Potassium Iodide

Identification

Summary

Potassium Iodide is an oral antithyroid agent used for the prevention of radioactive iodine uptake into the thyroid gland during a nuclear radiation emergency.

Brand Names

Iosat, Pregvit, Thyrosafe, Thyroshield, Xylocaine With Epinephrine

Generic Name

Potassium Iodide

DrugBank Accession Number

DB06715

Background

Saturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperthyroidism (also known as thyroid storm or thyrotoxic crisis). SSKI can also be used for radioiodine-contamination emergencies or in preparation of thyrotoxic patients for thyroidectomy.

Type

Small Molecule

Groups

Approved

Structure

Download

MOLSDFPDBSMILESInChI

Similar Structures

Structure for Potassium Iodide (DB06715)

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Weight

Average: 166.0028
Monoisotopic: 165.868175281

Chemical Formula

IK

Synonyms

• Kaliumiodid
• KI
• Potasio ioduro
• Potassium Iodide

External IDs

• NSC-77362

Pharmacology

Indication

Potassium Iodide is oral antithyroid agent used in the prevention of radioactive iodine uptake into the thyroid gland during a nuclear radiation emergency. Potassium Iodide may be used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution.

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Associated Conditions

• Acute radiation sickness
• Folate deficiency
• Goitre
• Hypothyroidism
• Iodine Deficiency
• Iron Deficiency (ID)
• Thyroid Cancers

Associated Therapies

• Nutritional supplementation
• Skin disinfection
• Oral disinfection

Contraindications & Blackbox Warnings

Contraindications & Blackbox Warnings

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Pharmacodynamics

It works in the thyroid gland. By inhibiting thyroid hormone synthesis and release, thyroid gland vascularity is reduced, thyroid gland tissue becomes firmer, thyroid cell size is reduced, follicular colloid reaccumulates, and bound iodine levels increase. As a protectant following radiation exposure, KI blocks the uptake of radioactive iodine isotopes by the thyroid gland thereby minimizing the risk of radiation-induced thyroid neoplasms.

Mechanism of action

Target	Actions	Organism
UTyrosine	binder	Humans

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drug	Interaction
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Abciximab	Potassium Iodide may increase the anticoagulant activities of Abciximab.
Acalabrutinib	The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Acalabrutinib.
Acebutolol	The risk or severity of adverse effects can be increased when Potassium Iodide is combined with Acebutolol.
Aceclofenac	Potassium Iodide may increase the hyperkalemic activities of Aceclofenac.
Acemetacin	Potassium Iodide may increase the hyperkalemic activities of Acemetacin.
Acenocoumarol	Potassium Iodide may increase the anticoagulant activities of Acenocoumarol.
Acetohexamide	The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Potassium Iodide.
Acetyldigitoxin	The serum concentration of Acetyldigitoxin can be increased when it is combined with Potassium Iodide.
Acetylsalicylic acid	Potassium Iodide may increase the hyperkalemic activities of Acetylsalicylic acid.
Afatinib	The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Afatinib.

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Food Interactions

No interactions found.

Products

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Active Moieties

Name	Kind	UNII	CAS	InChI Key
Potassium cation	ionic	295O53K152	24203-36-9	NPYPAHLBTDXSSS-UHFFFAOYSA-N
Iodide	ionic	09G4I6V86Q	20461-54-5	XMBWDFGMSWQBCA-UHFFFAOYSA-M

Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Sski	Solution	1 g/1mL	Oral	Atlantic Biologicals Corp.	2017-11-13	Not applicable
Sski	Solution	1 g/1mL	Oral	Upsher-Smith Laboratories, LLC	1973-04-30	2019-06-30
Sski	Solution	1 g/1mL	Oral	Avondale Pharmaceuticals, Llc	2017-11-13	Not applicable
ThyroSafe	Tablet	65 mg	Oral	Recip Ab	2003-11-04	2008-07-07

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Iodine	Capsule	0.22 mg	Oral	Thorne Research Inc.	1997-09-09	2006-08-04
Iodine Ctr Srt 300mg	Tablet, extended release	300 mcg / tab	Oral	Bioenergy Inc.	1979-12-31	1998-06-03
Iodine Tab 0.5mg	Tablet	.5 mg / tab	Oral	Creative Nutrition Canada Corp.	1986-12-31	1998-07-16
Iosat	Tablet	130 mg/1	Oral	Anbex Inc.	1982-10-14	Not applicable
Iosat	Tablet	65 mg/1	Oral	Anbex Inc.	2013-05-01	Not applicable
Potassium Iodide	Solution	65 mg/1mL	Oral	Mission Pharmacal Company	2016-05-15	Not applicable
Radiban	Tablet	130 mg/1	Oral	United Douglas Pharm., Inc.	2011-12-20	Not applicable
Theraplex F Tab 0.12mg	Tablet	0.09 mg	Oral	Therapeutic Foods Co.	1989-12-31	2009-07-24
Thyroblock Tab 130mg	Tablet	130 mg	Oral	Carter Horner Corp.	1981-12-31	2003-03-14
ThyroSafe	Tablet	65 mg/1	Oral	Recipharm Ab (Publ)	2002-09-30	Not applicable

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
24 Multivitamins + Minerals	Potassium Iodide (.1 mg) + Ascorbic acid (150 mg) + Beta carotene (10000 unit) + Biotin (25 mcg) + Calcium (130 mg) + Cholecalciferol (400 unit) + Choline bitartrate (25 mg) + Chromium (20 mcg) + Copper (1 mg) + Cyanocobalamin (25 mcg) + Ferrous fumarate (15 mg) + Folic acid (.8 mg) + Inositol (25 mg) + Magnesium (65 mg) + Manganese (2 mg) + Molybdenum (20 mcg) + Niacin (25 mg) + Calcium pantothenate (25 mg) + Potassium (15 mg) + Pyridoxine hydrochloride (25 mg) + Racemethionine (25 mg) + Riboflavin (25 mg) + Selenium (20 mcg) + Thiamine hydrochloride (25 mg) + Vanadium (20 mcg) + Vitamin A palmitate (5000 unit) + Vitamin E (50 unit) + Zinc (10 mg)	Tablet	Oral	Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.	1997-04-30	2002-07-31
50 Plus Multiple Vitamins & Minerals	Potassium Iodide (0.15 mg) + Ascorbic acid (90 mg) + Biotin (45 mcg) + Calcium (200 mg) + Cholecalciferol (400 unit) + Chromium (10 mcg) + Copper (2 mg) + Cyanocobalamin (25 mcg) + Folic acid (0.4 mg) + Magnesium (100 mg) + Manganese (5 mg) + Molybdenum (25 mcg) + Nicotinamide (40 mg) + Pantothenic acid (10 mg) + Pyridoxine hydrochloride (3 mg) + Riboflavin (3.2 mg) + Selenium (25 mcg) + Thiamine mononitrate (2.25 mg) + Vanadium (10 mcg) + Vitamin A palmitate (6000 unit) + Zinc (15 mg)	Tablet	Oral	Gfr Pharma Ltd.	2002-10-20	2004-06-15
ADDAMEL INFUSION N	Potassium Iodide (166 mcg) + Chromic chloride hexahydrate (53.3 mcg) + Cupric chloride dihydrate (3.4 mg) + Ferric chloride hexahydrate (5.4 mg) + Manganese chloride tetrahydrate (990 mcg) + Sodium selenite pentahydrate (105 mcg) + Sodium fluoride (2.1 mg) + Sodium molybdate dihydrate (48.5 mcg) + Zinc chloride (13.6 mg)	Solution, concentrate	Intravenous	FRESENIUS KABI COLOMBIA S.A.S.	2006-11-10	2009-05-08
Addnutriv	Potassium Iodide (130 mcg / 10 mL) + Chromic chloride (10 mcg / 10 mL) + Cupric Chloride (380 mcg / 10 mL) + Ferric chloride (1100 mcg / 10 mL) + Manganese (55 mcg / 10 mL) + Sodium selenite (79 mcg / 10 mL) + Sodium fluoride (950 mcg / 10 mL) + Sodium molybdate (19 mcg / 10 mL) + Zinc (5000 mcg / 10 mL)	Solution	Intravenous	Fresenius Kabi	2020-12-01	Not applicable
Avon Vitadvance Multi-kids Complete	Potassium Iodide (.075 mg) + Ascorbic acid (100 mg) + Beta carotene (2500 unit) + Biotin (60 mcg) + Calcium (125 mg) + Cholecalciferol (400 unit) + Cupric oxide (1 mg) + Cyanocobalamin (6 mcg) + Ferrous fumarate (4 mg) + Folic acid (.4 mg) + Nicotinamide (20 mg) + Calcium pantothenate (10 mg) + Pyridoxine hydrochloride (2 mg) + Riboflavin (1.7 mg) + Thiamine mononitrate (1.5 mg) + Vitamin A palmitate (2500 unit) + alpha-Tocopherol succinate (20 unit)	Tablet	Oral	Avon Products, Inc.	1994-12-31	2005-07-29
Bear Essentials	Potassium Iodide (0.0304 mg) + Ascorbic acid (12 mg) + Cholecalciferol (80 unit) + Cyanocobalamin (1.2 mcg) + Folic acid (0.080 mg) + Pantothenic acid (2 mg) + Vitamin A (1000 unit) + Vitamin E (6 unit)	Tablet	Oral	Health Asure, Inc.	2003-07-02	2008-06-24
Body Rox	Potassium Iodide (0.05 mg) + Beta carotene (3000.0 unit) + Biotin (100.0 mcg) + Calcium (75.0 mg) + Calcium ascorbate (167.0 mg) + Cholecalciferol (133.0 unit) + Choline bitartrate (15.0 mg) + Chromium (50.0 mcg) + Copper (0.33 mg) + Cyanocobalamin (20.0 mcg) + Folic acid (0.267 mg) + Inositol (10.0 mg) + Magnesium (37.5 mg) + Manganese (1.0 mg) + Molybdenum (15.0 mcg) + Niacin (1.66 mg) + Nicotinamide (3.3 mg) + Calcium pantothenate (10.0 mg) + Pyridoxine hydrochloride (3.0 mg) + Riboflavin (3.0 mg) + Selenium (40.0 mcg) + Silicon (1.0 mg) + Thiamine hydrochloride (3.0 mg) + Vanadium (10.0 mcg) + Zinc (4.0 mg) + alpha-Tocopherol succinate (66.7 unit)	Tablet	Oral	Usana Health Sciences, Inc.	2003-09-02	2008-06-27
C. Vit-min Formula	Potassium Iodide (0.15 mg) + Ascorbic acid (100 mg) + Biotin (30 mcg) + Calcium (175 mg) + Cholecalciferol (400 unit) + Choline (30 mg) + Chromium (50 mcg) + Copper (5 mg) + Cyanocobalamin (100 mcg) + Ferrous fumarate (10 mg) + Folic acid (0.600 mg) + Inositol (30 mg) + Magnesium (80 mg) + Manganese (5 mg) + Molybdenum (25 mcg) + Nicotinamide (50 mg) + Calcium pantothenate (50 mg) + Potassium (40 mg) + Pyridoxine hydrochloride (50 mg) + Racemethionine (3 mg) + Riboflavin (50 mg) + Sodium selenite (200 mcg) + Silicon (0.01 mg) + Thiamine (50 mg) + Vanadium (10 mcg) + Vitamin A (5000 unit) + Zinc (40 mg) + alpha-Tocopherol acetate (100 unit)	Tablet	Oral	Nutramed Laboratories Inc.	Not applicable	Not applicable
Card-floe II Tab	Potassium Iodide (.03 mg) + Ascorbic acid (400 mg) + Beta carotene (1000 unit) + Biotin (5 mcg) + Calcium (42 mg) + Choline (66 mg) + Chromium (13 mcg) + Cyanocobalamin (16 mcg) + Folic acid (.06 mg) + Inositol (4 mg) + Magnesium (42 mg) + Manganese (.8 mg) + Niacin (7 mg) + Nicotinamide (2 mg) + Calcium pantothenate (33 mg) + Potassium (42 mg) + Pyridoxine hydrochloride (15 mg) + Racemethionine (16 mg) + Riboflavin (3 mg) + Selenium (20 mcg) + Thiamine hydrochloride (18 mg) + Vitamin A palmitate (2000 unit) + Vitamin E (60 unit) + Zinc (2.5 mg)	Tablet	Oral	Sisu Inc.	1994-12-31	2009-08-04
Central-vite 18 Essential	Potassium Iodide (0.15 mg / tab) + Ascorbic acid (90 mg / tab) + Beta carotene (3000 unit / tab) + Biotin (45 mcg / tab) + Calcium (175 mg / tab) + Calcium Phosphate (125 mg / tab) + Cholecalciferol (400 unit / tab) + Cupric oxide (2 mg / tab) + Cyanocobalamin (9 mcg / tab) + Ferrous fumarate (10 mg / tab) + Folic acid (0.4 mg / tab) + Magnesium (100 mg / tab) + Nicotinamide (40 mg / tab) + Calcium pantothenate (10 mg / tab) + Pyridoxine hydrochloride (3 mg / tab) + Riboflavin (3.2 mg / tab) + Thiamine mononitrate (2.25 mg / tab) + Vitamin A (2000 unit / tab) + alpha-Tocopherol acetate (25 unit / tab)	Tablet	Oral	Vita Health Products Inc	1998-04-24	2002-07-31

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Addamel N	Potassium Iodide (0.013 mg/1mL) + Chromic chloride hexahydrate (1 ug/1mL) + Cuprous chloride (0.13 mg/1mL) + Ferric chloride (0.11 mg/1mL) + Manganese chloride tetrahydrate (0.027 mg/1mL) + Sodium selenite (3.2 ug/1mL) + Sodium fluoride (0.095 mg/1mL) + Sodium molybdate dihydrate (1.9 ug/1mL) + Zinc chloride (0.65 mg/1mL)	Injection, solution	Intravenous	Fresenius Kabi USA, LLC	2013-05-07	2017-03-31
ADDAMEL N 20 AMPUL	Potassium Iodide (166 mcg/10mL) + Chromic chloride (53.3 mcg/10mL) + Cupric Chloride (3.4 mg/10mL) + Ferric chloride (5.4 mg/10mL) + Manganese chloride (990 mcg/10mL) + Sodium selenite (69 mcg/10mL) + Sodium fluoride (2.1 mg/10mL) + Sodium molybdate (48.5 mcg/10mL) + Zinc chloride (13.6 mg/10mL)	Injection, solution	Intravenous	FRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ.	2020-08-14	Not applicable
ADDAVEN IV INFUZYON ICIN KONSANTRE SOLUSYON	Potassium Iodide (166 mcg/10mL) + Chromic chloride (53.3 mcg/10mL) + Cupric Chloride (1.02 mg/10mL) + Ferric chloride (5.4 mg/10mL) + Manganese chloride (198 mcg/10mL) + Sodium selenite (173 mcg/10mL) + Sodium fluoride (2.1 mg/10mL) + Sodium molybdate (48.5 mcg/10mL) + Zinc chloride (10.5 mg/10mL)	Injection, solution	Intravenous	FRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ.	2020-08-14	Not applicable
BumP DHA	Potassium Iodide (250 ug/1) + Cobamamide (500 mg/1) + Flavin adenine dinucleotide (1 mg/1) + Flavin mononucleotide (2 mg/1) + Iron (15 mg/1) + Leucovorin (1 mg/1) + Levomefolate magnesium (1 mg/1) + Magnesium oxide (125 mg/1) + NADH (25 ug/1) + Omega-3 fatty acids (300 mg/1) + Pyridoxal phosphate (5 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Zinc glycinate (15 1/1)	Capsule	Oral	Centurion Labs	2017-03-24	2017-04-17
Cavan Heme OB	Potassium Iodide (175 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Iron (28 mg/1) + Niacin (17 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Sodium selenate (65 ug/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (15 mg/1) + alpha-Tocopherol succinate (10 [iU]/1)	Tablet	Oral	Seton Pharmaceuticals	2010-08-03	2012-06-10
Cavan Prenatal	Potassium Iodide (150 ug/1) + Ascorbic acid (120 mg/1) + Calcium carbonate (200 mg/1) + Cholecalciferol (420 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (8 ug/1) + Ferrous fumarate (28 mg/1) + Folic acid (1 mg/1) + Niacin (20 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Thiamine mononitrate (3 mg/1) + Vitamin E (30 [iU]/1) + Zinc oxide (15 ug/1)	Tablet	Oral	Seton Pharmaceuticals	2009-07-09	2009-07-22
CitraNatal 90 DHA	Potassium Iodide (150 ug/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (159 mg/1) + Cupric oxide (2 mg/1) + Docusate sodium (50 mg/1) + Ferrous gluconate dihydrate (5 mg/1) + Folic acid (1 mg/1) + Iron (85 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Thiamine mononitrate (4.54 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)	Tablet	Oral	Mission Pharmacal Company	2014-04-11	Not applicable
CitraNatal DHA	Potassium Iodide (150 mg/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (124 mg/1) + Cupric oxide (2 mg/1) + Doconexent (250 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Icosapent (0.625 mg/1) + Iron (27 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)	Kit	Oral	Mission Pharmacal Company	2014-05-22	Not applicable
CitraNatal DHA	Potassium Iodide (150 mg/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (125 mg/1) + Cupric oxide (2 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Iron (27 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)	Tablet	Oral	Mission Pharmacal	2007-11-20	Not applicable
CitraNatal Rx	Potassium Iodide (150 mg/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (124 mg/1) + Cupric oxide (2 mg/1) + Folic acid (1 mg/1) + Iron (27 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)	Tablet	Oral	Mission Pharmacal	2014-08-11	Not applicable

Categories

ATC Codes

S01XA04 — Potassium iodide

• S01XA — Other ophthalmologicals
• S01X — OTHER OPHTHALMOLOGICALS
• S01 — OPHTHALMOLOGICALS
• S — SENSORY ORGANS

V03AB21 — Potassium iodide

• V03AB — Antidotes
• V03A — ALL OTHER THERAPEUTIC PRODUCTS
• V03 — ALL OTHER THERAPEUTIC PRODUCTS
• V — VARIOUS

R05CA02 — Potassium iodide

• R05CA — Expectorants
• R05C — EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS
• R05 — COUGH AND COLD PREPARATIONS
• R — RESPIRATORY SYSTEM

Drug Categories

• Anions
• Antidotes
• Antithyroid agents
• Cough and Cold Preparations
• Electrolytes
• Expectorants
• Iodides
• Iodine Compounds
• Ions
• Minerals
• Ophthalmologicals
• Potassium Compounds
• Potassium Salt
• Sensory Organs
• Thyroid Products

Chemical TaxonomyProvided by Classyfire

Description

This compound belongs to the class of inorganic compounds known as alkali metal iodides. These are inorganic compounds in which the largest halogen atom is Iodine, and the heaviest metal atom is an alkali metal.

Kingdom

Inorganic compounds

Super Class

Mixed metal/non-metal compounds

Class

Alkali metal salts

Sub Class

Alkali metal iodides

Direct Parent

Alkali metal iodides

Alternative Parents

Inorganic salts

Substituents

Alkali metal iodide / Inorganic salt

Molecular Framework

Not Available

External Descriptors

potassium salt (CHEBI:8346)

Affected organisms

Not Available

Chemical Identifiers

UNII

1C4QK22F9J

CAS number

7681-11-0

InChI Key

NLKNQRATVPKPDG-UHFFFAOYSA-M

InChI

InChI=1S/HI.K/h1H;/q;+1/p-1

IUPAC Name

potassium iodide

SMILES

[K+].[I-]

References

Synthesis Reference

Stanley D. Lazarus, "Production of thermally stabilized polyester with alkylene carbonates and sodium or potassium iodide." U.S. Patent US4327207, issued October, 1973.

US4327207

General References

Not Available

External Links

KEGG Drug

D01016

KEGG Compound

C08219

PubChem Compound

4875

PubChem Substance

99443267

ChemSpider

4709

RxNav

8597

ChEBI

8346

ChEMBL

CHEMBL1141

PharmGKB

PA451060

Wikipedia

Potassium_iodide

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Completed	Treatment	Dental Decay	1
4	Completed	Treatment	Diabetic Macular Edema (DME)	1
4	Completed	Treatment	Graves' Disease / Hyperthyroidism	1
4	Completed	Treatment	Hyperemesis Gravidarum / Morning Sickness / Nausea / Pregnant State / Vomiting	1
4	Completed	Treatment	Pain	1
4	Completed	Treatment	Pregnant State	1
4	Not Yet Recruiting	Treatment	Dental Caries in Children	1
4	Recruiting	Treatment	Hyperthyroidism, Autoimmune	1
3	Not Yet Recruiting	Treatment	Hyperthyroidism	1
3	Recruiting	Other	Graves' Disease	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Injection, solution	Intravenous drip
Injection, solution, concentrate	Intravenous
Tablet, chewable	Oral
Bar, chewable	Oral
Capsule	Oral
Solution / drops	Ophthalmic
Tablet, extended release	Oral
Tablet, film coated
Solution	Intravenous
Syrup
Syrup	Oral
Gel	Oral
Liquid	Oral
Liquid	Topical
Tablet, coated	Oral
Capsule	Oral	0.22 mg
Solution	Topical
Tablet, extended release	Oral	300 mcg / tab
Tablet	Oral	.5 mg / tab
Solution	Oral
Tablet	Oral	65 mg/1
Tablet	Oral	0.131 mg
Tablet	Oral	0.196 mg
Tablet	Oral	0.262 mg
Tablet	Oral	2 mg
Tablet	Oral
Tablet, effervescent	Oral
Liquid	Intravenous
Solution, concentrate	Intravenous
Injection, solution	Intravenous
Injection, solution, concentrate	Intravenous; Parenteral
Injection, solution, concentrate	Parenteral
Powder	Not applicable	1 kg/1kg
Capsule, gelatin coated	Oral
Pill	Oral
Tablet	Oral	130 mg/1
Tablet	Oral
Kit	Oral
Powder	Topical
Solution	Oral	1 g/1mL
Solution / drops	Oral
Tablet	Oral	0.09 mg
Tablet	Oral	130 mg
Tablet	Oral	65 mg
Solution	Oral	65 mg/1mL
Injection, solution	Parenteral
Capsule, liquid filled	Oral
Tablet, film coated	Oral
Solution / drops	Ophthalmic
Powder	Oral
Solution	Oral	1.5 g
Tincture	Topical
Solution
Tablet	Oral	150 mg

Prices

Not Available

Patents

Not Available

Properties

State

Solid

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
logP	0.2	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 Å2	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	0 m3·mol-1	ChemAxon
Polarizability	1.78 Å3	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted ADMET Features

Property	Value	Probability
Human Intestinal Absorption	+	0.7647
Blood Brain Barrier	+	0.9702
Caco-2 permeable	+	0.6625
P-glycoprotein substrate	Non-substrate	0.8989
P-glycoprotein inhibitor I	Non-inhibitor	0.984
P-glycoprotein inhibitor II	Non-inhibitor	0.9854
Renal organic cation transporter	Non-inhibitor	0.9282
CYP450 2C9 substrate	Non-substrate	0.8261
CYP450 2D6 substrate	Non-substrate	0.7789
CYP450 3A4 substrate	Non-substrate	0.7857
CYP450 1A2 substrate	Non-inhibitor	0.7164
CYP450 2C9 inhibitor	Non-inhibitor	0.8527
CYP450 2D6 inhibitor	Non-inhibitor	0.9142
CYP450 2C19 inhibitor	Non-inhibitor	0.8842
CYP450 3A4 inhibitor	Non-inhibitor	0.9317
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.9022
Ames test	Non AMES toxic	0.6838
Carcinogenicity	Carcinogens	0.659
Biodegradation	Not ready biodegradable	0.5913
Rat acute toxicity	2.9202 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.9535
hERG inhibition (predictor II)	Non-inhibitor	0.9657

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)

Not Available

Spectra

Not Available

Targets

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Details1. Tyrosine

Kind

Small molecule

Organism

Humans

Pharmacological action

Unknown

Actions

Binder

References

1. Pisarev MA, Aiello LO: Studies on the mechanism of action of potassium iodide on thyroid protein biosynthesis. Acta Endocrinol (Copenh). 1976 Jun;82(2):298-305. [Article]
2. Foldes J, Gesztesi E, Juhasz J: Mechanism of action of di-iodotyrosine and of iodine. Acta Med Acad Sci Hung. 1974;31(1-2):131-7. [Article]

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Drug created on May 16, 2010 23:39 / Updated on July 29, 2021 06:27