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Papain
go.drugbank.com/drugs/DB11193ApprovedWithdrawnWhile it has been used for the treatment of inflammation and pain via topical administration, papain has also shown to have anthelmintic and tooth-whitening properties. … Present in over-the-counter mixture products consisting of different digestive enzymes, its active site contains a catalytic diad that plays a role in breaking peptide bonds.
Mixtures: Pro Gest TabCarbamide peroxide
go.drugbank.com/drugs/DB11129ApprovedInvestigationalSome adverse effects of carbamide peroxide as a dental bleaching agent include dentin sensitivity and/or gingival irritation led by unstable and reactive H+ free radicals and low pH from prolonged use. … As it is a source of hydrogen peroxide, it can be found in disinfecting and dental bleaching products.
Categories: Compounds used in a research, industrial, or household settingVericiguat
go.drugbank.com/drugs/DB15456ApprovedInvestigational[A227458] As a direct stimulator of sGC, vericiguat mitigates the need for a functional NO-sGC-cGMP axis and thereby helps to prevent the myocardial and vascular dysfunction associated with decreased sGC … to its structure have dramatically decreased its susceptibility to oxidative metabolism,[A227458] resulting in a relatively long half-life and allowing for once-daily dosing.
Autologous cultured chondrocytes
go.drugbank.com/drugs/DB10997ApprovedInvestigationalThe surgical implantation shows a tolerable safety profile and efficacy up to 4 years, but it is not indicated for patients with osteoarthritis. … It serves as an alternative repair treatment for patients with inadequate response to pre-existing surgical methods.
Elapegademase
go.drugbank.com/drugs/DB14712ApprovedIt can be defined molecularly as a genetically modified bovine adenosine deaminase with a modification in cysteine 74 for serine and with about 13 methoxy polyethylene glycol chains bound via carbonyl … Elapegademase is a PEGylated recombinant adenosine deaminase.
Synonyms: (74-SERINE (C>S),245-THREONINE (A>T))BOS TAURUS ADENOSINE DEAMINASE (BOVINE ADENOSINE AMINOHYDROLASE, EC=3.5.4.4)-(1-356)-PEPTIDE PRODUCED IN ESCHERICHIA COLI, AN AVERAGE OF 13 RESIDUES ARE SUBSTITUTEDLX1031
go.drugbank.com/drugs/DB05199InvestigationalLX1031 was generated by Lexicon medicinal chemists, and its target was internally identified as a key control point for the regulation of peripheral serotonin levels. … LX1031 is designed to act locally in the gastrointestinal tract by reducing the serotonin available for receptor activation, without affecting serotonin levels in the brain or its central nervous system
Amoxapine
go.drugbank.com/drugs/DB00543ApprovedSee toxicity section below for a complete listing of side effects. … They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation.
Categories: Antidepressive Agents Indicated for Depression, Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic IndexTezacaftor
go.drugbank.com/drugs/DB11712ApprovedInvestigationalTezacaftor is a drug of the cystic fibrosis transmembrane conductance regulator (CFTR) corrector class. … Alterations in the CFTR gene result in altered production, misfolding, or function of the protein and consequently abnormal fluid and ion transport across cell membranes.
Sulfamerazine
go.drugbank.com/drugs/DB01581ApprovedVet approvedWithdrawnA sulfanilamide that is used as an antibacterial agent.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseRanibizumab
go.drugbank.com/drugs/DB01270ApprovedInvestigationalRanibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment directed against human vascular endothelial growth factor A (VEGF-A), which is a glycoprotein implicated in the pathophysiology … In order to improve drug delivery to the target organ, ranibizumab is available for intravitreal use.
Products: Lucentis 10mg/ml Solution for Injection, ACCENTRIX 10MG/ML SOLUTION FOR INJECTION