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Trimipramine Action Pathway
smpdb.ca/view/SMP0126348Drug actionBy binding to the sodium-dependent serotonin transporter and the sodium-dependent noradrenaline transporter, trimipramine fulfill its functions. … It is very similar to imipramine but it has more antihistaminic and sedative properties. Trimipramine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT) in the neurons.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreEnzymes: Aromatic-L-amino-acid decarboxylase, Sodium-dependent serotonin transporterImipramine Action Pathway (New)
smpdb.ca/view/SMP0126359Drug actionImipramine binds to the sodium-dependent serotonin transporter and to the sodium-dependent norepinephrine transporter reducing the reuptake of norepinephrine and serotonin by presynaptic neurons. … , and hallucinations.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreEnzymes: Aromatic-L-amino-acid decarboxylase, Sodium-dependent serotonin transporterNortriptyline Action Pathway
smpdb.ca/view/SMP0126345Drug actionIt is possible by its binding to the sodium-dependent noradrenaline transporter and to the sodium-dependent serotonin transporter. … This drug is also used off-label and it includes the treatment of chronic pain, myofascial pain, neuralgia, and irritable bowel syndrome.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreEnzymes: Aromatic-L-amino-acid decarboxylase, Sodium-dependent serotonin transporterDesipramine Action Pathway (New)
smpdb.ca/view/SMP0126352Drug actionIt binds to the sodium-dependent noradrenaline transporter and to the sodium-dependent serotonin transporter of the presynaptic neurons. … It can also be used to manage chronic neuropathic pain, as a second-line agent for the management of anxiety disorders, and as a second or third-line agent in ADHD management.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreEnzymes: Aromatic-L-amino-acid decarboxylase, Sodium-dependent serotonin transporterDoxepin Norepinephrine Reuptake Inhibitor Action Pathway (New)
smpdb.ca/view/SMP0126355Drug actionDoxepin binds to the sodium-dependent noradrenaline transporter and to the sodium-dependent serotonin transporter. … Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreEnzymes: Aromatic-L-amino-acid decarboxylase, Sodium-dependent serotonin transporterNorepinephrine Neurological
smpdb.ca/view/SMP0130946PhysiologicalNorepinephrine is synthesized from the amino acid tyrosine by a series of enzymatic steps in the adrenal medulla and postganglionic neurons of the sympathetic nervous system. … The principal end products are either Vanillylmandelic acid or a conjugated form of MHPG, both of which are thought to be biologically inactive and are excreted in the urine.[13]
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Dopamine · Levodopa +3 moreEnzymes: Aromatic-L-amino-acid decarboxylase, Sodium-dependent noradrenaline transporterClomipramine Action Pathway (New)
smpdb.ca/view/SMP0126354Drug actionIt blocks both sodium-dependent serotonin and sodium-dependent norepinephrine transporters from removing serotonin and norepinephrine respectively from the synaptic clefts in the brain. … , and Tourette’s disorder.
Enzymes: Aromatic-L-amino-acid decarboxylase, Sodium-dependent serotonin transporterDuloxetine (SNRI) - Norepinephrine Reuptake Inhibiton
smpdb.ca/view/SMP0125000Drug actionIt blocks both sodium dependent serotonin and sodium dependent norepinephrine transporters from removing serotonin and norepinephrine respectively from the synaptic cleft. … The receptors that are being stimulated are 5-HT 2A, 2B, and 2C serotonin receptors and alpha 1 and beta 1 adrenergic receptors.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Duloxetine · Dopamine +4 moreEnzymes: Aromatic-L-amino-acid decarboxylase, Sodium-dependent noradrenaline transporterAtomoxetine Action Pathway (New)
smpdb.ca/view/SMP0126353Drug actionAtomoxetine binds to the sodium-dependent noradrenaline transporter, this prevents the noradrenaline reuptake in the presynaptic neurons. … Due to atomoxetine's noradrenergic activity, it also has effects on the cardiovascular system such as increased blood pressure and tachycardia.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Atomoxetine · Sapropterin · Norepinephrine +5 moreEnzymes: Aromatic-L-amino-acid decarboxylase, Sodium-dependent noradrenaline transporterCocaine Norepinephrine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126544Drug actionCocaine inhibits the sodium-dependent noradrenaline channel which causes norepinephrine to accumulate in the synapse. … Cocaine is a local anesthesia and vasoconstrictor that is clinically used during diagnostic proceedures or during surgery in or through the nasal cavity.
Enzymes: Aromatic-L-amino-acid decarboxylase, Sodium-dependent noradrenaline transporter