Potassium Iodide
Identification
- Name
- Potassium Iodide
- Accession Number
- DB06715
- Description
Saturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperthyroidism (also known as thyroid storm or thyrotoxic crisis). SSKI can also be used for radioiodine-contamination emergencies or in preparation of thyrotoxic patients for thyroidectomy.
- Type
- Small Molecule
- Groups
- Approved
- Structure
- Weight
- Average: 166.0028
Monoisotopic: 165.868175281 - Chemical Formula
- IK
- Synonyms
- Kaliumiodid
- KI
- Potasio ioduro
- Potassium iodide
- External IDs
- NSC-77362
Pharmacology
- Indication
Potassium Iodide is oral antithyroid agent used in the prevention of radioactive iodine uptake into the thyroid gland during a nuclear radiation emergency. Potassium Iodide may be used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution.
- Associated Conditions
- Associated Therapies
- Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More- Pharmacodynamics
It works in the thyroid gland. By inhibiting thyroid hormone synthesis and release, thyroid gland vascularity is reduced, thyroid gland tissue becomes firmer, thyroid cell size is reduced, follicular colloid reaccumulates, and bound iodine levels increase. As a protectant following radiation exposure, KI blocks the uptake of radioactive iodine isotopes by the thyroid gland thereby minimizing the risk of radiation-induced thyroid neoplasms.
- Mechanism of action
Target Actions Organism UTyrosine binderHumans - Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half-life
- Not Available
- Clearance
- Not Available
- Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More- Toxicity
- Not Available
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Unlock Additional DataAbciximab Potassium Iodide may increase the anticoagulant activities of Abciximab. Acalabrutinib The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Acalabrutinib. Acebutolol The risk or severity of adverse effects can be increased when Potassium Iodide is combined with Acebutolol. Aceclofenac Potassium Iodide may increase the hyperkalemic activities of Aceclofenac. Acemetacin Potassium Iodide may increase the hyperkalemic activities of Acemetacin. Acenocoumarol Potassium Iodide may increase the anticoagulant activities of Acenocoumarol. Acetohexamide The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Potassium Iodide. Acetyldigitoxin The serum concentration of Acetyldigitoxin can be increased when it is combined with Potassium Iodide. Acetylsalicylic acid Potassium Iodide may increase the anticoagulant activities of Acetylsalicylic acid. Afatinib The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Afatinib. Additional Data Available- Extended DescriptionExtended DescriptionAvailable for Purchase
Extended description of the mechanism of action and particular properties of each drug interaction.
Learn more - SeveritySeverityAvailable for Purchase
A severity rating for each drug interaction, from minor to major.
Learn more - Evidence LevelEvidence LevelAvailable for Purchase
A rating for the strength of the evidence supporting each drug interaction.
Learn more - ActionActionAvailable for Purchase
An effect category for each drug interaction. Know how this interaction affects the subject drug.
Learn more
- Food Interactions
- No interactions found.
Products
- Active Moieties
Name Kind UNII CAS InChI Key Potassium cation ionic 295O53K152 24203-36-9 NPYPAHLBTDXSSS-UHFFFAOYSA-N Iodide ionic 09G4I6V86Q 20461-54-5 XMBWDFGMSWQBCA-UHFFFAOYSA-M - Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Unlock Additional DataSski Solution 1 g/1mL Oral Upsher-Smith Laboratories, LLC 1973-04-30 2019-06-30 US Sski Solution 1 g/1mL Oral Avondale Pharmaceuticals, Llc 2017-11-13 Not applicable US ThyroSafe Tablet 65 mg Oral Recip Ab 2003-11-04 2008-07-07 Canada Additional Data Available- Application NumberApplication NumberAvailable for Purchase
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
Learn more - Product CodeProduct CodeAvailable for Purchase
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
Learn more
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Unlock Additional DataIodine Capsule 0.22 mg Oral Thorne Research Inc. 1997-09-09 2006-08-04 Canada Iodine Ctr Srt 300mg Tablet, extended release Oral Bioenergy Inc. 1979-12-31 1998-06-03 Canada Iodine Tab 0.5mg Tablet Oral Creative Nutrition Canada Corp. 1986-12-31 1998-07-16 Canada Iosat Tablet 65 mg/1 Oral Anbex Inc. 2013-05-01 Not applicable US Iosat Tablet 130 mg/1 Oral Anbex Inc. 1982-10-14 Not applicable US Potassium Iodide Solution 65 mg/1mL Oral Mission Pharmacal Company 2016-05-15 Not applicable US Radiban Tablet 130 mg/1 Oral United Douglas Pharm., Inc. 2011-12-20 Not applicable US Theraplex F Tab 0.12mg Tablet Oral Therapeutic Foods Co. 1989-12-31 2009-07-24 Canada Thyroblock Tab 130mg Tablet Oral Carter Horner Corp. 1981-12-31 2003-03-14 Canada ThyroSafe Tablet 65 mg/1 Oral Recipharm Ab (Publ) 2002-09-30 Not applicable US Additional Data Available- Application NumberApplication NumberAvailable for Purchase
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
Learn more - Product CodeProduct CodeAvailable for Purchase
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
Learn more
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 24 Multivitamins + Minerals Potassium Iodide (.1 mg) + Ascorbic acid (150 mg) + Beta carotene (10000 unit) + Biotin (25 mcg) + Calcium (130 mg) + Cholecalciferol (400 unit) + Choline bitartrate (25 mg) + Chromium (20 mcg) + Copper (1 mg) + Cyanocobalamin (25 mcg) + Ferrous fumarate (15 mg) + Folic acid (.8 mg) + Inositol (25 mg) + Magnesium (65 mg) + Manganese (2 mg) + Molybdenum (20 mcg) + Niacin (25 mg) + Calcium pantothenate (25 mg) + Potassium (15 mg) + Pyridoxine hydrochloride (25 mg) + Racemethionine (25 mg) + Riboflavin (25 mg) + Selenium (20 mcg) + Thiamine hydrochloride (25 mg) + Vanadium (20 mcg) + Vitamin A palmitate (5000 unit) + Vitamin E (50 unit) + Zinc (10 mg) Tablet Oral Stanley Pharmaceuticals, A Division Of Vita Health Products Inc. 1997-04-30 2002-07-31 Canada 50 Plus Multiple Vitamins & Minerals Potassium Iodide (0.15 mg) + Ascorbic acid (90 mg) + Biotin (45 mcg) + Calcium (200 mg) + Cholecalciferol (400 unit) + Chromium (10 mcg) + Copper (2 mg) + Cyanocobalamin (25 mcg) + Folic acid (0.4 mg) + Magnesium (100 mg) + Manganese (5 mg) + Molybdenum (25 mcg) + Nicotinamide (40 mg) + Pantothenic acid (10 mg) + Pyridoxine hydrochloride (3 mg) + Riboflavin (3.2 mg) + Selenium (25 mcg) + Thiamine mononitrate (2.25 mg) + Vanadium (10 mcg) + Vitamin A palmitate (6000 unit) + Zinc (15 mg) Tablet Oral Gfr Pharma Ltd. 2002-10-20 2004-06-15 Canada Addnutriv Potassium Iodide (130 mcg) + Chromic chloride (10 mcg) + Cupric Chloride (380 mcg) + Ferric chloride (1100 mcg) + Manganese (55 mcg) + Sodium selenite (79 mcg) + Sodium fluoride (950 mcg) + Sodium molybdate (19 mcg) + Zinc (5000 mcg) Solution Intravenous Fresenius Kabi Not applicable Not applicable Canada Avon Vitadvance Multi-kids Complete Potassium Iodide (.075 mg) + Ascorbic acid (100 mg) + Beta carotene (2500 unit) + Biotin (60 mcg) + Calcium (125 mg) + Cholecalciferol (400 unit) + Cupric oxide (1 mg) + Cyanocobalamin (6 mcg) + Ferrous fumarate (4 mg) + Folic acid (.4 mg) + Nicotinamide (20 mg) + Calcium pantothenate (10 mg) + Pyridoxine hydrochloride (2 mg) + Riboflavin (1.7 mg) + Thiamine mononitrate (1.5 mg) + Vitamin A palmitate (2500 unit) + alpha-Tocopherol succinate (20 unit) Tablet Oral Avon Products, Inc. 1994-12-31 2005-07-29 Canada Bear Essentials Potassium Iodide (0.0304 mg) + Ascorbic acid (12 mg) + Cholecalciferol (80 unit) + Cyanocobalamin (1.2 mcg) + Folic acid (0.080 mg) + Pantothenic acid (2 mg) + Vitamin A (1000 unit) + Vitamin E (6 unit) Tablet Oral Health Asure, Inc. 2003-07-02 2008-06-24 Canada Body Rox Potassium Iodide (0.05 mg) + Beta carotene (3000.0 unit) + Biotin (100.0 mcg) + Calcium (75.0 mg) + Calcium ascorbate (167.0 mg) + Cholecalciferol (133.0 unit) + Choline bitartrate (15.0 mg) + Chromium (50.0 mcg) + Copper (0.33 mg) + Cyanocobalamin (20.0 mcg) + Folic acid (0.267 mg) + Inositol (10.0 mg) + Magnesium (37.5 mg) + Manganese (1.0 mg) + Molybdenum (15.0 mcg) + Niacin (1.66 mg) + Nicotinamide (3.3 mg) + Calcium pantothenate (10.0 mg) + Pyridoxine hydrochloride (3.0 mg) + Riboflavin (3.0 mg) + Selenium (40.0 mcg) + Silicon (1.0 mg) + Thiamine hydrochloride (3.0 mg) + Vanadium (10.0 mcg) + Zinc (4.0 mg) + alpha-Tocopherol succinate (66.7 unit) Tablet Oral Usana Health Sciences, Inc. 2003-09-02 2008-06-27 Canada C. Vit-min Formula Potassium Iodide (0.15 mg) + Ascorbic acid (100 mg) + Biotin (30 mcg) + Calcium (175 mg) + Cholecalciferol (400 unit) + Choline (30 mg) + Chromium (50 mcg) + Copper (5 mg) + Cyanocobalamin (100 mcg) + Ferrous fumarate (10 mg) + Folic acid (0.600 mg) + Inositol (30 mg) + Magnesium (80 mg) + Manganese (5 mg) + Molybdenum (25 mcg) + Nicotinamide (50 mg) + Calcium pantothenate (50 mg) + Potassium (40 mg) + Pyridoxine hydrochloride (50 mg) + Racemethionine (3 mg) + Riboflavin (50 mg) + Sodium selenite (200 mcg) + Silicon (0.01 mg) + Thiamine (50 mg) + Vanadium (10 mcg) + Vitamin A (5000 unit) + Zinc (40 mg) + alpha-Tocopherol acetate (100 unit) Tablet Oral Nutramed Laboratories Inc. Not applicable Not applicable Canada Central-vite 18 Essential Potassium Iodide (0.15 mg) + Ascorbic acid (90 mg) + Beta carotene (3000 unit) + Biotin (45 mcg) + Calcium (175 mg) + Calcium Phosphate (125 mg) + Cholecalciferol (400 unit) + Cupric oxide (2 mg) + Cyanocobalamin (9 mcg) + Ferrous fumarate (10 mg) + Folic acid (0.4 mg) + Magnesium (100 mg) + Nicotinamide (40 mg) + Calcium pantothenate (10 mg) + Pyridoxine hydrochloride (3 mg) + Riboflavin (3.2 mg) + Thiamine mononitrate (2.25 mg) + Vitamin A (2000 unit) + alpha-Tocopherol acetate (25 unit) Tablet Oral Vita Health Products Inc 1998-04-24 2002-07-31 Canada Century Complete Potassium Iodide (.15 mg) + Ascorbic acid (90 mg) + Beta carotene (3000 unit) + Biotin (45 mcg) + Calcium (175 mg) + Calcium Phosphate (125 mg) + Cupric oxide (2 mg) + Cyanocobalamin (9 mcg) + Ferrous fumarate (10 mg) + Folic acid (.4 mg) + Magnesium (100 mg) + Nicotinamide (40 mg) + Calcium pantothenate (10 mg) + Pyridoxine hydrochloride (3 mg) + Riboflavin (3.2 mg) + Thiamine mononitrate (2.25 mg) + Vitamin A (2000 unit) + Vitamin D (400 unit) + alpha-Tocopherol acetate (25 unit) Tablet Oral Vita Health Products Inc 1998-03-17 2002-07-31 Canada Chela Potassium Plus Potassium Iodide (.1 mg) + Folic acid (.4 mg) + Nicotinamide (10 mg) + Potassium (99 mg) + Riboflavin (2 mg) + Thiamine hydrochloride (2 mg) Tablet Oral Nu Life Nutrition Ltd. 1988-12-31 2000-03-03 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Addamel N Potassium Iodide (0.013 mg/1mL) + Chromic chloride hexahydrate (1 ug/1mL) + Cuprous chloride (0.13 mg/1mL) + Ferric chloride (0.11 mg/1mL) + Manganese chloride tetrahydrate (0.027 mg/1mL) + Sodium selenite (3.2 ug/1mL) + Sodium fluoride (0.095 mg/1mL) + Sodium molybdate dihydrate (1.9 ug/1mL) + Zinc chloride (0.65 mg/1mL) Injection, solution Intravenous Fresenius Kabi USA, LLC 2013-05-07 2017-03-31 US BumP DHA Potassium Iodide (250 ug/1) + Cobamamide (500 mg/1) + Flavin adenine dinucleotide (1 mg/1) + Flavin mononucleotide (2 mg/1) + Iron (15 mg/1) + Leucovorin (1 mg/1) + Levomefolate magnesium (1 mg/1) + Magnesium oxide (125 mg/1) + NADH (25 ug/1) + Omega-3 fatty acids (300 mg/1) + Pyridoxal phosphate (5 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Zinc glycinate (15 1/1) Capsule Oral Centurion Labs 2017-03-24 2017-04-17 US Cavan Heme OB Potassium Iodide (175 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Iron (28 mg/1) + Niacin (17 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Sodium selenate (65 ug/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (15 mg/1) + alpha-Tocopherol succinate (10 [iU]/1) Tablet Oral Seton Pharmaceuticals 2010-08-03 2012-06-10 US Cavan Prenatal Potassium Iodide (150 ug/1) + Ascorbic acid (120 mg/1) + Calcium carbonate (200 mg/1) + Cholecalciferol (420 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (8 ug/1) + Ferrous fumarate (28 mg/1) + Folic acid (1 mg/1) + Niacin (20 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Thiamine mononitrate (3 mg/1) + Vitamin E (30 [iU]/1) + Zinc oxide (15 ug/1) Tablet Oral Seton Pharmaceuticals 2009-07-09 2009-07-22 US CitraNatal 90 DHA Potassium Iodide (150 ug/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (159 mg/1) + Cupric oxide (2 mg/1) + Docusate sodium (50 mg/1) + Ferrous gluconate dihydrate (5 mg/1) + Folic acid (1 mg/1) + Iron (85 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Thiamine mononitrate (4.54 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1) Tablet Oral Mission Pharmacal Company 2014-04-11 Not applicable US CitraNatal DHA Potassium Iodide (150 mg/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (125 mg/1) + Cupric oxide (2 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Iron (27 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1) Tablet Oral Mission Pharmacal 2007-11-20 Not applicable US CitraNatal DHA Potassium Iodide (150 mg/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (124 mg/1) + Cupric oxide (2 mg/1) + Doconexent (250 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Icosapent (0.625 mg/1) + Iron (27 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1) Kit Oral Mission Pharmacal Company 2014-05-22 Not applicable US CitraNatal Rx Potassium Iodide (150 mg/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (124 mg/1) + Cupric oxide (2 mg/1) + Folic acid (1 mg/1) + Iron (27 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1) Tablet Oral Mission Pharmacal 2014-08-11 Not applicable US CitraNatal Rx Potassium Iodide (150 mg/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (125 mg/1) + Cupric oxide (2 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Iron (27 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1) Tablet Oral Mission Pharmacal 2007-11-26 Not applicable US Foltabs Prenatal Potassium Iodide (150 ug/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (125 mg/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (2 mg/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Docusate sodium (50 mg/1) + Ferrous gluconate dihydrate (13 mg/1) + Folic acid (1 mg/1) + Iron (14 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Riboflavin (3.4 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (25 mg/1) Tablet Oral Mayne Pharma 2009-01-01 2016-12-31 US
Categories
- ATC Codes
- S01XA04 — Potassium iodide
- S01XA — Other ophthalmologicals
- S01X — OTHER OPHTHALMOLOGICALS
- S01 — OPHTHALMOLOGICALS
- S — SENSORY ORGANS
- V03AB — Antidotes
- V03A — ALL OTHER THERAPEUTIC PRODUCTS
- V03 — ALL OTHER THERAPEUTIC PRODUCTS
- V — VARIOUS
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as alkali metal iodides. These are inorganic compounds in which the largest halogen atom is Iodine, and the heaviest metal atom is an alkali metal.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Alkali metal salts
- Sub Class
- Alkali metal iodides
- Direct Parent
- Alkali metal iodides
- Alternative Parents
- Inorganic salts
- Substituents
- Alkali metal iodide / Inorganic salt
- Molecular Framework
- Not Available
- External Descriptors
- potassium salt (CHEBI:8346)
Chemical Identifiers
- UNII
- 1C4QK22F9J
- CAS number
- 7681-11-0
- InChI Key
- NLKNQRATVPKPDG-UHFFFAOYSA-M
- InChI
- InChI=1S/HI.K/h1H;/q;+1/p-1
- IUPAC Name
- potassium iodide
- SMILES
- [K+].[I-]
References
- Synthesis Reference
Stanley D. Lazarus, "Production of thermally stabilized polyester with alkylene carbonates and sodium or potassium iodide." U.S. Patent US4327207, issued October, 1973.
US4327207- General References
- Not Available
- External Links
- KEGG Drug
- D01016
- KEGG Compound
- C08219
- PubChem Compound
- 4875
- PubChem Substance
- 99443267
- ChemSpider
- 4709
- 8597
- ChEBI
- 8346
- ChEMBL
- CHEMBL1141
- PharmGKB
- PA451060
- Wikipedia
- Potassium_iodide
- AHFS Codes
- 68:36.08 — Antithyroid Agents
- 48:16.00 — Expectorants
- 88:29.00* — Minerals
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Diabetic Macular Edema (DME) 1 4 Completed Treatment Graves Diseases / Hyperthyroidism 1 4 Completed Treatment Hyperemesis Gravidarum / Morning Sickness / Nausea / Pregnant State / Vomiting 1 4 Completed Treatment Pain 1 4 Completed Treatment Pregnant State 1 4 Not Yet Recruiting Treatment Dental Caries in Children 1 4 Recruiting Treatment Hyperthyroidism, Autoimmune 1 3 Recruiting Other Graves Diseases 1 3 Terminated Prevention Heart Failure 1 3 Terminated Treatment Pregnant State 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection, solution, concentrate Intravenous 5.33 mcg/ml Injection, solution, concentrate Intravenous 6.9 mcg/mL Injection, solution Intravenous 53.3 mcg/10mL Injection, solution Intravenous drip 166 mcg/10ml Injection, solution, concentrate Intravenous 17.3 μg/ml Injection, solution, concentrate Intravenous 4.381 μg/ml Solution Intravenous Solution Topical 73 mL Tablet, chewable Oral Bar, chewable Oral Capsule Oral 2 mcg Capsule Oral 50 mcg Capsule Oral 400 mcg Capsule Oral Solution / drops Ophthalmic 5 MG/ML Tablet, extended release Oral Tablet, film coated 8000 IU Tablet Oral 100 mcg/1 Tablet Oral 112 mcg/1 Tablet Oral 125 mcg/1 Tablet Oral 150 mcg/1 Tablet Oral 50 mcg/1 Tablet Oral 75 mcg/1 Tablet Oral 88 mcg/1 Solution Intravenous 1.66 g/L Syrup 150 mg/5ml Tablet, coated Oral 20 mg Liquid Oral Liquid Topical Tablet, coated Oral Capsule Oral 0.22 mg Solution Topical Tablet, extended release Oral Tincture Topical Solution Oral 2 % Solution Topical 7 % Tablet Oral 65 mg/1 Syrup Oral 0.1 g Tablet Oral 0.131 mg Tablet Oral 0.196 mg Tablet Oral 0.262 mg Tablet Oral 2 mg Tablet Oral 100 µg Tablet Oral 200 mcg Tablet Oral 0.1 mg Tablet Oral 65 mg Tablet, effervescent Oral Tablet Oral 0.112 mg Tablet Oral 0.125 mg Tablet Oral 0.15 mg Tablet Oral 0.05 mg Tablet Oral 0.075 mg Tablet Oral 0.088 mg Tablet Oral 0.097 mg Tablet Oral 0.122 mg Tablet Oral 0.146 mg Tablet Oral 0.049 mg Tablet Oral 0.073 mg Liquid Intravenous Syrup Oral Solution Topical 2 g Tablet, coated Oral 75 mg Solution, concentrate Intravenous 53.3 mcg Tablet, chewable Oral 200 mcg Injection, solution, concentrate Intravenous 44.569 mg Tablet Oral 150 mg Solution / drops Ophthalmic 0.3 % Injection, solution Intravenous Injection, solution, concentrate Intravenous; Parenteral 20 ug/1mL Injection, solution, concentrate Parenteral 521 mcg/ml Solution Intravenous 36 μg/10ml Powder Not applicable 1 kg/1kg Solution Oral 2 g/100mL Tablet, coated Oral 50 mg Capsule, gelatin coated Oral Pill Oral Tablet Oral 130 mg/1 Tablet Oral Kit Oral Solution Oral 60 g/100mL Solution, concentrate Oral 100 g/100mL Powder Topical Solution, concentrate Intravenous 30.45 mcg Solution Oral 1 g/1mL Solution Oral 100 g/100mL Solution / drops Oral Injection, solution, concentrate Intravenous 69700 mcg/10ml Tablet Oral Tablet Oral 100 mcg Tablet Oral 125 mcg Tablet Oral 150 mcg Tablet Oral 50 mcg Tablet Oral 75 mcg Solution Oral 65 mg/1mL Injection, solution Intravenous 5.324 mg Injection, solution, concentrate Intravenous 695.8 mcg/ml Injection, solution, concentrate Intravenous 697 mcg/ml Tablet, coated Oral 185 mg Tablet, chewable Oral 5000 IU Tablet, film coated Oral Capsule 75 mg Capsule, liquid filled Oral Capsule, gelatin coated Oral 0.5 mg Solution / drops Ophthalmic 5 mg Powder Oral Solution Oral 1.5 g - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 0.2 ChemAxon Physiological Charge 1 ChemAxon Hydrogen Acceptor Count 0 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 0 Å2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 0 m3·mol-1 ChemAxon Polarizability 1.78 Å3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule Yes ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.7647 Blood Brain Barrier + 0.9702 Caco-2 permeable + 0.6625 P-glycoprotein substrate Non-substrate 0.8989 P-glycoprotein inhibitor I Non-inhibitor 0.984 P-glycoprotein inhibitor II Non-inhibitor 0.9854 Renal organic cation transporter Non-inhibitor 0.9282 CYP450 2C9 substrate Non-substrate 0.8261 CYP450 2D6 substrate Non-substrate 0.7789 CYP450 3A4 substrate Non-substrate 0.7857 CYP450 1A2 substrate Non-inhibitor 0.7164 CYP450 2C9 inhibitor Non-inhibitor 0.8527 CYP450 2D6 inhibitor Non-inhibitor 0.9142 CYP450 2C19 inhibitor Non-inhibitor 0.8842 CYP450 3A4 inhibitor Non-inhibitor 0.9317 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9022 Ames test Non AMES toxic 0.6838 Carcinogenicity Carcinogens 0.659 Biodegradation Not ready biodegradable 0.5913 Rat acute toxicity 2.9202 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9535 hERG inhibition (predictor II) Non-inhibitor 0.9657
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Targets
References
- Pisarev MA, Aiello LO: Studies on the mechanism of action of potassium iodide on thyroid protein biosynthesis. Acta Endocrinol (Copenh). 1976 Jun;82(2):298-305. [PubMed:946922]
- Foldes J, Gesztesi E, Juhasz J: Mechanism of action of di-iodotyrosine and of iodine. Acta Med Acad Sci Hung. 1974;31(1-2):131-7. [PubMed:4464746]
Drug created on May 16, 2010 17:39 / Updated on January 25, 2021 22:38