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Fenretinide
go.drugbank.com/drugs/DB05076InvestigationalA synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.
Synonyms: N-(4-hydroxyphenyl)all-trans retinamideCategories: Compounds used in a research, industrial, or household settingPoliglusam
go.drugbank.com/drugs/DB11234ApprovedInvestigationalPoliglusam, or chitosan, is a linear polysaccharide consisting of D-glucosamine and N-acetyl-D-glucosamine. … In comparison, commercial poliglusam is derived from deacetylation of chitin contained in the shells of various sea crustaceans such as shrimps [L999].
Categories: Compounds used in a research, industrial, or household settingDaclatasvir
go.drugbank.com/drugs/DB09102ApprovedInvestigationalWithdrawnThe same dosing regimen can be used as first-line therapy in patients with genotype 3 without cirrhosis and second-line therapy in genotype 3 patients with compensated cirrhosis. … Binding to the N-terminus of the D1 domain of NS5A prevents its interaction with host cell proteins and membranes required for virion replication complex assembly.
Products: I-HEP CLASTAVIR 30, I-HEP CLASTAVIR 60Lenvatinib
go.drugbank.com/drugs/DB09078ApprovedInvestigationalThese receptor tyrosine kinases (RTKs) located in the cell membrane play a central role in the activation of signal transduction pathways involved in the normal regulation of cellular processes, such as … In particular, VEGF has been identified as a crucial regulator of both physiologic and pathologic angiogenesis and increased expression of VEGF is associated with a poor prognosis in many types of cancers
Aluminum oxide
go.drugbank.com/drugs/DB11342ApprovedWithdrawnIt is amphoteric in nature, and is used in various chemical, industrial and commercial applications. It is considered an indirect additive used in food contact substances by the FDA.
Mixtures: POLGENTEC 2-120 GBQ GENERADOR DE RADIONUCLEIDOSCemiplimab
go.drugbank.com/drugs/DB14707ApprovedInvestigational[A39201,A254177,L4615] It was later approved to be used in basal cell carcinoma and non-small non-small cell lung cancer. … [L43867] The EMA then approved Libtayo (cemiplimab) for that indication later in the same year. [L43872]
Dihydrocodeine
go.drugbank.com/drugs/DB01551ApprovedIllicitIt was marketed in 1911. … It is semi-synthetic, and was developed in Germany in 1908 during an international search to find a more effective antitussive agent to help reduce the spread of airborne infectious diseases such as tuburculosis
International brands: DF-118 ForteMixtures: Duohist DH, EndaCof DHIdursulfase
go.drugbank.com/drugs/DB01271ApprovedInvestigationalIdursulfase is a purified form of human iduronate-2-sulfatase, a lysosomal enzyme. Idursulfase is produced by recombinant DNA technology in a human cell line. … Idursulfase is an enzyme that hydrolyzes the 2-sulfate esters of terminal iduronate sulfate residues from the glycosaminoglycans dermatan sulfate and heparan sulfate in the lysosomes of various cell types
Trametinib
go.drugbank.com/drugs/DB08911ApprovedInvestigational[A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma. … [L45583] Trametinib is currently approved to treat a variety of cancers with BRAF mutations, such as non-small cell lung cancer and thyroid cancer, as monotherapy or in combination with [dabrafenib], a
Ripretinib
go.drugbank.com/drugs/DB14840ApprovedInvestigational[L13769] It is the first drug approved as a fourth-line therapy in the specific setting of prior treatment with a minimum of 3 other kinase inhibitors.[L13778] … Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA on May 15, 2020.