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Efonidipine
go.drugbank.com/drugs/DB09235InvestigationalEfonidipine is a calcium channel blocker of the dihydropyridine class, commercialized by Shionogi & Co. (Japan). Initially, it was marketed in 1995 under the trade name, Landel. The drug has been shown to block T-type in addition to ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsAmitriptyline
go.drugbank.com/drugs/DB00321ApprovedInvestigationalAmitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in...
Mixtures: Sentravil PM-25Categories: Adrenergic alpha-1 Receptor Antagonists, Serotonin Receptor AntagonistsPolymyxin B
go.drugbank.com/drugs/DB00781ApprovedInvestigationalVet approvedPolymyxin B was discovered in the 1940s . They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes . Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxi...
Mixtures: OTEK-P EAR DROPS, PS-2261 Triple Antibiotic, 0.5gFinasteride
go.drugbank.com/drugs/DB01216ApprovedInvestigationalFinasteride is a synthetic 4-azasteroid compound and specific inhibitor of steroid Type II 5α-reductase, which is an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). It works in a similar fa...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesCholine
go.drugbank.com/drugs/DB00122ApprovedInvestigationalNutraceuticalA basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
Mixtures: Sentravil PM-25, Sentrazolpidem PM-5Cubilin
go.drugbank.com/bio_entities/BE0000936TargetTransporterHumansEndocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake (PubMed:10371504, PubMed:11606717, PubMed:11717447, PubMed:14576052, PubMed:9572993).
Synonyms: 460 kDa receptor, Intestinal intrinsic factor receptorDexchlorpheniramine maleate
go.drugbank.com/drugs/DB09555ApprovedDexchlorpheniramine is the S-enantiomer of chlorpheniramine which is a 1st generation anti-histamine. Dexchlorpheniramine has more pharmacological activity than the R and so is more potent than the racemic mixture.
Mixtures: Corzall PECategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsRemdesivir
go.drugbank.com/drugs/DB14761ApprovedInvestigationalSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress s...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesP2Y purinoceptor 2
go.drugbank.com/bio_entities/BE0002401TargetHumansReceptor for ATP and UTP coupled to G proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP
Synonyms: ATP receptor, P2U receptor 1Function: A1 adenosine receptor bindingMepolizumab
go.drugbank.com/drugs/DB06612ApprovedInvestigationalEosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically defined as absolute eosinophil levels of 1500/mm3 or more) is associated with a spectrum of diseases, including severe asthma, eosinoph...