Methopterin

DB16620InvestigationalSmall molecule

Methopterin is thought to have effects on osteoclasts and to inhibit inflammatory bone destruction.

Mechanism: Methopterin has been shown to inhibit the proliferation, activation, and bone resorption action of osteoclasts, and induce the apoptosis of osteoclasts, likely contributing to the ability of methopterin to inhibit inflammatory bone destruction.
Curator reviewed · 1 reference
Formula / weight: C₂₀H₂₁N₇O₆ · 455.431 g/mol (avg)
Also known as: 10-methylfolic acid · 10-methylpteroylglutamic acid · Methopterine · Methotrexate related compound C · N10-methylfolic acid
Code names: NSC-107144

Resolves to

Compound

Structure

InChIKeyHLIXOCXUWGDBNP-ZDUSSCGKSA-NSMILESCN(CC1=CN=C2N=C(N)NC(=O)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

Targets

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

12Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Methopterin, and which of those have an active Phase 3 trial?

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