Identification
- Brand Names
- Luden's Drops, Sucrets
- Generic Name
- Pectin
- DrugBank Accession Number
- DB11158
- Background
Pectin is a heteropolysaccharide commercially derived from the cell wall of higher plants.2 It is composed of partially methylated polygalacturonic acid units linked in the positions 1-4.7 The carboxylic group of the constituents of pectin can exist in the form of esters, free acids, ammonium, potassium or sodium salts or as acid amides. Under the FDA regulation, pectin qualifies as a GRAS (generally recognized as safe) food substance. This status allows pectin to be used with no limitations.6
- Type
- Biotech
- Groups
- Approved, Investigational, Vet approved
- Synonyms
- Pectin
- External IDs
- E-440
Pharmacology
- Indication
Pectin is used in food as a gelling agent and stabilizer. As a medical drug, it has obtained a great interest in its potential use as a source of dietary fiber, lipid, cholesterol, serum glucose and insulin level lowering effect, gastric emptying delay.2 Some recent studies have researched the possibility of using pectin for the formation of nanoparticles as a delivery vehicle of drugs.3
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- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Pectin increases viscosity and volume of stools which helps it to be used for constipation and diarrhea.5 It is reported as well to present lowering effects of different body components. This effect depends on the type of pectin which indicated that this effect is related to the composition of the correspondent pectin. Nonetheless, this data is still unclear and more studies need to be performed to conclude this effect of pectin.4
- Mechanism of action
Pectin is an adsorbent that binds to bacteria, toxins and other irritants in the intestinal mucosa. Pectin is able to decrease the pH in the intestinal lumen and provides a soothing effect on the irritated mucosa.5
- Absorption
Pectin is not absorbed and it is not distributed in the body.5
- Volume of distribution
Pharmacokinetic studies have not been performed as pectin is not absorbed.
- Protein binding
Pharmacokinetic studies have not been performed as pectin is not absorbed.
- Metabolism
Pectin is depolymerized and de-esterified to a very small extent. It passes to the small intestine as a macromolecule and the majority of the pectin is eliminated unchanged.8
- Route of elimination
Pectin is completely excreted in the feces, including a small amount of trigalacturonic acid that can be found in the colon.5
- Half-life
Pharmacokinetic studies have not been performed as pectin is not absorbed.
- Clearance
Pharmacokinetic studies have not been performed as pectin is not absorbed.
- Adverse Effects
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Pectin is a substance determined to be safe.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Berry Breezer Throat Drop Lozenge 7 mg/1 Oral Topco Associates 2013-03-22 Not applicable US 
Berry Breezer Throat Drops Lozenge 7 mg/1 Oral Dollar General Corporation 2016-03-22 Not applicable US Berry Breezer Throat Drops Lozenge 7 mg/1 Oral CVS Health 2015-05-18 Not applicable US Berry Breezer Throat Relief Drop Lozenge 7 mg/1 Oral Family Dollar 2018-01-25 Not applicable US Berry Soother Throat Drops Lozenge 7 mg/1 Oral Meijer Distribution 2018-07-13 Not applicable US Berry Throat Drop Lozenge 7 mg/1 Oral Walmart 2018-03-15 2022-09-01 US Best Health Berry Soothers Throat Drops Lozenge 7 mg/1 Oral Bestco LLC 2022-04-28 Not applicable US Breezers Cool Berry Lozenge 7 mg/1 Oral Mondelez Global LLC 2019-03-24 Not applicable US Breezers Creamy Strawberry Lozenge 7 mg/1 Oral Mondelez Global LLC 2016-08-03 Not applicable US Breezers Tropical Chill Lozenge 7 mg/1 Oral Mondelez Global LLC 2016-11-21 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image AXCEL KAOPEC SUSPENSION Pectin (20 mg/5ml) + Kaolin (1 g/5ml) Suspension Oral KOTRA PHARMA (M) SDN. BHD. 2020-09-08 Not applicable Malaysia 
AXCEL KAOPEC SUSPENSION Pectin (5 mg/5ml) + Kaolin (1 g/5ml) Suspension Oral KOTRA PHARMA MARKETING 1991-08-19 Not applicable Singapore BEAKOPECTIN SUSPENSION Pectin (130 mg/30ml) + Kaolin (6000 mg/30ml) Suspension Oral BEACONS PHARMACEUTICALS PTE. LTD. 1991-05-23 Not applicable Singapore Benylin DM With Pectin Freezer Pops Pectin (150 mg / unit) + Dextromethorphan hydrobromide (7.5 mg / unit) Liquid Oral Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc Not applicable Not applicable Canada 
Cepacol Sore Throat and Coating Pectin (5 mg/1) + Benzocaine (15 mg/1) Lozenge Oral Reckitt Benckiser 2011-08-04 2014-03-01 US Cepacol Sore Throat Plus Coating Pectin (5 mg/1) + Benzocaine (15 mg/1) Lozenge Oral Combe Incorporated 2006-08-31 2013-12-10 US Diaret Liq Pectin (150 mg / 30 mL) + Kaolin (3.078 g / 30 mL) Liquid Oral Produits Francais Labs Inc. 1981-12-31 1997-05-30 Canada Diaret Tab Pectin (45 mg / tab) + Aluminum hydroxide (70 mg / tab) + Attapulgite (350 mg / tab) + Zinc phenolsulfonate (30 mg / tab) Tablet Oral Produits Francais Labs Inc. 1981-12-31 1997-05-30 Canada Diarex Pectin (300 mg / 30 g) + Kaolin (6.156 g / 30 g) Liquid Oral Pharmavite Laboratories (1987) Inc. 1977-12-31 1999-10-19 Canada Diarex Tab Pectin (45 mg / tab) + Aluminum hydroxide (70 mg / tab) + Attapulgite (350 mg / tab) + Zinc phenolsulfonate (30 mg / tab) Tablet Oral Nutribon (1986) Inc. 1995-12-31 1996-09-30 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Herbon Banana Man Goodypops Pectin (10 mg/1) + Echinacea purpurea (50 mg/1) Lozenge Oral Purity Life Division of SunOpta 2009-09-30 2010-12-31 US Herbon Berry Buddies Pectin (10 mg/1) + Echinacea purpurea (50 mg/1) Lozenge Oral Purity Life Division of SunOpta 2009-09-30 2010-12-31 US Herbon Rockhopper Orange Goodypop Pectin (10 mg/1) + Echinacea purpurea (6.82 mg/1) Lozenge Oral Purity Life Division of SunOpta 2009-09-30 2010-12-31 US Herbon Rockhopper Strawberry Goodypop Pectin (10 mg/1) + Echinacea purpurea (6.82 mg/1) Lozenge Oral Purity Life Division of SunOpta 2009-09-30 2010-12-31 US
Categories
- ATC Codes
- A07BC01 — Pectin
- Drug Categories
- Alimentary Tract and Metabolism
- Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents
- Biological Products
- Biopolymers
- Carbohydrates
- Complex Mixtures
- Compounds used in a research, industrial, or household setting
- Diet, Food, and Nutrition
- Food
- Food Additives
- Food Ingredients
- Intestinal Adsorbents
- Macromolecular Substances
- Physiological Phenomena
- Plant Extracts
- Plant Preparations
- Polymers
- Polysaccharides
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 89NA02M4RX
- CAS number
- 9000-69-5
References
- General References
- Thakur BR, Singh RK, Handa AK: Chemistry and uses of pectin--a review. Crit Rev Food Sci Nutr. 1997 Feb;37(1):47-73. [Article]
- Wikiera A, Irla M, Mika M: [Health-promoting properties of pectin]. Postepy Hig Med Dosw (Online). 2014 Jan 2;68:590-6. doi: 10.5604/17322693.1102342. [Article]
- Verma AK, Kumar A: Pharmacokinetics and biodistribution of negatively charged pectin nanoparticles encapsulating paclitaxel. Cancer Nanotechnol. 2013;4(4-5):99-102. doi: 10.1007/s12645-013-0041-8. Epub 2013 Jun 12. [Article]
- Brouns F, Theuwissen E, Adam A, Bell M, Berger A, Mensink RP: Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women. Eur J Clin Nutr. 2012 May;66(5):591-9. doi: 10.1038/ejcn.2011.208. Epub 2011 Dec 21. [Article]
- Kluwer W. (2008). Clinical pharmacology made incredibly easy (3rd ed.). Lippincott, Williams & Wilkins.
- FDA regulations [Link]
- Dissolutiontech [Link]
- ScienceDirect [Link]
- External Links
- MSDS
- Download (47.3 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Bismuth / Gastric Cancer / Helicobacter Pylori Infection 2 4 Completed Treatment Gastroesophageal Reflux 1 4 Completed Treatment Helicobacter Pylori Infection 2 4 Not Yet Recruiting Treatment Eradication Therapy of Helicobacter Pylori 1 4 Not Yet Recruiting Treatment Helicobacter Pylori Infection 2 4 Recruiting Treatment Helicobacter Pylori Infection 3 4 Unknown Status Treatment Antimicrobial Susceptibility Testing / Helicobacter Pylori Infection 2 4 Unknown Status Treatment Helicobacter Pylori Infection 2 3 Completed Treatment Constipation / Hypomotility 1 3 Withdrawn Prevention Predictable BTP at Swallowing in in Head/Neck Cancer Patients Undergoing Radiotherapy Already Receiving Opioid Therapy for Background Pain 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet Suspension Oral Suspension Suspension Oral 1 g/5ml Suspension Oral 6000 mg/30ml Lozenge Oral 7 mg/1 Lozenge Oral 10.5 mg/1 Lozenge Oral 12 mg/1 Capsule Oral Lozenge Oral Liquid Oral Lozenge Oral 5.4 mg/1 Lozenge Oral 11.5 mg/7g Lozenge Oral 2.8 mg/1 Tablet Oral Paste Oral; Topical Solution Oral Lozenge Oral 2 mg/1 Lozenge Oral 1.7 mg/1 Lozenge Oral 0.1 g/100g Lozenge Oral 3.8 mg/1 Lozenge Oral 5 mg/4.2g Lozenge Oral 10 mg/1 Lozenge Oral 11.5 mg/1 - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Liquid
- Experimental Properties
Property Value Source melting point (°C) 6.1ºC 'MSDS' boiling point (°C) 415.5ºC at 760 mmHg 'MSDS' water solubility Partially soluble in cold water 'MSDS'
Drug created at December 03, 2015 16:51 / Updated at July 13, 2021 09:51