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Vepdegestrant
go.drugbank.com/drugs/DB19006ApprovedInvestigational[A275508, A275509] On May 1, 2026, the FDA granted approval for vepdegestrant tablets under the trade name VEPPANU. … [L56181] It is indicated for the treatment of adults with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative, and ESR1-mutated advanced or metastatic breast cancer
Categories: Selective Estrogen Receptor Degraders, P-glycoprotein inhibitorsRubella virus vaccine
go.drugbank.com/drugs/DB10317ApprovedInvestigationalRubella virus vaccine is a live attenuated virus vaccine for active immunization against rubella (German measles) that is subcutaneously administered.
Mixtures: Sterile Diluent for M-M-R II, <p>SII MEASLES,MUMPS & RUBELLA VACCINE LIVE ATTENUATED (FREEZE-DRIED) SINGLE DOSE</p>Categories: Antiinfectives for Systemic UseAmoxapine
go.drugbank.com/drugs/DB00543ApprovedThey contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation. … See toxicity section below for a complete listing of side effects.
Categories: Antidepressive Agents Indicated for Depression, P-glycoprotein inhibitorsFlavin adenine dinucleotide
go.drugbank.com/drugs/DB03147Approved(Lehninger, Principles of Biochemistry, 1982, p972) Flavin adenine dinucleotide is approved for use in Japan under the trade name Adeflavin as an ophthalmic treatment for vitamin B2 deficiency.
Mixtures: EnBrace HRCategories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesLithium carbonate
go.drugbank.com/drugs/DB14509ApprovedInvestigationalLithium has been used to treat manic episodes since the 19th century . Though it is widely used, its mechanism of action is still unknown[FDA Label] . Lithium carbonate has a narrow therapeutic range and so careful monitoring is required...
Mixtures: BIOGROW MINBictegravir
go.drugbank.com/drugs/DB11799ApprovedInvestigationalIt has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet.[L43677]
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseBrexpiprazole
go.drugbank.com/drugs/DB09128ApprovedInvestigationalCompared to aripiprazole, brexpiprazole has less potential for partial agonist-mediated adverse effects such as extrapyramidal symptoms, which is attributed to lower intrinsic activity at the D2 receptor … Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM).
Categories: Antidepressive Agents Indicated for Depression, Cytochrome P-450 SubstratesIsoflavone
go.drugbank.com/drugs/DB12007ApprovedInvestigationalWithdrawnThe main soy isoflavones are mostly present in glycosylated forms and include [DB01645], [DB13182], and glycitein, which accounts for approximately 50%, 40%, and 10%, respectively, of the total soybean … The clinical benefits of soy proteins have been studied and demonstrated for many years, with some evidence of soy products associated with a reduced incidences of coronary heart disease, atherosclerosis
CM4620
go.drugbank.com/drugs/DB16466InvestigationalCM4620 (Zegocractin), is under investigation in multiple clinical trials, including NCT04195347 (pancreatitis due to asparaginase), NCT03709342 (PK/PD study in acute pancreatitis), NCT03401190 and NCT04681066
Categories: Experimental Unapproved Treatments for COVID-19Pralsetinib
go.drugbank.com/drugs/DB15822ApprovedInvestigational[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers, including non-small cell lung cancer. … Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.
Categories: P-glycoprotein inhibitors, P-glycoprotein substrates