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Baloxavir marboxil
go.drugbank.com/drugs/DB13997ApprovedInvestigationalBaloxavir marboxil is an antiviral drug used to treat influenza. More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation. It is a prodrug of baloxavir with an impro...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesTavapadon
go.drugbank.com/drugs/DB14899ApprovedTavapadon is an oral non-ergot dopamine agonist that acts as a selective partial agonist at the dopamine D1 and D5 receptors. It is used to treat Parkinson's disease in adults. The FDA approved tavapadon in September 2026 for the treatme...
Synonyms: PF-06649751Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSodium fluorophosphate
go.drugbank.com/drugs/DB09484ApprovedInvestigationalSodium monofluorophosphate is used in OTC dental preparations to help protect against cavities.
Mixtures: Luster Premium White AM/PM, Nano Silver ToothpasteProducts: Go Smile PM, Finefra SilverSelumetinib
go.drugbank.com/drugs/DB11689ApprovedInvestigationalThe novel MEK 1/2 inhibitor, selumetinib, was initially approved solely for the treatment of pediatric patients with Neurofibromatosis type 1 (NF-1) and symptomatic, inoperable plexiform neurofibromas (PN
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesIdelalisib
go.drugbank.com/drugs/DB09054ApprovedInvestigationalMore specifically, idelalisib targets P110δ, the delta isoform of the enzyme phosphatidylinositol-4,5-bisphosphate 3-kinase, also known as PI-3K. … The PI-3Ks are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesTemozolomide
go.drugbank.com/drugs/DB00853ApprovedInvestigational[A229848, A229858, L32033] Temozolomide is an imidazotetrazine prodrug that is stable at acidic pH but undergoes spontaneous nonenzymatic hydrolysis at neutral or slightly basic pH; these properties allow
Categories: P-glycoprotein substrates, P-glycoprotein substrates with a Narrow Therapeutic IndexHydrocortisone
go.drugbank.com/drugs/DB00741ApprovedInvestigationalVet approvedHydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. It was discovered in the 1930s by Edward Kendall and named Compound F, or 1...
Categories: P-glycoprotein inducers, P-glycoprotein substratesProducts: K & P HYDROCORT 1 % CREME, PS-2896 Hydrocortisone Cream 1%, 0.9gPovidone-iodine
go.drugbank.com/drugs/DB06812ApprovedInvestigationalPovidone-iodine is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It contains from 9.0% to 12.0% available iodine, calculated on a dry basis. This unique complex was discovered in 1955 at the Indu...
Mixtures: P-Care X, P-Care MProducts: Nex Iodio P2, JOD POLYVID WUND U BRA I PPectin
go.drugbank.com/drugs/DB11158ApprovedInvestigationalVet approvedPectin is a heteropolysaccharide commercially derived from the cell wall of higher plants. It is composed of partially methylated polygalacturonic acid units linked in the positions 1-4. The carboxylic group of the constituents of pectin...
Mixtures: LEOLIN-P®, Donnagel-PG LiqDaprodustat
go.drugbank.com/drugs/DB11682ApprovedInvestigationalDaprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that was developed by GSK. Patients with CKD cannot induce erythropoietin (EPO) production in response to hypoxia or anemia. As a potent in...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Inhibitors