.com/drugs/DB01080ApprovedInvestigationalVigabatrin is an analog of gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme respons...
Categories: Cytochrome P-450 CYP2C9 Inducers, Cytochrome P-450 Enzyme Inducers