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Insulin pork
go.drugbank.com/drugs/DB00071ApprovedInsulin isolated from pig pancreas. Composed of alpha and beta chains, processed from pro-insulin. Forms a hexameric structure.
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersLovastatin
go.drugbank.com/drugs/DB00227ApprovedInvestigationalstatin medications are considered equally effective from a clinical standpoint, [rosuvastatin] is considered the most potent; doses of 10 to 40mg [rosuvastatin] per day were found in clinical studies to result
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsConjugated estrogens
go.drugbank.com/drugs/DB00286ApprovedInvestigationalThe conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later con...
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesVindesine
go.drugbank.com/drugs/DB00309ApprovedInvestigationalWithdrawnVinblastine derivative with antineoplastic activity against cancer. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (antineoplastic combined chemotherapy protocols).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesInterferon alfa-2b
go.drugbank.com/drugs/DB00105ApprovedInvestigationalInterferon alpha 2b (human leukocyte clone hif-sn 206 protein moiety reduced). A type I interferon consisting of 165 amino acid residues with arginine in position 23. This protein is produced by recombinant DNA technology and resembles i...
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme InhibitorsAdemetionine
go.drugbank.com/drugs/DB00118ApprovedInvestigationalNutraceuticalPhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Categories: Cytochrome P-450 CYP2E1 Inhibitors, Cytochrome P-450 Enzyme InhibitorsMenadione
go.drugbank.com/drugs/DB00170ApprovedNutraceuticalA synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP1A2 InhibitorsPravastatin
go.drugbank.com/drugs/DB00175ApprovedInvestigationalPravastatin is the 6-alpha-hydroxy acid form of mevastatin. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug....
Categories: P-glycoprotein substratesFluvoxamine
go.drugbank.com/drugs/DB00176ApprovedInvestigationalFluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesEsmolol
go.drugbank.com/drugs/DB00187ApprovedInvestigationalWithdrawnEsmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker. It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing acti...
Synonyms: (±)-methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate, methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamateCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Substrates