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Ajmaline
go.drugbank.com/drugs/DB01426ApprovedWithdrawnAn alkaloid found in the root of Rauwolfia serpentina, among other plant sources. … It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials.
Categories: Antiarrhythmics, Class I, Antiarrhythmics, Class IaErtugliflozin
go.drugbank.com/drugs/DB11827ApprovedInvestigationalErtugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. … [A31581] Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018.[L48621]
Categories: Drugs Used in DiabetesTeduglutide
go.drugbank.com/drugs/DB08900ApprovedInvestigationalTeduglutide is a glucagon-like peptide-2 (GLP-2) analogue. It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant DNA technology. … The significance of this substitution is that teduglutide is longer acting than endogenous GLP-2 as it is more resistant to proteolysis from dipeptidyl peptidase-4. FDA approved on December 21, 2012.
Categories: Compounds used in a research, industrial, or household settingSynonyms: Glucagon-like peptide II (2-glycine) (human)Alkaline Phosphatase
go.drugbank.com/drugs/DB05768InvestigationalAlkaline Phosphatase (AP) is an oral treatment and has a very favorable side-effect profile. … AP only acts locally in the colon to reduce the continuous inflammation of the colon by endotoxin from Gram-negative bacteria and extracellular ATP in UC patients.
Denileukin diftitox
go.drugbank.com/drugs/DB00004ApprovedInvestigationalapproved to treat a human disease in the US. … Denileukin diftitox is an IL2-receptor-directed cytotoxin, is a recombinant DNA-derived fusion protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met<sub>1</sub>-Thr<sub
Eladocagene exuparvovec
go.drugbank.com/drugs/DB16780ApprovedInvestigational[A253687] It was subsequently approved by the FDA in November 2024.[L51898,L51893] … Eladocagene exuparvovec is a recombinant adeno-associated virus-2 (AAV2)-based gene therapy that expresses human aromatic L-amino acid decarboxylase (AADC), and it is used to treat AADC deficiency, a fatal
Trimethoprim
go.drugbank.com/drugs/DB00440ApprovedInvestigationalVet approvedTrimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it … [L11893,L11830] It is structurally and chemically related to [pyrimethamine], another antifolate antimicrobial used in the treatment of plasmodial infections.[T707]
Mixtures: SEPTRIN IV 5 ML 10 AMPUL, Sulfamethoxazole and Trimethoprim for Injection, USPProstaglandin E2 receptor EP1 subtype
go.drugbank.com/bio_entities/BE0000064TargetHumansReceptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system.
Polypeptides: Prostaglandin E2 receptor EP1 subtypeSynonyms: PGE receptor EP1 subtype, Prostanoid EP1 receptorRetinoic acid receptor RXR-beta
go.drugbank.com/bio_entities/BE0000078TargetHumansReceptor for retinoic acid.
Polypeptides: Retinoic acid receptor RXR-betaSynonyms: Retinoid X receptor beta, Nuclear receptor subfamily 2 group B member 2Glutamate receptor ionotropic, kainate 1
go.drugbank.com/bio_entities/BE0000346TargetHumansThe receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist … Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid.
Polypeptides: Glutamate receptor ionotropic, kainate 1Synonyms: Glutamate receptor 5, Excitatory amino acid receptor 3