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Displaying results 1841 - 1850 of 10000 in total
  1. Drug

    SPG601

    go.drugbank.com/drugs/DB18742
    Investigational

    SPG601 is being investigated for the treatment of fragile X syndrome.

    Synonyms: (R) 3-(5-Dimethylcarbamoyl-pent-1-enyl)-N-(2-hydroxy-1-methylethyl) benzamide
  2. Drug

    Phenytoin

    go.drugbank.com/drugs/DB00252
    ApprovedInvestigationalVet approved

    Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants. … [A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications

    Mixtures: Dilantin W Phenobarbital 15mg, Dilantin W Phenobarbital 30mg CapCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic Index
  3. Drug

    Caffeine

    go.drugbank.com/drugs/DB00201
    ApprovedInvestigational

    [L9863] According to an article from 2017, more than 15 million babies are born prematurely worldwide. This correlates to about 1 in 10 births. … [A187691,L9851] It can be sourced from coffee beans, but also occurs naturally in various teas and cacao beans, which are different than coffee beans.

    Synonyms: 1-methyltheobromine, 3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dionMixtures: GERALGINE-K 500 MG/30 MG/10 MG TABLET, 20 ADET, THOMAPVRIN 250 mg/200 mg/50 mg TABLET, 10 ADET
  4. Drug

    Amuvatinib

    go.drugbank.com/drugs/DB12742
    Investigational

    Amuvatinib is an oral, selective multi-targeted tyrosine kinase inhibitor that suppresses c-MET, c-RET and the mutant forms of c-KIT, PDGFR and FLT3. … Amuvatinib also suppresses Rad51 protein, a critical component of double-stranded DNA repair in cancer cells.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 4-[1]Benzofuro[3,2-D]Pyrimidin-4-Yl-N-(1,3-Benzodioxol-5-Ylmethyl)Piperazine-1-Carbothioamide, 1-Piperazinecarbothioamide, N-(1,3-benzodioxol-5-ylmethyl)-4-benzofuro(3,2-d)pyrimidin-4-yl-
  5. Drug

    Benzydamine

    go.drugbank.com/drugs/DB09084
    ApprovedInvestigational

    Although the indazole analogue benzydamine is a non-steroidal anti-inflammatory drug (NSAID), it has various physicochemical properties and pharmacologic activities that are different from those of traditional … It is used topically for pain relief and anti-inflammatory treatment of the mouth, throat, or muscoskeletal system.

    Mixtures: KLOROBEN FORT 3 MG/ML+ 2 MG/ML ORAL SPREY, 40 ML, TANTUM VERDE DUO FORTE 45 MG+18 MG/15 ML GARGARACategories: Heterocyclic Compounds, 1-Ring, Non COX-2 selective NSAIDS
  6. Drug

    Nitazoxanide

    go.drugbank.com/drugs/DB00507
    ApprovedInvestigationalVet approved

    Nitazoxanide is a first-line, standard treatment for illness caused by C. parvum or G. lamblia infection in healthy (not immunosuppressed) adults and children and may also be considered in the treatment … It is generally well tolerated.

    Categories: Heterocyclic Compounds, 1-RingProducts: NITAZOXANIDA 20 MG / ML POLVO PARA RECONSTITUIR A SUSPENSIÓN ORAL, VIBATRIN® 100 MG / 5 ML
  7. Drug

    Lovastatin

    go.drugbank.com/drugs/DB00227
    ApprovedInvestigational

    [A181087, A181406] Evidence has shown that even for low-risk individuals (with <10% risk of a major vascular event occurring within 5 years) statins cause a 20%-22% relative reduction in major cardiovascular … [A181087, A181406] Lovastatin and other drugs from the statin class of medications including [atorvastatin], [pravastatin], [rosuvastatin], [fluvastatin], and [simvastatin] are considered first-line

    Synonyms: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate, 2β,6α-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactoneCategories: Cytochrome P-450 Substrates, P-glycoprotein inhibitors
  8. Drug

    Dorzolamide

    go.drugbank.com/drugs/DB00869
    ApprovedInvestigational

    [L11377] It works by blocking an enzyme in the ciliary process that regulates ion balance and fluid pressure in the eyes. … Dorzolamide is a non-bacteriostatic sulfonamide derivative [A1304] and topical carbonic anhydrase (CA) inhibitor that treats elevated intraocular pressure (IOP) associated with open-angle glaucoma and

    Mixtures: Cosopt 20 mg/ml + 5 mg/ml Augentropfen, DUOSOPT FREE 20 MG+5 MG/ML GÖZ DAMLASI, ÇÖZELTİ, 60 ADETCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 Substrates
  9. Drug

    Mavacamten

    go.drugbank.com/drugs/DB14921
    ApprovedInvestigational

    It received initial US FDA approval in 2022, and it is one of the first myosin inhibitors to be used in humans. … Mavacamten is a myosin inhibitor indicated for the treatment of adults with symptomatic New York Heart Association (NYHA) class II-III obstructive hypertrophic cardiomyopathy (HCM).

    Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2B6 InducersSynonyms: 6-(((1S)-1-Phenylethyl)amino)-3-(propan-2-yl)-1,2,3,4 tetrahydropyrimidine-2,4-dione
  10. Drug

    4-Nitrophenyl (3S)-3-({N-[(benzyloxy)carbonyl]-L-phenylalanyl}amino)-5-phenyl-1-pentanesulfonate

    go.drugbank.com/drugs/DB02051
    Experimental

    Synonyms: 3-[N-[Benzyloxycarbonyl]-phenylalaninyl-amino]-5-phenyl-pentane-1-sulfonic acid 4-nitro-phenyl ester, 4-Nitrophenyl (3S)-3-({N-[(benzyloxy)carbonyl]-L-phenylalanyl}amino)-5-phenyl-1-pentanesulfonate