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Displaying results 11 - 20 of 358 in total
  1. Target

    Human Retinoid X Receptors (RXRs)

    go.drugbank.com/bio_entities/BE0010096
    TargetHumans

    Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675). … Acts as an enhancer of RARA binding to RARE DNA element (PubMed:28167758). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (PubMed:12145331, PubMed:15509776).

    Function: DNA-binding transcription factor activity, RNA polymerase II-specific
  2. Target

    Coproporphyrinogen III oxidase

    go.drugbank.com/bio_entities/BE0003808
    TargetBacillus subtilis (strain 168)

    Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III (PubMed:7928957, PubMed:8288631, PubMed:9217019, PubMed:9784236). … Can also oxidize mesoporphyrinogen IX, but not uroporphyrinogen III (PubMed:7928957, PubMed:8288631, PubMed:9784236).

    Polypeptides: Coproporphyrinogen III oxidase
  3. Target

    Coproporphyrin III ferrochelatase

    go.drugbank.com/bio_entities/BE0001307
    TargetBacillus subtilis (strain 168)

    Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III (PubMed:25646457, PubMed:25908396). … Has weaker activity with 2,4 disulfonate, deuteroporphyrin and 2,4 hydroxyethyl (PubMed:12761666, PubMed:25646457).

    Polypeptides: Coproporphyrin III ferrochelataseSynonyms: Water-soluble ferrochelatase
  4. Target

    Apolipoprotein C-III

    go.drugbank.com/bio_entities/BE0008880
    TargetHumans

    Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed:18201179 … Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806).

    Polypeptides: Apolipoprotein C-IIISynonyms: ApoC-III
  5. Target

    Human Vascular Endothelial Growth Factors (VEGFs)

    go.drugbank.com/bio_entities/BE0010103
    TargetHumans

    Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors … Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors

  6. Target

    Uroporphyrinogen-III C-methyltransferase

    go.drugbank.com/bio_entities/BE0002528
    TargetPseudomonas denitrificans

    It is a step in the biosynthesis of both cobalamin (vitamin B12) and siroheme. Neither uroporphyrin III nor the chlorin (factor I) is a substrate of SUMT. … Catalyzes the two successive C-2 and C-7 methylation reactions involved in the conversion of uroporphyrinogen III to precorrin-2 via the intermediate formation of precorrin-1.

    Polypeptides: Uroporphyrinogen-III C-methyltransferaseSynonyms: Urogen III methylase, Uroporphyrinogen III methylase
  7. Target

    uroporphyrinogen-III C-methyltransferase

    go.drugbank.com/bio_entities/BE0002529
    TargetThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

    Polypeptides: uroporphyrinogen-III C-methyltransferaseFunction: uroporphyrin-III C-methyltransferase activity
  8. Target

    Afimbrial adhesin AFA-III

    go.drugbank.com/bio_entities/BE0004225
    TargetEscherichia coli

    These adhesins bind to the Dr blood group antigen and also agglutinate human erythrocytes in the presence of D-mannose (mannose-resistant hemagglutination (MRHA)).

    Polypeptides: Afimbrial adhesin AFA-III
  9. Target

    Collagen alpha-1(III) chain

    go.drugbank.com/bio_entities/BE0002130
    TargetHumans

    Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. … Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12

    Polypeptides: Collagen alpha-1(III) chain
  10. Target

    DNA polymerase III subunit epsilon

    go.drugbank.com/bio_entities/BE0002492
    TargetEscherichia coli (strain K12)

    DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. … The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease (PubMed:6340117).

    Polypeptides: DNA polymerase III subunit epsilon