DB01426ApprovedWithdrawnSmall molecule
Ajmaline is an antiarrhythmic used to manage a variety of forms of tachycardias. An alkaloid found in the root of Rauwolfia serpentina, among other plant sources.
- Mechanism
- Curator reviewed
The class I antiarrhythmic agents interfere with the sodium channel. A class IA agent lengthens the action potential (right shift) which brings about improvement in abnormal heart rhythms. This drug in particular has a high affinity for the Nav 1.5 sodium channel.
- Primary indication
- For use as an antiarrhythmic agent.Curator reviewed · 4 structured indications
- Formula / weight
- C20H26N2O2 · 326.4326 g/mol (avg)
- Also known as
- Ajmalin
Resolves to
Clinical / RWD
Structure
InChIKey
CJDRUOGAGYHKKD-HEFSZTOGSA-NSMILES[H][C@]12C[C@]34[C@H](O)C1[C@@]1([H])C[C@]([H])(N2[C@H](O)[C@H]1CC)[C@]3([H])N(C)C1=CC=CC=C41Targets
What you can answer from here — as of September 23, 2026
1Protein targetEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Ajmaline, and which of those have an active Phase 3 trial?
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