Search

Displaying results 1931 - 1940 of 2815 in total

Drug
Thiothixene
go.drugbank.com/drugs/DB01623
Approved
A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates
Drug
Lincomycin
go.drugbank.com/drugs/DB01627
ApprovedInvestigationalVet approved
Lincomycin is a lincosamide antibiotic first isolated from the soil bacterium Streptomyces lincolnensis in Lincoln, Nebraska. Clinical use of lincomycin has largely been superseded by its semisynthetic derivative clindamycin due to its h...
Drug
Genistein
go.drugbank.com/drugs/DB01645
Investigational
An isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce ...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
Drug
Topiroxostat
go.drugbank.com/drugs/DB01685
Investigational
Topiroxostat is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout. Xanthine oxidase, or xanthine oxidoreductase (XOR), regulates purine metabolism, and inhibition of the enzyme result...
Categories: Cytochrome P-450 CYP2C19 Inhibitors, Cytochrome P-450 CYP2C8 Inhibitors
Drug
Prasterone
go.drugbank.com/drugs/DB01708
ApprovedInvestigationalNutraceutical
Prasterone, also known as dehydroepiandrosterone (DHEA) is a major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testost...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inhibitors
Drug
Cholesterol
go.drugbank.com/drugs/DB04540
ApprovedInvestigationalWithdrawn
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Categories: P-glycoprotein inhibitors
Drug
Thiotepa
go.drugbank.com/drugs/DB04572
ApprovedInvestigational
N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InhibitorsProducts: THIO SPAL-P 100
Drug
Camptothecin
go.drugbank.com/drugs/DB04690
Investigational
Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demon...
Categories: P-glycoprotein substrates
Drug
Prenylamine
go.drugbank.com/drugs/DB04825
ApprovedWithdrawn
Prenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
Drug
Urethane
go.drugbank.com/drugs/DB04827
ApprovedWithdrawn
Urethane, formerly marketed as an inactive ingredient in Profenil injection, was determined to be carcinogenic and was removed from the Canadian, US, and UK markets in 1963.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 Substrates