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Displaying results 1921 - 1930 of 10000 in total
  1. Drug

    Nonoxynol-9

    go.drugbank.com/drugs/DB06804
    ApprovedWithdrawn

    Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. … N-9 has been in use for more than 30 years as an over-the-counter (OTC) drug in creams, gels, foams and condom lubricants.

    Synonyms: Nonoxynol 9, Nonoxynol-9Categories: Compounds used in a research, industrial, or household setting
  2. Drug

    Plicamycin

    go.drugbank.com/drugs/DB06810
    ApprovedWithdrawn

    Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued pl...

    Categories: Compounds used in a research, industrial, or household setting
  3. Drug

    Pralatrexate

    go.drugbank.com/drugs/DB06813
    ApprovedInvestigational

    [A246693] Pralatrexate is designed to have a higher affinity for the reduced folate carrier, a protein that is overexpressed in malignant cells and is upregulated by oncogenes. … Pralatrexate is an antifolate for the treatment of relapsed or refractory peripheral T-cell lymphoma [L37674].

    Synonyms: (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}amino)pentanedioic acid, N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acidCategories: Heterocyclic Compounds, 2-Ring
  4. Drug

    CHIR-124

    go.drugbank.com/drugs/DB06852
    Experimental

    CHIR-124 is a potent inhibitor of Chk1 that potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo.

    Categories: Heterocyclic Compounds, 2-Ring
  5. Drug

    (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide

    go.drugbank.com/drugs/DB06941
    Experimental

    (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide is a solid. This compound belongs to the phenylpiperazines. … These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group. This drug targets the protein S100B.

    Synonyms: (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide
  6. Drug

    N-(4-carbamimidoylbenzyl)-1-(3-phenylpropanoyl)-L-prolinamide

    go.drugbank.com/drugs/DB06942
    Experimental

    N-(4-carbamimidoylbenzyl)-1-(3-phenylpropanoyl)-l-prolinamide is a solid. This compound belongs to the alpha amino acid amides. These are amide derivatives of alpha amino acids.

    Synonyms: N-(4-carbamimidoylbenzyl)-1-(3-phenylpropanoyl)-L-prolinamide
  7. Drug

    JNJ-27390467

    go.drugbank.com/drugs/DB06962
    Experimental

    JNJ-27390467 is a potent, nonpeptide inhibitor of human mast cell tryptase.

  8. Drug

    Paratoulene phosphate

    go.drugbank.com/drugs/DB04495
    Experimental

    Categories: Heterocyclic Compounds, 1-Ring
  9. Drug

    5-Nitroindazole

    go.drugbank.com/drugs/DB04534
    Experimental

    Synonyms: 5-Nitroindazole, 5-Nitro-1H-indazoleCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  10. Drug

    1-benzylimidazole

    go.drugbank.com/drugs/DB04581
    Experimental

    1-benzylimidazole, an N-imidazole derivative, has been shown to have strong cardiotonic activity.

    Synonyms: 1-benzylimidazole, 1-benzyl-1H-imidazoleCategories: Heterocyclic Compounds, 1-Ring