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Alvimopan
go.drugbank.com/drugs/DB06274ApprovedInvestigationalIt is used to avoid postoperative ileus following small or large bowel resection and accelerates the gastrointestinal recovery period.
Categories: Drugs for ConstipationChronic Myelogenous Leukemia (CML)
go.drugbank.com/conditions/DBCOND0040386Synonyms: Chronic myelogenous leukemia, no International Classification of Diseases for Oncology subtypeButenafine
go.drugbank.com/drugs/DB01091ApprovedIn particular, butenafine acts to inhibit the activity of the squalene epoxidase enzyme that is essential in the formation of sterols necessary for fungal cell membranes. … Butenafine's mechanism of action is believed to involve the synthesis inhibition of sterols.
Categories: Antifungals for Topical Use, Antifungals for Dermatological UseTrametinib
go.drugbank.com/drugs/DB08911ApprovedInvestigationalOriginally developed by Japan Tobacco, trametinib was initially investigated for treating inflammation, but further studies for this indication were not pursued.[A258298] … [A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma.
Mephentermine
go.drugbank.com/drugs/DB01365ApprovedWithdrawnIt is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. … Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeAtenolol
go.drugbank.com/drugs/DB00335ApprovedInvestigationalLater they continued to be investigated for use in heart failure throughout the 1970-1980s. … [A235865] The use of atenolol may need to be based on more patient factors than hypertension alone.[A235850,A235855,A235860,A235865]
Mixtures: NIFETEX-TR CAPSULE, ATENOLOL CO RATIO 100/25MGCategories: Antihypertensive Agents Indicated for HypertensionCapmatinib
go.drugbank.com/drugs/DB11791ApprovedInvestigational[L13347] The presence of the mutation must be confirmed by an FDA-approved test, such as the FoundationOne CDx assay (manufactured by Foundation Medicine, Inc.), which was approved by the FDA on the same … Manufactured by Novartis and marketed under the brand name Tabrecta, capmatinib was granted accelerated approval by the FDA on May 6, 2020,[L13380] for the treatment of NSCLC in patients whose tumors have
Gatifloxacin
go.drugbank.com/drugs/DB01044ApprovedInvestigationalWithdrawnThe FDA withdrew its approval for the use of non-ophthalmic drug products containing gatifloxacin due to the high prevalence of gatifloxacin-associated dysglycemia adverse event reports and the high incidence … It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseCyclizine
go.drugbank.com/drugs/DB01176ApprovedWithdrawnA histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
Categories: Antihistamines for Systemic UseDronedarone
go.drugbank.com/drugs/DB04855ApprovedInvestigational[A34604] This ultimately leads to reduced tissue accumulation of the drug and decreased risk for organ toxicities, such as thyroid and pulmonary toxicities. … [A34604,L8699] Dronedarone is a related benzofuran compound to amiodarone but its chemical structure lacks iodine moieties which are associated with amiodarone-induced thyroid problems.