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Displaying results 1891 - 1900 of 10000 in total
  1. Drug

    Trihexyphenidyl

    go.drugbank.com/drugs/DB00376
    ApprovedInvestigational

    [A229103] Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment due to significant adverse effects. … [L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity.

  2. Drug

    Piperonyl butoxide

    go.drugbank.com/drugs/DB09350
    ApprovedVet approved

    Piperonyl butoxide (PBO) is an organic compound used as a component of pesticide formulations. It is used for the treatment of head, pubic (crab), and body lice. Piperonyl butoxide is a synergist. … Piperonyl butoxide is a semisynthetic derivative of safrole.

    Mixtures: El piojito Lice Killing, Dg Health Lice Killing Maximum StrengthCategories: Compounds used in a research, industrial, or household setting
  3. Drug

    Cupric Chloride

    go.drugbank.com/drugs/DB09131
    Approved

    Cupric chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).

    Synonyms: copper(II) chlorideMixtures: Tracel Injektionslösung in einer Fertigspritze, Trace Elements Solution Inj
  4. Drug

    Lamivudine

    go.drugbank.com/drugs/DB00709
    ApprovedInvestigational

    A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. … It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).

    Mixtures: ABACAVIR E LAMIVUDINA DOC GENERICI, ZOVILAM PED DT®Categories: Antivirals used in combination for the treatment of HIV infections
  5. Pathway

    Acylcarnitine (2E)-dec-2-enoylcarnitine

    smpdb.ca/view/SMP0123866
    Metabolic

    Once in the matrix, (2E)-dec-2-enoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form (2E)-dec-2-enoyl-CoA and L-carnitine … In forming an acylcarnitine derivative, (2E)-dec-2-enoyl-CoA reacts with L-carnitine to form (2E)-dec-2-enoylcarnitine. This reaction is catalyzed by carnitine O-palmitoyltransferase.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
  6. Pathway

    Acylcarnitine (2Z)-dec-2-enedioylcarnitine

    smpdb.ca/view/SMP0123876
    Metabolic

    Once in the matrix, (2Z)-dec-2-enedioylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form (2Z)-dec-2-enedioyl-CoA and L-carnitine … In forming an acylcarnitine derivative, (2Z)-dec-2-enedioyl-CoA reacts with L-carnitine to form (2Z)-dec-2-enedioylcarnitine. This reaction is catalyzed by carnitine O-palmitoyltransferase.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
  7. Pathway

    Acylcarnitine (4Z)-dec-4-enedioylcarnitine

    smpdb.ca/view/SMP0123878
    Metabolic

    Once in the matrix, (4Z)-dec-4-enedioylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form (4Z)-dec-4-enedioyl-CoA and L-carnitine … In forming an acylcarnitine derivative, (4Z)-dec-4-enedioyl-CoA reacts with L-carnitine to form (4Z)-dec-4-enedioylcarnitine. This reaction is catalyzed by carnitine O-palmitoyltransferase.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
  8. Drug

    Ivermectin

    go.drugbank.com/drugs/DB00602
    ApprovedInvestigationalVet approved

    [L31453] Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de … Applied topically, it may be used in the treatment of head lice infestation.

    Categories: Compounds used in a research, industrial, or household settingProducts: I-Dectin 0.5 % Pour-On, I-Dectin 0.4% w/v Oral Solution
  9. Drug

    Zolbetuximab

    go.drugbank.com/drugs/DB15118
    ApprovedInvestigational

    [L51923] It is specifically targeted against CLDN18.2, a membrane protein normally found in gastric mucosal cells which is overexpressed in 30-50% of gastric and gastroesophageal junction (GEJ) adenocarcinomas … [A264723] Zolbetuximab was approved by the FDA in October 2024 for use in patients with HER2 negative, CLDN18.2-positive gastric and GEJ adenocarcinomas.[L51943,L51923]

  10. Drug

    Lorlatinib

    go.drugbank.com/drugs/DB12130
    ApprovedInvestigational

    include lorlatinib as a first-line treatment option in advanced ALK-positive NSCLC. … It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-positive non-small cell lung cancer, followed by an expanded approval in 2022 to