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Nilvadipine
go.drugbank.com/drugs/DB06712ApprovedNilvadipine is a calcium channel blocker (CCB) for the treatment of hypertension.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: Tensan retard 8 mg - KapselnPotassium Iodide
go.drugbank.com/drugs/DB06715ApprovedInvestigationalSaturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperthyroidism (also known as thyroid storm or thyrotoxic crisis). SSKI can also be used for radi...
Mixtures: I D M Expectorant Tab, One A Day Multiple Vit W MineralsProducts: Theraplex F Tab 0.12mg, YODOFAM JARABE X 120 MLVelaglucerase alfa
go.drugbank.com/drugs/DB06720ApprovedVelaglucerase alfa is a gene-activated human recombinant glucocerebrosidase used for the treatment of Type 1 Gaucher disease, caused by a deficiency of the lysosomal enzyme glucocerebrosidase. … Additionally, Velaglucerase alfa has also been investigated for use in Type 3 Gaucher disease.
Products: VPRIV ®, VPRIV 400 ÜNİTE İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN TOZ, 5 ADETSparteine
go.drugbank.com/drugs/DB06727ApprovedWithdrawnIt is a sodium channel blocker, so it falls in the category of class 1a antiarrhythmic agents. … Sparteine is a plant alkaloid derived from _Cytisus scoparius_ and _Lupinus mutabilis_ which may chelate calcium and magnesium.
Categories: Antiarrhythmics, Class I, Cytochrome P-450 SubstratesAniline
go.drugbank.com/drugs/DB06728InvestigationalConsisting of an amine attached to a benzene ring, aniline is the prototypical aromatic amine. … Aniline is colorless, but it slowly oxidizes and resinifies in air, giving a red-brown tint to aged samples.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 SubstratesSynonyms: Fentanyl impurity F, Trimethoprim specified impurity KGestodene
go.drugbank.com/drugs/DB06730InvestigationalGestodene is a progestogen hormonal contraceptive.
Mixtures: FEMIANE®, FEMIANE®Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inhibitorsbeta-Naphthoflavone
go.drugbank.com/drugs/DB06732ExperimentalIt may be a chemopreventive agent. … β-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and induces cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs).
Categories: Cytochrome P-450 CYP1A2 Inducers, Heterocyclic Compounds, 1-RingSynonyms: 3-phenyl-1H-naphtho(2,1-b)pyran-1-one, β-NFBafilomycin A1
go.drugbank.com/drugs/DB06733ExperimentalBafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase). The most commonly utilized bafilomycin is bafilomycin A1. … The bafilomycins refer to a category of toxic macrolide antibiotics that are derivatives of Streptomyces griseus.
Zaltoprofen
go.drugbank.com/drugs/DB06737InvestigationalA non-steroidal anti-inflammatory drug approved for use in Japan in 1993.
Categories: Cytochrome P-450 Substrates, Non COX-2 selective NSAIDSBW-A 58C
go.drugbank.com/drugs/DB06740ExperimentalBW-A 58C, also known as 2-(4-tert-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone, is an experimental naphthoquinone antimalarial drug which undergoes extensive alkyl hydroxylation to a single t-butylhydroxy … metabolite in man in vivo and also in human liver microsomes, where this is catalysed primarily by a 54 kDa CYP2C9 form of cytochrome P450, P450hB20-27.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 InhibitorsSynonyms: 2-(4'-t-Butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone, 2-(4-tert-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone