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Sulfamethoxazole
go.drugbank.com/drugs/DB01015ApprovedInvestigational[L11830] It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps … Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria.
Mixtures: SEPTRIN IV 5 ML 10 AMPUL, METOPRIM 200 MG + 40 MG/5 ML SUSPANSIYON, 100 MLCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsUracil mustard
go.drugbank.com/drugs/DB00791ApprovedIt is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 5-[bis(2-chloroethyl)amino]-2,4(1H,3H)-pyrimidinedione, 5-(di-2-chloroethyl)aminouracilIrinotecan
go.drugbank.com/drugs/DB00762ApprovedInvestigationalIrinotecan is a topoisomerase inhibitor used for chemotherapy. It is a water-soluble analogue of [camptothecin], which is extracted from the Chinese tree _Camptotheca acuminate_. … [L50186] The active metabolite SN-38 is also a potent inhibitor of DNA topoisomerase I.
Categories: Topoisomerase 1 (TOP1) inhibitors, P-glycoprotein substrates with a Narrow Therapeutic IndexSynonyms: (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 4-(2-(5-(3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)-1H-indol-1-yl, )ethyl)piperidine-1-carboxylateErgotamine
go.drugbank.com/drugs/DB00696ApprovedA vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders.
Mixtures: CAFERGOT 1 MG/100 MG TABLET, 30 ADET, ERGOTAMINA 1 MG + CAFEINA 100 MG TABLETASCategories: Adrenergic alpha-1 Receptor Antagonists, Serotonin 5-HT1 Receptor AgonistsMethopterin
go.drugbank.com/drugs/DB16620InvestigationalMethopterin is thought to have effects on osteoclasts and to inhibit inflammatory bone destruction.
Synonyms: 10-methylfolic acid, 10-methylpteroylglutamic acidTrifluridine
go.drugbank.com/drugs/DB00432ApprovedInvestigationalIt displays effective antiviral activity against Herpes simplex virus type 1 and 2 [A35271]. … Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine] [A35271].
Mixtures: LONSURF FILM-COATED TABLET 15 MG/6.14 MG, LONSURF FILM-COATED TABLET 15 MG/6.14 MGCategories: Heterocyclic Compounds, 1-RingSecnidazole
go.drugbank.com/drugs/DB12834ApprovedInvestigationalSecnidazole is a second-generation 5-nitroimidazole antimicrobial agent. … It is structurally related to other 5-nitroimidazoles, including [DB00916] and [DB00911], but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class
Mixtures: ITRACONAZOL 33.3 MG + SECNIDAZOL 166.66 MG CÁPSULA, FLUCONAZOL+SECNIDAZOL 75MG/1000 MGCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesRizatriptan
go.drugbank.com/drugs/DB00953ApprovedInvestigationalRizatriptan is a second-generation triptan [A258918] and a selective 5-HT<sub>1B and 5-HT1D</sub> receptor agonist.
Categories: Serotonin 5-HT1 Receptor Agonists, Selective Serotonin 5-HT1 Receptor AgonistsSynonyms: N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine, N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]-ethanamineSulfasalazine
go.drugbank.com/drugs/DB00795ApprovedInvestigationalIt is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA). … [A255592] Meta-analysis of 19 randomized controlled trials indicated that sulfasalazine is superior to placebo in inducing remission; however, with no supported evidence of mucosal healing, sulfasalazine
Categories: Non COX-2 selective NSAIDSSynonyms: 5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid, 5-((p-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid